A Comprehensive Physically Based Approach to Modeling in Bioengineering and Life Sciences

A Comprehensive Physically Based Approach to Modeling in Bioengineering and Life Sciences
Author: Riccardo Sacco,Giovanna Guidoboni,Aurelio Giancarlo Mauri
Publsiher: Academic Press
Total Pages: 854
Release: 2019-07-18
Genre: Technology & Engineering
ISBN: 9780128125199

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A Comprehensive Physically Based Approach to Modeling in Bioengineering and Life Sciences provides a systematic methodology to the formulation of problems in biomedical engineering and the life sciences through the adoption of mathematical models based on physical principles, such as the conservation of mass, electric charge, momentum, and energy. It then teaches how to translate the mathematical formulation into a numerical algorithm that is implementable on a computer. The book employs computational models as synthesized tools for the investigation, quantification, verification, and comparison of different conjectures or scenarios of the behavior of a given compartment of the human body under physiological and pathological conditions. Presents theoretical (modeling), biological (experimental), and computational (simulation) perspectives Features examples, exercises, and MATLAB codes for further reader involvement Covers basic and advanced functional and computational techniques throughout the book

Recent Developments in Mathematical Statistical and Computational Sciences

Recent Developments in Mathematical  Statistical and Computational Sciences
Author: D. Marc Kilgour,Herb Kunze,Roman Makarov,Roderick Melnik,Xu Wang
Publsiher: Springer Nature
Total Pages: 757
Release: 2021-09-30
Genre: Mathematics
ISBN: 9783030635916

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This book constitutes an up-to-date account of principles, methods, and tools for mathematical and statistical modelling in a wide range of research fields, including medicine, health sciences, biology, environmental science, engineering, physics, chemistry, computation, finance, economics, and social sciences. It presents original solutions to real-world problems, emphasizes the coordinated development of theories and applications, and promotes interdisciplinary collaboration among mathematicians, statisticians, and researchers in other disciplines. Based on a highly successful meeting, the International Conference on Applied Mathematics, Modeling and Computational Science, AMMCS 2019, held from August 18 to 23, 2019, on the main campus of Wilfrid Laurier University, Waterloo, Canada, the contributions are the results of submissions from the conference participants. They provide readers with a broader view of the methods, ideas and tools used in mathematical, statistical and computational sciences.

Computational Bioengineering and Bioinformatics

Computational Bioengineering and Bioinformatics
Author: Nenad Filipovic
Publsiher: Springer Nature
Total Pages: 169
Release: 2020-03-11
Genre: Technology & Engineering
ISBN: 9783030436582

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This book explores the latest and most relevant topics in the field of computational bioengineering and bioinformatics, with a particular focus on patient-specific, disease-progression modeling. It covers computational methods for cardiovascular disease prediction, with an emphasis on biomechanics, biomedical decision support systems, data mining, personalized diagnostics, bio-signal processing, protein structure prediction, biomedical image processing, analysis and visualization, and high-performance computing. It also discusses state-of-the-art tools for disease characterization, and recent advances in areas such as biomechanics, cardiovascular engineering, patient-specific modeling, population-based modeling, multiscale modeling, image processing, data mining, biomedical decision-support systems, signal processing, biomaterials and dental biomechanics, tissue and cell engineering, computational chemistry and high-performance computing. As such, it is a valuable resource for researchers, medical and bioengineering students, and medical device and software experts

Computational Modeling in Biomedical Engineering and Medical Physics

Computational Modeling in Biomedical Engineering and Medical Physics
Author: Alexandru Morega,Mihaela Morega,Alin Dobre
Publsiher: Academic Press
Total Pages: 314
Release: 2020-09-15
Genre: Science
ISBN: 9780128178980

