Bone Cancer

Bone Cancer
Author: Dominique Heymann
Publsiher: Academic Press
Total Pages: 504
Release: 2009-08-20
Genre: Medical
ISBN: 0080953883

Download Bone Cancer Book in PDF, Epub and Kindle

The epidemiological and clinical importance of bone metastasis has long been recognized, but the past decade has seen an explosion in the fields of bone biology and bone cancer research. This period of time has been marked by a number of key discoveries that have led to the opening up of entirely new areas for investigation as well as new therapies which combine surgery and biological therapeutic approaches. Bone is a common site of cancer metastases - cancer cells commonly develop in bone and spread to other organ systems through the bloodstream. For example, the incidence of bone metastases in breast and prostate cancers is 70%, whereas it is only 30 to 40% in metastatic lung cancer. In clinical terms, bone metastases have substantial negative effects on a patient's quality of life and are a main cause of patient mortality. Given the global prevalence of breast and prostate cancers, knowledge of bone biology has become essential for the medical and cancer research communities. This book provides, all in one resource, the most recent data on bone cancer development (cellular and molecular mechanisms), genomic and proteomic analyses, clinical analyses (histopathology, imaging, pain monitoring), as well as new therapeutic approaches and clinical trials for primary bone tumors and bone metastases. Feature Presents a comprehensive, translational source for all aspects of bone cancer in one reference work Bone cancer experts (from all areas of research and practice) take readers from the bench research (cellular and molecular mechanism), through genomic and proteomic analysis, all the way to clinical analysis (histopathology and imaging) and new therapeutic approaches. Clear presentation by bone biologists of the cellular and molecular mechanisms underlying bone tumors and bone cancer metastasis as well as the genomic and proteomic assays used in detecting cancer within given organ systems Clear presentation by oncologists and radiologists of how histopathology, imaging, and pain monitoring can lead to new therapeutic approaches Benefit Saves researchers and clinicians time in quickly accessing the very latest details on a broad range of bone cancer issues, as opposed to searching through thousands of journal articles. Provides a common language for cancer researchers, bone biologists, oncologists, and radiologists to discuss bone tumors and how bone cancer metastases affects each major organ system Correct diagnosis (and therefore correct treatment) of cancer depends on a strong understanding of the molecular basis for the disease – both oncologists and radiologists will benefit Bone biologists will gain insight into how clinical observations and practices can feed back into the research cycle and will, therefore, be able to develop more targeted genomic and proteomic assays

Bone Cancer

Bone Cancer
Author: Dominique Heymann
Publsiher: Academic Press
Total Pages: 1078
Release: 2021-09-23
Genre: Medical
ISBN: 9780323899901

Download Bone Cancer Book in PDF, Epub and Kindle

Bone Cancer: Bone Sarcomas and Bone Metastases - From Bench to Bedside, Third Edition comprehensively investigates key discoveries in the field of bone biology. New aspects of bone cancer biology are treated in new chapters covering exosomes, autophagy, and metabolism. These have led to the development of entirely new areas for investigation, such as therapies which combine surgery and biological approaches. The Third Edition expands on the original overview of bone cancer development (physiology and pathophysiology), with 40% new material. Each chapter has been written by internationally recognized specialists on the bone cancer microenvironment, bone metastases, osteoclast biology in bone cancer, proteomics, bone niche, circulating tumor cells, and clinical trials. Given the global prevalence of breast and prostate cancers, knowledge of bone biology has become essential for everyone within the medical and cancer research communities. Bone Cancer: Bone Sarcomas and Bone Metastases - From Bench to Bedside continues to offer the only translational reference to cover all aspects of primary bone cancer and bone metastases. This revision opens the door to myeloma with two short chapters dedicated to this bone-associated disease. Covers the broad field of bone sarcomas and bone metastases from basic research to clinical approaches Presents comprehensive and translational overview of biological and clinical aspects of bone cancers, discussing pathophysiology from genetic and molecular levels using the most recent evidence Provides a common language for cancer researchers, bone biologists, oncologists, and radiologists to discuss bone tumors and how bone cancer metastases affects each major organ system Offers insights to research clinicians (oncologists and radiologists) into understanding the molecular basis of bone cancer, leading to more well-informed diagnoses and treatment of tumors and metastases Offers insights to bone biologists into how clinical observations and practices can feed back into the research cycle and, therefore, can contribute to the development of more targeted genomic and proteomic assays

