Anti Angiogenesis Strategies in Cancer Therapies

Anti Angiogenesis Strategies in Cancer Therapies
Author: Shaker Mousa,Paul Davis
Publsiher: Academic Press
Total Pages: 210
Release: 2016-11-28
Genre: Medical
ISBN: 9780128026731

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Anti-angiogenesis Strategies in Cancer Therapeutics provides a detailed look at the current status and future directions in the discovery and development of novel anti-angiogenesis strategies in oncology. This book highlights the different mechanisms involved in the modulation of angiogenesis, including inflammation, thrombosis, and microRNA, and shows how nanotechnology can further enhance the potential of existing and new anti-angiogenesis approaches. Written for industry scientists, researchers, oncologists, hematologists, and professors and students in the field, this comprehensive book covers all aspects of anti-angiogenesis strategies and their differences. Covers important preclinical models and clinical trials in the discovery and development of novel anti-angiogenesis agents Reviews FDA-approved anti-angiogenesis agents Illustrates the value of nanotechnology in improving the utility of anti-angiogenesis agents Offers insight into the development of novel anti-angiogenesis agents and future direction in this area

Anti Angiogenesis Strategies in Cancer Therapies

Anti Angiogenesis Strategies in Cancer Therapies
Author: Shaker Mousa,Paul Davis
Publsiher: Academic Press
Total Pages: 210
Release: 2016-11-28
Genre: Medical
ISBN: 9780128026731

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Anti-angiogenesis Strategies in Cancer Therapeutics provides a detailed look at the current status and future directions in the discovery and development of novel anti-angiogenesis strategies in oncology. This book highlights the different mechanisms involved in the modulation of angiogenesis, including inflammation, thrombosis, and microRNA, and shows how nanotechnology can further enhance the potential of existing and new anti-angiogenesis approaches. Written for industry scientists, researchers, oncologists, hematologists, and professors and students in the field, this comprehensive book covers all aspects of anti-angiogenesis strategies and their differences. Covers important preclinical models and clinical trials in the discovery and development of novel anti-angiogenesis agents Reviews FDA-approved anti-angiogenesis agents Illustrates the value of nanotechnology in improving the utility of anti-angiogenesis agents Offers insight into the development of novel anti-angiogenesis agents and future direction in this area

Anti Angiogenesis Drug Discovery and Development

Anti Angiogenesis Drug Discovery and Development
Author: Atta-ur-Rahman,Muhammad Iqbal Choudhary
Publsiher: Elsevier
Total Pages: 326
Release: 2015-06-16
Genre: Science
ISBN: 9780128039649

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The inhibition of angiogenesis is an effective mechanism of slowing down tumor growth and malignancies. The process of induction or pro-angiogenesis is highly desirable for the treatment of cardiovascular diseases, wound healing disorders, and more. Efforts to understand the molecular basis, both for inhibition and induction, have yielded fascinating results. Originally published by Bentham and now distributed by Elsevier, Anti-Angiogenesis Drug Discovery and Development, Volume 2 is an compilation of well-written reviews on various aspects of the anti-angiogenesis process. These reviews have been contributed by leading practitioners in drug discovery science and highlight the major developments in this exciting field in the last two decades. These reader-friendly chapters cover topics of great scientific importance, many of which are considered significant medical breakthroughs, making this book excellent reading both for the novice as well as for expert medicinal chemists and clinicians. Edited and written by leading experts in angiogenesis drug development Reviews recent advances in the field, such as coverage of anti-angiogenetic drugs in ovarian cancer Reports current strategies and future outlook for anti-angiogenic therapy and cardiovascular diseases

Physiologic and Pathologic Angiogenesis

Physiologic and Pathologic Angiogenesis
Author: Dan Simionescu,Agneta Simionescu
Publsiher: BoD – Books on Demand
Total Pages: 464
Release: 2017-04-05
Genre: Medical
ISBN: 9789535130239

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The purpose of this book is to highlight novel advances in the field and to incentivize scientists from a variety of fields to pursue angiogenesis as a research avenue. Blood vessel formation and maturation to capillaries, arteries, or veins is a fascinating area which can appeal to multiple scientists, students, and professors alike. Angiogenesis is relevant to medicine, engineering, pharmacology, and pathology and to the many patients suffering from blood vessel diseases and cancer, among others. We are hoping that this book will become a source of inspiration and novel ideas for all.