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Mathematical and numerical modelling of engineering problems in medicine is aimed at unveiling and understanding multidisciplinary interactions and processes and providing insights useful to clinical care and technology advances for better medical equipment and systems. When modelling medical problems, the engineer is confronted with multidisciplinary problems of electromagnetism, heat and mass transfer, and structural mechanics with, possibly, different time and space scales, which may raise concerns in formulating consistent, solvable mathematical models. Computational Medical Engineering presents a number of engineering for medicine problems that may be encountered in medical physics, procedures, diagnosis and monitoring techniques, including electrical activity of the heart, hemodynamic activity monitoring, magnetic drug targeting, bioheat models and thermography, RF and microwave hyperthermia, ablation, EMF dosimetry, and bioimpedance methods. The authors discuss the core approach methodology to pose and solve different problems of medical engineering, including essentials of mathematical modelling (e.g., criteria for well-posed problems); physics scaling (homogenization techniques); Constructal Law criteria in morphing shape and structure of systems with internal flows; computational domain construction (CAD and, or reconstruction techniques based on medical images); numerical modelling issues, and validation techniques used to ascertain numerical simulation results. In addition, new ideas and venues to investigate and understand finer scale models and merge them into continuous media medical physics are provided as case studies. Presents the fundamentals of mathematical and numerical modeling of engineering problems in medicine Discusses many of the most common modelling scenarios for Biomedical Engineering, including, electrical activity of the heart hemodynamic activity monitoring, magnetic drug targeting, bioheat models and thermography, RF and microwave hyperthermia, ablation, EMF dosimetry, and bioimpedance methods Includes discussion of the core approach methodology to pose and solve different problems of medical engineering, including essentials of mathematical modelling, physics scaling, Constructal Law criteria in morphing shape and structure of systems with internal flows, computational domain construction, numerical modelling issues, and validation techniques used to ascertain numerical simulation results

Modeling and Simulation in Biomedical Engineering Applications in Cardiorespiratory Physiology

Modeling and Simulation in Biomedical Engineering  Applications in Cardiorespiratory Physiology
Author: Willem van Meurs
Publsiher: McGraw Hill Professional
Total Pages: 224
Release: 2011-08-07
Genre: Technology & Engineering
ISBN: 9780071714464

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THEORY AND PRACTICE OF MODELING AND SIMULATING HUMAN PHYSIOLOGY Written by a coinventor of the Human Patient Simulator (HPS) and past president of the Society in Europe for Simulation Applied to Medicine (SESAM), Modeling and Simulation in Biomedical Engineering: Applications in Cardiorespiratory Physiology is a compact and consistent introduction to this expanding field. The book divides the modeling and simulation process into five manageable steps--requirements, conceptual models, mathematical models, software implementation, and simulation results and validation. A framework and a basic set of deterministic, continuous-time models for the cardiorespiratory system are provided. This timely resource also addresses advanced topics, including sensitivity analysis and setting model requirements as part of an encompassing simulation and simulator design. Practical examples provide you with the skills to evaluate and adapt existing physiologic models or create new ones for specific applications. Coverage includes: Signals and systems Model requirements Conceptual models Mathematical models Software implementation Simulation results and model validation Cardiorespiratory system model Circulation Respiration Physiologic control Sensitivity analysis of a cardiovascular model Design of model-driven acute care training simulators “Uniquely qualified to author such a text, van Meurs is one of the original developers of CAE Healthcare’s Human Patient Simulator (HPS). ...His understanding of mathematics, human physiology, pharmacology, control systems, and systems engineering, combined with a conversational writing style, results in a readable text. ...The ample illustrations and tables also break up the text and make reading the book easier on the eyes. ...concise yet in conversational style, with real-life examples. This book is highly recommended for coursework in physiologic modeling and for all who are interested in simulator design and development. The book pulls all these topics together under one cover and is an important contribution to biomedical literature.” --IEEE Pulse, January 2014 “This book is written by a professional engineer who is unique in that he seems to have a natural understanding of 3 key areas as follows: the hardware involved with simulators, human physiology, and mathematical modeling. Willem van Meurs is one of the inventors of the model-driven human patient simulator (HPS), and so, he is very qualified to write this book. The book is written in a clear way, using the first person throughout, in a conversational manner, with a style that involves posing questions and answering them in subsequent text. ...The book starts with a very useful introduction and background chapter, setting out the scene for the rest of the book. ...I have used his book in enhancing my own talks and understanding human patient simulation and can strongly recommend it.” --Simulation in Healthcare December, 2012 Reviewed by Mark A. Tooley, Ph.D., Department of Medical Physics and Bioengineering, Royal United Hospital, Combe Park, Bath, UK.