Bone Cancer

Bone Cancer
Author: Dominique Heymann
Publsiher: Elsevier
Total Pages: 736
Release: 2014-09-04
Genre: Medical
ISBN: 9780124167285

Download Bone Cancer Book in PDF, Epub and Kindle

Bone Cancer, Second Edition comprehensively investigates key discoveries in the field of bone biology over the last five years that have led to the development of entirely new areas for investigation, such as therapies which combine surgery and biological approaches. The Second Edition expands on the original overview of bone cancer development (physiology and pathophysiology), with key chapters from the first edition, and offers numerous new chapters describing the new concepts of bone cancer biology and therapy, for both primary bone tumors as well as bone metastases. Each chapter has been written by internationally recognized specialists on the bone cancer microenvironment, bone metastases, osteoclast biology in bone cancer, proteomics, bone niche, circulating tumor cells, and clinical trials. Given the global prevalence of breast and prostate cancers, knowledge of bone biology has become essential for everyone within the medical and cancer research communities. Bone Cancer continues to offer the only translational reference to cover all aspects of primary bone cancer and bone metastases – from bench to bedside: development (cellular and molecular mechanisms), genomic and proteomic analyses, clinical analyses (histopathology, imaging, pain monitoring), as well as new therapeutic approaches and clinical trials for primary bone tumors and bone metastases. Presents a comprehensive, translational source for all aspects of primary bone cancer and bone metastases in one reference work Provides a common language for cancer researchers, bone biologists, oncologists, and radiologists to discuss bone tumors and how bone cancer metastases affects each major organ system Offers insights to research clinicians (oncologists and radiologists) into understanding the molecular basis of bone cancer, leading to more well-informed diagnoses and treatment of tumors and metastases Offers insights to bone biologists into how clinical observations and practices can feed back into the research cycle and, therefore, can contribute to the development of more targeted genomic and proteomic assays

AJCC Cancer Staging Manual

AJCC Cancer Staging Manual
Author: Frederick L, Greene,David L. Page,Irvin D. Fleming,April G. Fritz,Charles M. Balch,Daniel G. Haller,Monica Morrow
Publsiher: Springer Science & Business Media
Total Pages: 421
Release: 2013-11-21
Genre: Medical
ISBN: 9781475736564

Download AJCC Cancer Staging Manual Book in PDF, Epub and Kindle

The American Joint Committee on Cancer's Cancer Staging Manual is used by physicians throughout the world to diagnose cancer and determine the extent to which cancer has progressed. All of the TNM staging information included in this Sixth Edition is uniform between the AJCC (American Joint Committee on Cancer) and the UICC (International Union Against Cancer). In addition to the information found in the Handbook, the Manual provides standardized data forms for each anatomic site, which can be utilized as permanent patient records, enabling clinicians and cancer research scientists to maintain consistency in evaluating the efficacy of diagnosis and treatment. The CD-ROM packaged with each Manual contains printable copies of each of the book’s 45 Staging Forms.

Soft Tissue and Bone Tumours

Soft Tissue and Bone Tumours
Author: W. H. O. Classification WHO Classification of Tumours Editorial Board,Who Classification of Tumours Editorial
Publsiher: Unknown
Total Pages: 368
Release: 2020-04-17
Genre: Medical
ISBN: 9283245024

Download Soft Tissue and Bone Tumours Book in PDF, Epub and Kindle

PLEASE NOTE: Text has been accidentally deleted frompage 54 of this book. Please refer to the corrigenda (PDF file) posted on the Stylus Publishing web site or email [email protected] for an updated, printable page. ****When not purchasing directly from the official sales agents of the WHO, especially at online bookshops, please note that there have been issues with counterfeited copies. Buy only from known sellers and if there are quality issues, please contact the seller for a refund.***** Soft Tissue and Bone Tumoursis the third volume in the 5th edition ofthe WHO series on the classification of human tumours. This series (also knownas the WHO Blue Books) is regarded as the gold standard for the diagnosis oftumours and comprises a unique synthesis of histopathological diagnosis with digital and molecular pathology. These authoritative and concise referencebooks provide indispensable international standards for anyone involved in thecare of patients with cancer or in cancer research, underpinning individualpatient treatment as well as research into all aspects of cancer causation,prevention, therapy, and education. This volume will be of particular interest to pathologists, oncologists,surgeons, and epidemiologists who manage or research soft tissue and bonetumours. Sections are included on all recognized neoplasms of the soft tissueand bone, as well as on genetic tumour syndromes affecting these sites. Sincethe previous edition, there have been changes based on recent molecular andgenetic information, with impact on clinical practice.

