3D Printing of Pharmaceuticals

3D Printing of Pharmaceuticals
Author: Abdul W. Basit,Simon Gaisford
Publsiher: Springer
Total Pages: 240
Release: 2018-08-06
Genre: Medical
ISBN: 9783319907550

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3D printing is forecast to revolutionise the pharmaceutical sector, changing the face of medicine development, manufacture and use. Potential applications range from pre-clinical drug development and dosage form design through to the fabrication of functionalised implants and regenerative medicine. Within clinical pharmacy practice, printing technologies may finally lead to the concept of personalised medicines becoming a reality. This volume aims to be the definitive resource for anyone thinking of developing or using 3D printing technologies in the pharmaceutical sector, with a strong focus on the translation of printing technologies to a clinical setting. This text brings together leading experts to provide extensive information on an array of 3D printing techniques, reviewing the current printing technologies in the pharmaceutical manufacturing supply chain, in particular, highlighting the state-of-the-art applications in medicine and discussing modern drug product manufacture from a regulatory perspective. This book is a highly valuable resource for a range of demographics, including academic researchers and the pharmaceutical industry, providing a comprehensive inventory detailing the current and future applications of 3D printing in pharmaceuticals. Abdul W. Basit is Professor of Pharmaceutics at the UCL School of Pharmacy, University College London. Abdul’s research sits at the interface between pharmaceutical science and gastroenterology, forging links between basic science and clinical outcomes. He leads a large and multidisciplinary research group, and the goal of his work is to further the understanding of gastrointestinal physiology by fundamental research. So far, this knowledge has been translated into the design of new technologies and improved disease treatments, many of which are currently in late-stage clinical trials. He has published over 350 papers, book chapters and abstracts and delivered more than 250 invited research presentations. Abdul is also a serial entrepreneur and has filed 25 patents and founded 3 pharmaceutical companies (Kuecept, Intract Pharma, FabRx). Abdul is a frequent speaker at international conferences, serves as a consultant to many pharmaceutical companies and is on the advisory boards of scientific journals, healthcare organisations and charitable bodies. He is the European Editor of the International Journal of Pharmaceutics. Abdul was the recipient of the Young Investigator Award in Pharmaceutics and Pharmaceutical Technology from the American Association of Pharmaceutical Scientists (AAPS) and is the only non-North American scientist to receive this award. He was also the recipient of the Academy of Pharmaceutical Sciences (APS) award. Simon Gaisford holds a Chair in Pharmaceutics and is Head of the Department of Pharmaceutics at the UCL School of Pharmacy, University College London. He has published 110 papers, 8 book chapters and 4 authored books. His research is focused on novel technologies for manufacturing medicines, particularly using ink-jet printing and 3D printing, and he is an expert in the physico-chemical characterisation of compounds and formulations with thermal methods and calorimetry.

3D Printing of Pharmaceuticals and Drug Delivery Devices

3D Printing of Pharmaceuticals and Drug Delivery Devices
Author: Dimitrios A. Lamprou
Publsiher: MDPI
Total Pages: 436
Release: 2020-07-01
Genre: Medical
ISBN: 9783039364237

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The 3D printing (3DP) process was patented in 1986; however, only in the last decade has it begun to be used for medical applications, as well as in the fields of prosthetics, bio-fabrication, and pharmaceutical printing. 3DP or additive manufacturing (AM) is a family of technologies that implement layer-by-layer processes in order to fabricate physical models based on a computer aided design (CAD) model. 3D printing permits the fabrication of high degrees of complexity with great reproducibility in a fast and cost-effective fashion. 3DP technology offers a new paradigm for the direct manufacture of individual dosage forms and has the potential to allow for variations in size and geometry as well as control dose and release behavior. Furthermore, the low cost and ease of use of 3DP systems means that the possibility of manufacturing medicines and medical devices at the point of dispensing or at the point of use could become a reality. 3DP thus offers the perfect innovative manufacturing route to address the critical capability gap that hinders the widespread exploitation of personalized medicines for molecules that are currently not easy to deliver. This Special Issue will address new developments in the area of 3D printing and bioprinting for drug delivery applications, covering the recent advantages and future directions of additive manufacturing for pharmaceutical products.