Comprehensive Biomedical Physics

Comprehensive Biomedical Physics
Author: Anonim
Publsiher: Newnes
Total Pages: 4056
Release: 2014-07-25
Genre: Science
ISBN: 9780444536334

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Comprehensive Biomedical Physics is a new reference work that provides the first point of entry to the literature for all scientists interested in biomedical physics. It is of particularly use for graduate and postgraduate students in the areas of medical biophysics. This Work is indispensable to all serious readers in this interdisciplinary area where physics is applied in medicine and biology. Written by leading scientists who have evaluated and summarized the most important methods, principles, technologies and data within the field, Comprehensive Biomedical Physics is a vital addition to the reference libraries of those working within the areas of medical imaging, radiation sources, detectors, biology, safety and therapy, physiology, and pharmacology as well as in the treatment of different clinical conditions and bioinformatics. This Work will be valuable to students working in all aspect of medical biophysics, including medical imaging and biomedical radiation science and therapy, physiology, pharmacology and treatment of clinical conditions and bioinformatics. The most comprehensive work on biomedical physics ever published Covers one of the fastest growing areas in the physical sciences, including interdisciplinary areas ranging from advanced nuclear physics and quantum mechanics through mathematics to molecular biology and medicine Contains 1800 illustrations, all in full color

Encyclopedia of Bioinformatics and Computational Biology

Encyclopedia of Bioinformatics and Computational Biology
Author: Anonim
Publsiher: Elsevier
Total Pages: 3284
Release: 2018-08-21
Genre: Medical
ISBN: 9780128114322

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Encyclopedia of Bioinformatics and Computational Biology: ABC of Bioinformatics combines elements of computer science, information technology, mathematics, statistics and biotechnology, providing the methodology and in silico solutions to mine biological data and processes. The book covers Theory, Topics and Applications, with a special focus on Integrative –omics and Systems Biology. The theoretical, methodological underpinnings of BCB, including phylogeny are covered, as are more current areas of focus, such as translational bioinformatics, cheminformatics, and environmental informatics. Finally, Applications provide guidance for commonly asked questions. This major reference work spans basic and cutting-edge methodologies authored by leaders in the field, providing an invaluable resource for students, scientists, professionals in research institutes, and a broad swath of researchers in biotechnology and the biomedical and pharmaceutical industries. Brings together information from computer science, information technology, mathematics, statistics and biotechnology Written and reviewed by leading experts in the field, providing a unique and authoritative resource Focuses on the main theoretical and methodological concepts before expanding on specific topics and applications Includes interactive images, multimedia tools and crosslinking to further resources and databases

The Biomedical Engineering Handbook

The Biomedical Engineering Handbook
Author: Joseph D. Bronzino,Donald R. Peterson
Publsiher: CRC Press
Total Pages: 5430
Release: 2018-10-03
Genre: Medical
ISBN: 9781439863114

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The definitive "bible" for the field of biomedical engineering, this collection of volumes is a major reference for all practicing biomedical engineers and students. Now in its fourth edition, this work presents a substantial revision, with all sections updated to offer the latest research findings. New sections address drugs and devices, personali

Biomedical Image Segmentation

Biomedical Image Segmentation
Author: Ayman El-Baz,Xiaoyi Jiang,Jasjit S. Suri
Publsiher: CRC Press
Total Pages: 526
Release: 2016-11-17
Genre: Medical
ISBN: 9781482258561

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As one of the most important tasks in biomedical imaging, image segmentation provides the foundation for quantitative reasoning and diagnostic techniques. A large variety of different imaging techniques, each with its own physical principle and characteristics (e.g., noise modeling), often requires modality-specific algorithmic treatment. In recent years, substantial progress has been made to biomedical image segmentation. Biomedical image segmentation is characterized by several specific factors. This book presents an overview of the advanced segmentation algorithms and their applications.