Holland Frei Cancer Medicine

Holland Frei Cancer Medicine
Author: Robert C. Bast, Jr.,Carlo M. Croce,William N. Hait,Waun Ki Hong,Donald W. Kufe,Martine Piccart-Gebhart,Raphael E. Pollock,Ralph R. Weichselbaum,Hongyang Wang,James F. Holland
Publsiher: John Wiley & Sons
Total Pages: 2008
Release: 2017-03-10
Genre: Medical
ISBN: 9781119000846

Download Holland Frei Cancer Medicine Book in PDF, Epub and Kindle

Holland-Frei Cancer Medicine, Ninth Edition, offers a balanced view of the most current knowledge of cancer science and clinical oncology practice. This all-new edition is the consummate reference source for medical oncologists, radiation oncologists, internists, surgical oncologists, and others who treat cancer patients. A translational perspective throughout, integrating cancer biology with cancer management providing an in depth understanding of the disease An emphasis on multidisciplinary, research-driven patient care to improve outcomes and optimal use of all appropriate therapies Cutting-edge coverage of personalized cancer care, including molecular diagnostics and therapeutics Concise, readable, clinically relevant text with algorithms, guidelines and insight into the use of both conventional and novel drugs Includes free access to the Wiley Digital Edition providing search across the book, the full reference list with web links, illustrations and photographs, and post-publication updates

Hypercalcemia of Malignancy

Hypercalcemia of Malignancy
Author: Friedhelm Raue
Publsiher: Springer Science & Business Media
Total Pages: 163
Release: 2012-12-06
Genre: Medical
ISBN: 9783642850738

Download Hypercalcemia of Malignancy Book in PDF, Epub and Kindle

Hypercalcemia is the most common life-threatening metabolic disorder associated with cancer. The pathophysiological, epidemiological and clinical aspects of hypercalcemia of malignancy are presented in this issue, with a focus on the recently discovered humoral factor responsible for the development of hypercalcemia. With a better understanding of the pathophysiology of this condition and the development of new potent drugs, capable of inhibiting bone resorption, especially bisphosphonates, the clinician will be more successful in correcting hypercalcemia in the great majority of patients.

Diagnostic Pathology Bone

Diagnostic Pathology  Bone
Author: G. Petur Nielsen,Andrew E Rosenberg
Publsiher: Elsevier Health Sciences
Total Pages: 500
Release: 2017-01-24
Genre: Medical
ISBN: 9780323509275

Download Diagnostic Pathology Bone Book in PDF, Epub and Kindle

Diagnostic Pathology: Bone was designed for practicing pathologists who need access to up-to-date, comprehensive, and concise bone pathology knowledge in one convenient place. It includes the latest diagnostic information in this challenging subspecialty, while its unique image collection serves as an exceptional educational aid. Authored and updated by experts in the field, Diagnostic Pathology: Bone will be an essential guide to understanding bone tumor pathology and diagnosis. Features quick-reference test data tables and diagnoses of various bone and cartilage tumor types Templated page layout, bulleted text, and a generous number of high-quality images for point-of-care clinical reference Stunning image collection includes gross pathology, histopathology, immunohistochemistry, FISH, and correlative radiologic imaging to serve as an exceptional educational aid Brand-new chapters covering Ewing-like sarcomas with specific translocations, other types of vascular tumors of bone (new entities), and tumors of the synovium Includes new molecular pathology diagnostic information for bone tumors and new immunohistochemical antigens to identify bone pathologies

False Hope

False Hope
Author: Richard A. Rettig,Peter D. Jacobson,Cynthia M. Farquhar M.D.,Wade M. Aubry M.D.
Publsiher: Oxford University Press
Total Pages: 368
Release: 2007-01-25
Genre: Medical
ISBN: 0199748241