Antiangiogenic Cancer Therapy

Antiangiogenic Cancer Therapy
Author: Darren W. Davis,Roy S. Herbst,James L. Abbruzzese
Publsiher: CRC Press
Total Pages: 864
Release: 2007-07-25
Genre: Science
ISBN: 1420004298

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Top Investigators Explore the Complexities of Angiogenesis Cancer Research The targeting of tumor angiogenesis has evolved into one of the most widely pursued therapeutic strategies. However, as of yet, no antiangiogenic agent used as a monotherapy has demonstrated a survival benefit in a randomized Phase III trial. The combination of bevacizumab, the first FDA approved angiogenesis inhibitor, with cytotoxic regimens has led to survival benefits in cancer patients. This has raised important questions about the complexities inherent in the clinical application of angiogenesis inhibitors. Compiles the results of four decades of progress Integrating fundamental concepts with therapeutic strategies, Anti-Angiogenic Cancer Therapy promotes the idea that an understanding of the molecular and cellular regulation of angiogenesis leads to optimal therapeutic strategies and positive clinical results. It brings together contributions from leading researchers to provide the most authoritative and encyclopedic volume available on this subject. Examines the role of angiogenesis in cancer, including strategies to prolong the nonangiogenic dormant state of human tumors, molecular mechanisms and cellular regulation of angiogenesis in solid tumors and hematologic malignancies, and the regulation of angiogenesis by the tumor microenvironment. Covers specific molecular targets for inhibiting angiogenesis in cancer therapy. Discusses clinical trial design and translational research approaches essential for identifying and developing effective angiogenesis inhibitors. Outlines current understanding of the molecular biology of each cancer type followed by discussions that examine strategies for targeting angiogenesis in specific cancers. This volume celebrates progress made in four decades, and more importantly, it provides a clear indication of the complex biology that needs further investigation to realize the possibilities envisioned for this beneficial therapeutic modality.

Anti Angiogenesis Strategies in Cancer Therapeutics

Anti Angiogenesis Strategies in Cancer Therapeutics
Author: Shaker Mousa,Paul Davis
Publsiher: Academic Press
Total Pages: 304
Release: 2016-12-16
Genre: Electronic Book
ISBN: 012802576X

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"Anti-angiogenesis Strategies in Cancer Therapeutics" provides a detailed look at the current status and future directions in the discovery and development of novel anti-angiogenesis strategies in oncology. This book highlights the different mechanisms involved in the modulation of angiogenesis, including inflammation, thrombosis, and microRNA, and shows how nanotechnology can further enhance the potential of existing and new anti-angiogenesis approaches. Written for industry scientists, researchers, oncologists, hematologists, and professors and students in the field, this comprehensive book covers all aspects of anti-angiogenesis strategies and their differences. Covers important preclinical models and clinical trials in the discovery and development of novel anti-angiogenesis agentsReviews FDA-approved anti-angiogenesis agentsIllustrates the value of nanotechnology in improving the utility of anti-angiogenesis agentsOffers insight into the development of novel anti-angiogenesis agents and future direction in this area

Angiogenesis Modulations in Health and Disease

Angiogenesis Modulations in Health and Disease
Author: Shaker A. Mousa,Paul J. Davis
Publsiher: Springer Science & Business Media
Total Pages: 206
Release: 2014-07-08
Genre: Medical
ISBN: 9789400764675

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This book is a major update of novel targets in angiogenesis modulation, including pro- and anti-angiogenesis. There is in-depth coverage of preclinical and clinical methods and models, investigational status, and clinical applications. The impact of nanotechnology in advancing the applications of pro-and anti-angiogenesis strategies is also highlighted, along with stem cell and biotechnologies in research and development of angiogenesis modulating targets.