Signal and Image Analysis for Biomedical and Life Sciences

Signal and Image Analysis for Biomedical and Life Sciences
Author: Changming Sun,Tomasz Bednarz,Tuan D. Pham,Pascal Vallotton,Dadong Wang
Publsiher: Springer
Total Pages: 276
Release: 2014-11-07
Genre: Computers
ISBN: 9783319109848

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With an emphasis on applications of computational models for solving modern challenging problems in biomedical and life sciences, this book aims to bring collections of articles from biologists, medical/biomedical and health science researchers together with computational scientists to focus on problems at the frontier of biomedical and life sciences. The goals of this book are to build interactions of scientists across several disciplines and to help industrial users apply advanced computational techniques for solving practical biomedical and life science problems. This book is for users in the fields of biomedical and life sciences who wish to keep abreast with the latest techniques in signal and image analysis. The book presents a detailed description to each of the applications. It can be used by those both at graduate and specialist levels.

Modelling Biomedical Signals

Modelling Biomedical Signals
Author: Giuseppe Nardulli,Sebastiano Stramaglia
Publsiher: World Scientific
Total Pages: 292
Release: 2002-05-24
Genre: Technology & Engineering
ISBN: 9789814489447

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In the last few years, concepts and methodologies initially developed in physics have found high applicability in many different areas. This book, a result of cross-disciplinary interaction among physicists, biologists and physicians, covers several topics where methods and approaches rooted in physics are successfully applied to analyze and to model biomedical data. Included are papers on physiological rhythms and synchronization phenomena, gene expression patterns, the immune system, decision support systems in medical science, protein folding and protein crystallography. The volume can be used as a valuable reference for graduate students and researchers at the interface of physics, biology and medicine.The proceedings have been selected for coverage in:• Index to Scientific & Technical Proceedings (ISTP CDROM version / ISI Proceedings)

Multiphysics Modeling Numerical Methods and Engineering Applications

Multiphysics Modeling  Numerical Methods and Engineering Applications
Author: Qun Zhang,Song Cen
Publsiher: Elsevier
Total Pages: 440
Release: 2015-12-15
Genre: Technology & Engineering
ISBN: 9780124077379

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Multiphysics Modeling: Numerical Methods and Engineering Applications: Tsinghua University Press Computational Mechanics Series describes the basic principles and methods for multiphysics modeling, covering related areas of physics such as structure mechanics, fluid dynamics, heat transfer, electromagnetic field, and noise. The book provides the latest information on basic numerical methods, also considering coupled problems spanning fluid-solid interaction, thermal-stress coupling, fluid-solid-thermal coupling, electromagnetic solid thermal fluid coupling, and structure-noise coupling. Users will find a comprehensive book that covers background theory, algorithms, key technologies, and applications for each coupling method. Presents a wealth of multiphysics modeling methods, issues, and worked examples in a single volume Provides a go-to resource for coupling and multiphysics problems Covers the multiphysics details not touched upon in broader numerical methods references, including load transfer between physics, element level strong coupling, and interface strong coupling, amongst others Discusses practical applications throughout and tackles real-life multiphysics problems across areas such as automotive, aerospace, and biomedical engineering

Life Cycle Decisions for Biomedical Data

Life Cycle Decisions for Biomedical Data
Author: National Academies of Sciences, Engineering, and Medicine,Policy and Global Affairs,Division on Earth and Life Studies,Division on Engineering and Physical Sciences,Board on Research Data and Information,Board on Life Sciences,Computer Science and Telecommunications Board,Committee on Applied and Theoretical Statistics,Board on Mathematical Sciences and Analytics,Committee on Forecasting Costs for Preserving and Promoting Access to Biomedical Data
Publsiher: National Academies Press
Total Pages: 184
Release: 2020-10-04
Genre: Science
ISBN: 9780309670036

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Biomedical research results in the collection and storage of increasingly large and complex data sets. Preserving those data so that they are discoverable, accessible, and interpretable accelerates scientific discovery and improves health outcomes, but requires that researchers, data curators, and data archivists consider the long-term disposition of data and the costs of preserving, archiving, and promoting access to them. Life Cycle Decisions for Biomedical Data examines and assesses approaches and considerations for forecasting costs for preserving, archiving, and promoting access to biomedical research data. This report provides a comprehensive conceptual framework for cost-effective decision making that encourages data accessibility and reuse for researchers, data managers, data archivists, data scientists, and institutions that support platforms that enable biomedical research data preservation, discoverability, and use.