3D Printing in Medicine

3D Printing in Medicine
Author: Deepak M Kalaskar
Publsiher: Woodhead Publishing
Total Pages: 178
Release: 2017-04-17
Genre: Technology & Engineering
ISBN: 9780081007266

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3D Printing in Medicine examines the emerging market of 3D-printed biomaterials and its clinical applications. With a particular focus on both commercial and premarket tools, the book looks at their applications within medicine and the future outlook for the field. The book begins with a discussion of the fundamentals of 3D printing, including topics such as materials, and hardware. Chapters go on to cover applications within medicine such as computational analysis of 3D printed constructs, personalized 3D printing and 3D cell and organ printing. The concluding chapters in the book review the applications of 3D printing in diagnostics, drug development, 3D-printed disease models and 3D printers for surgical practice. With a strong focus on the translation of 3D printing technology to a clinical setting, this book is a valuable resource for scientists and engineers working in biomaterial, biomedical, and nanotechnology based industries and academia. Provides a comprehensive and authoritative overview of all the medical applications of 3D printing biomaterials and technologies Focuses on the emerging market of 3D printed biomaterials in clinical applications Reviews both commercial and under development materials, tools, their applications, and future evolution

Pharmaceutical Formulation Design

Pharmaceutical Formulation Design
Author: Usama Ahmad,Juber Akhtar
Publsiher: BoD – Books on Demand
Total Pages: 164
Release: 2020-02-05
Genre: Medical
ISBN: 9781789856620

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Pharmaceutical formulations have evolved from simple and traditional systems to more modern and complex novel dosage forms. Formulation development is a tedious process and requires an enormous amount of effort from many different people. Developing a stable novel dosage form and further targeting it to the desired site inside the body has always been a challenge. The purpose of this book is to bring together scholarly articles that highlight recent developments and trends in pharmaceutical formulation science. Each article has been written by authors specializing in the subject area and hailing from top institutions around the world. The book has been written in a systematic and lucid style explaining all basic concepts and fundamentals in a very simple way. This book aims to serve the need of all individuals involved at any level in the pharmaceutical dosage form development. I sincerely hope that the book will be liked by inquisitive students and learned colleagues.

3D Printing Technology in Nanomedicine

3D Printing Technology in Nanomedicine
Author: Nabeel Ahmad,P. Gopinath,Rajiv Dutta
Publsiher: Elsevier
Total Pages: 202
Release: 2019-03-30
Genre: Technology & Engineering
ISBN: 9780128158913

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3D Printing Technology in Nanomedicine provides an integrated and introductory look into the rapidly evolving field of nanobiotechnology. It demystifies the processes of commercialization and discusses legal and regulatory considerations. With a focus on nanoscale processes and biomedical applications, users will find this to be a comprehensive resource on how 3D printing can be utilized in a range of areas, including the diagnosis and treatment of a variety of human diseases. Examines the emerging market of 3D-printed biomaterials and their clinical applications, with a particular focus on both commercial and premarket tools Examines the promising market of 3D-printed nanoparticles, nanomaterial, biomaterials, composite nanomaterial and their clinical applications in the cardiovascular and chemotherapy realms Develops the concept of integrating different technologies along the hierarchical structure of biological systems

Advanced 3D Printed Systems and Nanosystems for Drug Delivery and Tissue Engineering

Advanced 3D Printed Systems and Nanosystems for Drug Delivery and Tissue Engineering
Author: Lisa Du Toit,Pradeep Kumar,Yahya Choonara,Viness Pillay
Publsiher: Elsevier
Total Pages: 316
Release: 2020-03-08
Genre: Technology & Engineering
ISBN: 9780128184721

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Advanced 3D-Printed Systems and Nanosystems for Drug Delivery and Tissue Engineering explores the intricacies of nanostructures and 3D printed systems in terms of their design as drug delivery or tissue engineering devices, their further evaluations and diverse applications. The book highlights the most recent advances in both nanosystems and 3D-printed systems for both drug delivery and tissue engineering applications. It discusses the convergence of biofabrication with nanotechnology, constructing a directional customizable biomaterial arrangement for promoting tissue regeneration, combined with the potential for controlled bioactive delivery. These discussions provide a new viewpoint for both biomaterials scientists and pharmaceutical scientists. Shows how nanotechnology and 3D printing are being used to create systems which are intelligent, biomimetic and customizable to the patient Explores the current generation of nanostructured 3D printed medical devices Assesses the major challenges of using 3D printed nanosystems for the manufacture of new pharmaceuticals

Micro and Nanomanufacturing Volume II

Micro and Nanomanufacturing Volume II
Author: Mark J. Jackson,Waqar Ahmed
Publsiher: Springer
Total Pages: 570
Release: 2017-10-28
Genre: Technology & Engineering
ISBN: 9783319671321

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This book is a comprehensive treatment of micro and nanofabrication techniques, and applies established and research laboratory manufacturing techniques to a wide variety of materials. It is a companion volume to “Micro and Nanomanufacturing” (2007) and covers new topics such as aligned nanowire growth, molecular dynamics simulation of nanomaterials, atomic force microscopy for microbial cell surfaces, 3D printing of pharmaceuticals, microvascular coaptation methods, and more. The chapters also cover a wide variety of applications in areas such as surgery, auto components, living cell detection, dentistry, nanoparticles in medicine, and aerospace components. This is an ideal text for professionals working in the field, and for graduate students in micro and nanomanufacturing courses.