Metronomic Chemotherapy

Metronomic Chemotherapy
Author: Guido Bocci,Giulio Francia
Publsiher: Springer
Total Pages: 295
Release: 2014-09-04
Genre: Medical
ISBN: 9783662436042

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This book analyzes all aspects of metronomic chemotherapy, a new approach involving low-dose, long-term, and frequently administered therapy that has preclinical and clinical activity in various tumors. After an opening section on the pharmacological bases of metronomic chemotherapy, including its antiangiogenic effects and impact on immunity, preclinical studies on various classes of drug are discussed. Clinical applications of metronomic chemotherapy in a wide variety of tumors are then addressed in detail, with description of the results of all published studies. The clinical pharmacology of metronomic chemotherapy is also considered in depth, encompassing pharmacokinetics, pharmacogenetics, pharmacoeconomics, and adverse drug reactions. The book closes by describing the role of this therapy in the veterinarian clinic.

Mechanisms of Angiogenesis

Mechanisms of Angiogenesis
Author: Matthias Clauss,Georg Breier
Publsiher: Springer Science & Business Media
Total Pages: 342
Release: 2004-11-22
Genre: Medical
ISBN: 3764364599

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Is it advisable to go back from bedside to the bench? During the last decade, few topics encountered such a broad interest in bio- gy and medicine as angiogenesis. The amazing ability of the body to restore blood flow by induction of blood vessel growth as part of an adaptive process has alarmed physicians dealing with diseases in which angiogenesis is either exaggerated (as in tumors) or too slow (as in ischemic diseases of heart and brain). Not surprisingly, pro- and antiangiogenic strategies have found their way into clinical trials. For instance, for the USA, the NIH website in early 2004 displayed 38 clinical studies involving either pro- or antiangiogenic th- apies. Given the expected overwhelming wealth of clinical data, the question may be asked whether further exploration of biological mechanisms is required or whether results from the bedside are instructive enough to proceed. This question depends also on the progress of pro- and antiangiogenic clinical trials. In the following, I give a short overview about some of the progress that has been made in this field. Since Judah Folkman proposed antiangiogenic tumor therapy thirty years ago, it has become increasingly evident that agents which interfere with blood vessel formation also block tumor progression. Accordingly, antiangiogenic therapy has gained much attention as a potential adjunct to conventional c- cer therapy.

Tumour Angiogenesis

Tumour Angiogenesis
Author: R. John Bicknell,Claire E. Lewis,Napoleone Ferrara
Publsiher: Oxford University Press, USA
Total Pages: 416
Release: 1997
Genre: Medical
ISBN: UOM:39015041324271

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It is now widely recognised that the growth of solid tumours is angiogenesis dependent. The inhibition of tumour angiogenesis offers a novel anti-cancer therapeutic strategy. In this first book to be devoted solely to tumour angiogenesis each chapter is written by leading world experts and the twenty seven chapters taken together cover all aspects of the field.

Angiogenesis Inhibitors and Stimulators

Angiogenesis Inhibitors and Stimulators
Author: Shaker A. Mousa
Publsiher: CRC Press
Total Pages: 162
Release: 2000-10
Genre: Medical
ISBN: UOM:39015051595091

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The regulation of blood vessel growth underlies many normal biological processes such as reproduction, development, repair and wound healing. It also is a critical feature of pathological processes such as cancer, diabetic retinopathy, macular degeneration, inflammatory arthritis and ischemic heart disease. What causes blood vessels to grow? What inhibits their growth? This book comprehensively describes the angiogenic proteins that enhance and inhibit normal and abnormal angiogenesis. It describes the potential therapeutic applications of basic fibroblast growth factor, vascular endothelial growth factor, PECAM-1 and thrombospondin as well as other factors. The book brings together information about new blood vessel formation in many organ systems and comprises an outstanding resource on the state-of-the art in angiogenesis.