Complex Systems Science in Biomedicine

Complex Systems Science in Biomedicine
Author: Thomas Deisboeck,J. Yasha Kresh
Publsiher: Springer Science & Business Media
Total Pages: 864
Release: 2007-06-13
Genre: Medical
ISBN: 9780387335322

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Complex Systems Science in Biomedicine Thomas S. Deisboeck and J. Yasha Kresh Complex Systems Science in Biomedicine covers the emerging field of systems science involving the application of physics, mathematics, engineering and computational methods and techniques to the study of biomedicine including nonlinear dynamics at the molecular, cellular, multi-cellular tissue, and organismic level. With all chapters helmed by leading scientists in the field, Complex Systems Science in Biomedicine's goal is to offer its audience a timely compendium of the ongoing research directed to the understanding of biological processes as whole systems instead of as isolated component parts. In Parts I & II, Complex Systems Science in Biomedicine provides a general systems thinking perspective and presents some of the fundamental theoretical underpinnings of this rapidly emerging field. Part III then follows with a multi-scaled approach, spanning from the molecular to macroscopic level, exemplified by studying such diverse areas as molecular networks and developmental processes, the immune and nervous systems, the heart, cancer and multi-organ failure. The volume concludes with Part IV that addresses methods and techniques driven in design and development by this new understanding of biomedical science. Key Topics Include: • Historic Perspectives of General Systems Thinking • Fundamental Methods and Techniques for Studying Complex Dynamical Systems • Applications from Molecular Networks to Disease Processes • Enabling Technologies for Exploration of Systems in the Life Sciences Complex Systems Science in Biomedicine is essential reading for experimental, theoretical, and interdisciplinary scientists working in the biomedical research field interested in a comprehensive overview of this rapidly emerging field. About the Editors: Thomas S. Deisboeck is currently Assistant Professor of Radiology at Massachusetts General Hospital and Harvard Medical School in Boston. An expert in interdisciplinary cancer modeling, Dr. Deisboeck is Director of the Complex Biosystems Modeling Laboratory which is part of the Harvard-MIT Martinos Center for Biomedical Imaging. J. Yasha Kresh is currently Professor of Cardiothoracic Surgery and Research Director, Professor of Medicine and Director of Cardiovascular Biophysics at the Drexel University College of Medicine. An expert in dynamical systems, he holds appointments in the School of Biomedical Engineering and Health Systems, Dept. of Mechanical Engineering and Molecular Pathobiology Program. Prof. Kresh is Fellow of the American College of Cardiology, American Heart Association, Biomedical Engineering Society, American Institute for Medical and Biological Engineering.

A Biologist s Guide to Mathematical Modeling in Ecology and Evolution

A Biologist s Guide to Mathematical Modeling in Ecology and Evolution
Author: Sarah P. Otto,Troy Day
Publsiher: Princeton University Press
Total Pages: 744
Release: 2011-09-19
Genre: Science
ISBN: 9781400840915

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Thirty years ago, biologists could get by with a rudimentary grasp of mathematics and modeling. Not so today. In seeking to answer fundamental questions about how biological systems function and change over time, the modern biologist is as likely to rely on sophisticated mathematical and computer-based models as traditional fieldwork. In this book, Sarah Otto and Troy Day provide biology students with the tools necessary to both interpret models and to build their own. The book starts at an elementary level of mathematical modeling, assuming that the reader has had high school mathematics and first-year calculus. Otto and Day then gradually build in depth and complexity, from classic models in ecology and evolution to more intricate class-structured and probabilistic models. The authors provide primers with instructive exercises to introduce readers to the more advanced subjects of linear algebra and probability theory. Through examples, they describe how models have been used to understand such topics as the spread of HIV, chaos, the age structure of a country, speciation, and extinction. Ecologists and evolutionary biologists today need enough mathematical training to be able to assess the power and limits of biological models and to develop theories and models themselves. This innovative book will be an indispensable guide to the world of mathematical models for the next generation of biologists. A how-to guide for developing new mathematical models in biology Provides step-by-step recipes for constructing and analyzing models Interesting biological applications Explores classical models in ecology and evolution Questions at the end of every chapter Primers cover important mathematical topics Exercises with answers Appendixes summarize useful rules Labs and advanced material available