Fundamentals of 3D Food Printing and Applications

Fundamentals of 3D Food Printing and Applications
Author: Fernanda C. Godoi,Bhesh R. Bhandari,Sangeeta Prakash,Min Zhang
Publsiher: Academic Press
Total Pages: 406
Release: 2018-11-02
Genre: Technology & Engineering
ISBN: 9780128145654

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Fundamentals of 3D Food Printing and Applications provides an update on this emerging technology that can not only create complex edible shapes, but also enable the alteration of food texture and nutritional content required by specific diets. This book discusses 3D food printing technologies and their working mechanisms within a broad spectrum of application areas, including, but not limited to, the development of soft foods and confectionary designs. It provides a unique and contemporary guide to help correlate supply materials (edible inks) and the technologies (e.g., extrusion and laser based) used during the construction of computer-aided 3D shapes. Users will find a great reference that will help food engineers and research leaders in food science understand the characteristics of 3D food printing technologies and edible inks. Details existing 3D food printing techniques, with an in-depth discussion on the mechanisms of formation of self-supporting layers Includes the effects of flow behaviour and viscoelastic properties of printing materials Presents strategies to enhance printability, such as the incorporation of hydrocolloids and lubricant enhancers 3D printing features of a range of food materials, including cereal based, insect enriched, fruits and vegetables, chocolate and dairy ingredients Business development for chocolate printing and the prospects of 3D food printing at home for domestic applications Prosumer-driven 3D food printing Safety and labelling of 3D printed food

3D Printing in Medicine and Surgery

3D Printing in Medicine and Surgery
Author: Daniel J. Thomas,Deepti Singh
Publsiher: Woodhead Publishing
Total Pages: 304
Release: 2020-08-14
Genre: Medical
ISBN: 9780081025437

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3D Printing in Medicine and Surgery: Applications in Healthcare is an advanced book on surgical and enhanced medical applications that can be achieved with 3D printing. It is an essential handbook for medical practitioners, giving access to a range of practical methods, while also focusing on applied knowledge. This comprehensive resource features practical experiments and processes for preparing 3D printable materials. Early chapters cover foundational knowledge and background reading, while later chapters discuss and review the current technologies used to engineer specific tissue types, experiments and methods, medical approaches and the challenges that lie ahead for future research. The book is an indispensable reference guide to the various methods used by current medical practitioners working at the forefront of 3D printing applications in medicine. Provides a detailed introduction and narrative on how 3-D printing can be used towards developing future medicine-based therapies Covers up-to-date methods across a range of application areas for the first time in book form Presents the only book on all current areas of 3D printing in medicine that is catered to a medical rather than engineering audience

3D Printing of Concrete

3D Printing of Concrete
Author: Arnaud Perrot
Publsiher: John Wiley & Sons
Total Pages: 135
Release: 2019-04-10
Genre: Technology & Engineering
ISBN: 9781119610786

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The introduction of digital manufacturing techniques, such as 3D printing applied to concrete material, opens up new perspectives on the way in which buildings are designed. Research on this theme is thriving and there is a high rate of innovation related to concrete. At the same time, the first life-size constructions made from printed concrete are emerging from the ground. This book presents state-of-the-art knowledge on the different printing processes as well as on the concrete material that must adapt to these new manufacturing techniques, such as new hardware and new printers for concrete. The possibilities in terms of architectural design are discussed as well as the pathways that remain to be uncovered. The book also explores the challenges that researchers and companies expect to overcome as they get closer to democratizing this potential revolution that is the digital manufacturing of concrete.

Application of Ionic Liquids in Drug Delivery

Application of Ionic Liquids in Drug Delivery
Author: Masahiro Goto,Muhammad Moniruzzaman
Publsiher: Springer Nature
Total Pages: 242
Release: 2021-08-27
Genre: Science
ISBN: 9789811643651

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This book presents recent advances in the use of ionic liquids in medicine and pharmaceutics with particular emphasis on addressing critical pharmaceutical challenges, including the low solubility, polymorphism, and bioavailability of drugs. It also provides insights into the development of the biologically functionalized ionic liquids suitable for medical and pharmaceutical applications. Ionic liquids have been used as potential solvents or materials in the fields of pharmaceutical drug delivery and formulations because of their unique and tunable physicochemical and biological properties. Readers find explanations of the diverse approaches to the application of ionic liquids in drug solubility, active pharmaceutical ingredient (API) formulation, and drug delivery systems, such as topical, transdermal, and oral delivery, with particular emphasis on recent developments. Particular attention is given to the development of ionic liquid-assisted effective drug delivery techniques for sparingly soluble or insoluble drug molecules. This book also discusses the biological activities of ionic liquids for possible applications in drug formulation and drug delivery systems. Scientists in disciplines such as chemistry, biology, and pharmaceutics find this book instructive and informative for developing ionic liquid-based drug formulations or drug delivery systems.