Renal Disease in Cancer Patients

Renal Disease in Cancer Patients
Author: Kevin W. Finkel,Scott C. Howard
Publsiher: Academic Press
Total Pages: 312
Release: 2013-09-02
Genre: Medical
ISBN: 9780123982537

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Renal Disease in Cancer Patients is a translational reference detailing the nephrological problems unique to patients with cancer in an organized and authoritative fashion. This book provides a common language for nephrologists, oncologists, hematologists, and other clinicians who treat cancer patients, to discuss the development of renal diseases in the context of cancer and options for their optimum diagnosis, management, and treatment. With the advent of better supportive care and the era of personalized medicine, patients with cancer are living longer, and oncologists and nephrologists now recognize the serious consequences of renal disease among these patients. Designed especially with this new need in mind, Renal Disease in Cancer Patients presents the various renal diseases affecting cancer patients in a single, authoritative volume. The book covers topics in radiation nephritis, obstructive nephropathy, drug nephropathy, graft-versus-host disease, and more. Covers clinical description, diagnostics, management, and treatment throughout along with genetics, animal models, and pathology in specific chapters Summarizes all renal diseases unique to cancer patients in a single reference Provides a resource for oncologists and nephrologists, as well as general internal and family medicine practitioners, and physicians in training

Targets in Gene Therapy

Targets in Gene Therapy
Author: Yongping You
Publsiher: BoD – Books on Demand
Total Pages: 448
Release: 2011-08-23
Genre: Medical
ISBN: 9789533075402

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This book aims at providing an up-to-date report to cover key aspects of existing problems in the emerging field of targets in gene therapy. With the contributions in various disciplines of gene therapy, the book brings together major approaches: Target Strategy in Gene Therapy, Gene Therapy of Cancer and Gene Therapy of Other Diseases. This source enables clinicians and researchers to select and effectively utilize new translational approaches in gene therapy and analyze the developments in target strategy in gene therapy.

Inflammation and Angiogenesis

Inflammation and Angiogenesis
Author: Domenico Ribatti
Publsiher: Springer
Total Pages: 111
Release: 2018-09-09
Genre: Medical
ISBN: 3319886045

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This book is focused on the analysis of the role played by immune cell components in the angiogenic process associated with inflammation and tumor growth. Both innate and adaptive immune cells are involved in the mechanisms of endothelial cell proliferation, migration and activation, through the production and release of a large spectrum of pro-angiogenic mediators. These may create the specific microenvironment that favors an increased rate of tissue vascularization. The link between chronic inflammation and tumorigenesis was first proposed by Rudolf Virchow in 1863 after the observation that infiltrating leukocytes are a hallmark of tumors and first established a causative connection between the lymph reticular infiltrate at sites of chronic inflammation and the development of cancer. Tumors were described as wounds that never heal and surgeons have long described the tendency of tumors to recur in healing resection margin and it has been reported that wound healing environment provides an opportunistic matrix for tumor growth. As angiogenesis is the result of a net balance between the activities exerted by positive and negative regulators, this book will also provide information on some anti-angiogenic properties of immune cells that may be utilized for a potential pharmacological use as anti-angiogenic agents in inflammation as well as in cancer. The work is written for researchers in the field and also for graduate students which approach this matter.

Local Therapies for Glioma

Local Therapies for Glioma
Author: M. Westphal,J.-C. Tonn,Z. Ram
Publsiher: Springer Science & Business Media
Total Pages: 204
Release: 2003-08-29
Genre: Medical
ISBN: 3211403558

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In addition to surgery and radiotherapy, local treatment modalities for the management of brain tumours are increasingly being developed and clinically tested. This book describes for the first time basic tumour biology as well as all current procedures in progress at the most recent level of knowledge, presented by leading experts in the respective fields. Image guided resection procedures, fluorescence guided surgery, developments in interstitial radiosurgery are addressed, just as intracavitary chemotherapy and all current concepts and studies of interstitial targeted therapy. Owing to its topicality this book will remain for long the standard for this comprehensively treated subject.