3D Printing for the Radiologist E Book

3D Printing for the Radiologist  E Book
Author: Nicole Wake
Publsiher: Elsevier Health Sciences
Total Pages: 242
Release: 2021-05-27
Genre: Medical
ISBN: 9780323775748

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Comprehensive, yet concise, 3D Printing for the Radiologist presents an overview of three-dimensional printing at the point of care. Focusing on opportunities and challenges in radiology practice, this up-to-date reference covers computer-aided design principles, quality assurance, training, and guidance for integrating 3D printing across radiology subspecialties. Practicing and trainee radiologists, surgeons, researchers, and imaging specialists will find this an indispensable resource for furthering their understanding of the current state and future outlooks for 3D printing in clinical medicine. Covers a wide range of topics, including basic principles of 3D printing, quality assurance, regulatory perspectives, and practical implementation in medical training and practice. Addresses the challenges associated with 3D printing integration in clinical settings, such as reimbursement, regulatory issues, and training. Features concise chapters from a team of multidisciplinary chapter authors, including practicing radiologists, researchers, and engineers. Consolidates today’s available information on this timely topic into a single, convenient, resource.

The Future of Pharmaceutical Product Development and Research

The Future of Pharmaceutical Product Development and Research
Author: Anonim
Publsiher: Academic Press
Total Pages: 976
Release: 2020-09-02
Genre: Medical
ISBN: 9780128144558

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The Future of Pharmaceutical Product Development and Research examines the latest developments in the pharmaceutical sciences, also highlighting key developments, research and future opportunities. Written by experts in the field, this volume in the Advances in Pharmaceutical Product Development and Research series deepens our understanding of the product development phase of drug discovery and drug development. Each chapter covers fundamental principles, advanced methodologies and technologies employed by pharmaceutical scientists, researchers and the pharmaceutical industry. The book focuses on excipients, radiopharmaceuticals, and how manufacturing should be conducted in an environment that follows Good Manufacturing Practice (GMP) guidelines. Researchers and students will find this book to be a comprehensive resource for those working in, and studying, pharmaceuticals, cosmetics, biotechnology, foods and related industries. Provides an overview of practical information for clinical trials Outlines how to ensure an environment that follows Good Manufacturing Practice (GMP) Examines recent developments and suggests future directions for drug production methods and techniques

3D Printing of Pharmaceuticals and Drug Delivery Devices

3D Printing of Pharmaceuticals and Drug Delivery Devices
Author: Dimitrios A. Lamprou
Publsiher: Unknown
Total Pages: 436
Release: 2020
Genre: Electronic Book
ISBN: 3039364243

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The 3D printing (3DP) process was patented in 1986; however, only in the last decade has it begun to be used for medical applications, as well as in the fields of prosthetics, bio-fabrication, and pharmaceutical printing. 3DP or additive manufacturing (AM) is a family of technologies that implement layer-by-layer processes in order to fabricate physical models based on a computer aided design (CAD) model. 3D printing permits the fabrication of high degrees of complexity with great reproducibility in a fast and cost-effective fashion. 3DP technology offers a new paradigm for the direct manufacture of individual dosage forms and has the potential to allow for variations in size and geometry as well as control dose and release behavior. Furthermore, the low cost and ease of use of 3DP systems means that the possibility of manufacturing medicines and medical devices at the point of dispensing or at the point of use could become a reality. 3DP thus offers the perfect innovative manufacturing route to address the critical capability gap that hinders the widespread exploitation of personalized medicines for molecules that are currently not easy to deliver. This Special Issue will address new developments in the area of 3D printing and bioprinting for drug delivery applications, covering the recent advantages and future directions of additive manufacturing for pharmaceutical products.

Fused Deposition Modeling Based 3D Printing

Fused Deposition Modeling Based 3D Printing
Author: Harshit K. Dave,J. Paulo Davim
Publsiher: Springer Nature
Total Pages: 515
Release: 2021-04-21
Genre: Technology & Engineering
ISBN: 9783030680244

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This book covers 3D printing activities by fused deposition modeling process. The two introductory chapters discuss the principle, types of machines and raw materials, process parameters, defects, design variations and simulation methods. Six chapters are devoted to experimental work related to process improvement, mechanical testing and characterization of the process, followed by three chapters on post-processing of 3D printed components and two chapters addressing sustainability concerns. Seven chapters discuss various applications including composites, external medical devices, drug delivery system, orthotic inserts, watertight components and 4D printing using FDM process. Finally, six chapters are dedicated to the study on modeling and optimization of FDM process using computational models, evolutionary algorithms, machine learning, metaheuristic approaches and optimization of layout and tool path.