Download False Hope Book in PDF, Epub and Kindle

In the late 1980s, a promising new treatment for breast cancer emerged: high-dose chemotherapy with autologous bone marrow transplantation or HDC/ABMT. By the 1990s, it had burst upon the oncology scene and disseminated rapidly before having been carefully evaluated. By the time published studies showed that the procedure was ineffective, more than 30,000 women had received the treatment, shortening their lives and adding to their suffering. This book tells of the rise and demise of HDC/ABMT for metastatic and early stage breast cancer, and fully explores the story's implications, which go well beyond the immediate procedure, and beyond breast cancer, to how we in the United States evaluate other medical procedures, especially life-saving ones. It details how the factors that drove clinical use--patient demand, physician enthusiasm, media reporting, litigation, economic exploitation, and legislative and administrative mandates--converged to propel the procedure forward despite a lack of proven clinical effectiveness. It also analyzes the limited effect of technology assessments before randomized clinical trials evaluated decisively the procedure and the ramifications of this system on healthcare today. Sections of the book consider the initial conditions surrounding the emergence of the new breast cancer treatment, the drivers of clinical use, and the struggle for evidence-based medicine. A concluding section considers the significance of the story for our healthcare system.

Abeloff s Clinical Oncology E Book

Abeloff s Clinical Oncology E Book
Author: Martin D. Abeloff,James O. Armitage,John E. Niederhuber,Michael B. Kastan,W. Gillies McKenna
Publsiher: Elsevier Health Sciences
Total Pages: 2592
Release: 2008-06-30
Genre: Medical
ISBN: 9781437720563

Download Abeloff s Clinical Oncology E Book Book in PDF, Epub and Kindle

Carrying on the tradition established by its founding editor, the late Dr. Martin Abeloff, the 4th Edition of this respected reference synthesizes all of the latest oncology knowledge in one practical, clinically focused, easy-to-use volume. It incorporates basic science, pathology, diagnosis, management, outcomes, rehabilitation, and prevention – all in one convenient resource – equipping you to overcome your toughest clinical challenges. What's more, you can access the complete contents of this Expert Consult title online, and tap into its unparalleled guidance wherever and whenever you need it most! Equips you to select the most appropriate tests and imaging studies for diagnosing and staging each type of cancer, and manage your patients most effectively using all of the latest techniques and approaches. Explores all of the latest scientific discoveries' implications for cancer diagnosis and management. Employs a multidisciplinary approach - with contributions from pathologists, radiation oncologists, medical oncologists, and surgical oncologists - for well-rounded perspectives on the problems you face. Offers a user-friendly layout with a consistent chapter format • summary boxes • a full-color design • and more than 1,445 illustrations (1,200 in full color), to make reference easy and efficient. Offers access to the book's complete contents online – fully searchable – from anyplace with an Internet connection. Presents discussions on cutting-edge new topics including nanotechnology, functional imaging, signal transduction inhibitors, hormone modulators, complications of transplantation, and much more. Includes an expanded color art program that highlights key points, illustrates relevant science and clinical problems, and enhances your understanding of complex concepts.

Metastatic Bone Disease

Metastatic Bone Disease
Author: R. Lor Randall
Publsiher: Springer
Total Pages: 368
Release: 2015-12-01
Genre: Medical
ISBN: 9781461456629

Download Metastatic Bone Disease Book in PDF, Epub and Kindle

Providing an integrated approach to the diagnosis and management of patients with metastatic bone disease (MBD), this comprehensive text combines discussion of the pathobiology of the disease with the latest oncological and orthopedic treatment modalities. After opening with an examination of the epidemiology and impact of MBD, the biology of bone metastases are discussed, along with considerations of the tissue of origin. Evaluation, biopsy and medical therapy, including metabolic agents and bio targeting. The heart of the book presents oncological approaches (supportive, radiation and interventional) and principles of orthopedic surgical oncology, with subsequent chapters covering specific anatomy, from the pelvis to the lower extremity and the spine. Chapters on emerging surgical technology and future directions conclude the text and redefine an integrated approach to patient care. Taken together, Metastatic Bone Disease is an excellent resource for orthopedic surgeons and cancer specialists alike.

Hormone Therapy and Replacement in Cancer and Aging related Diseases

Hormone Therapy and Replacement in Cancer and Aging related Diseases
Author: Letícia Rangel,Ian Victor Silva,Paulo Cilas Morais Lyra Junior,Marcele Mattos De Souza,Diandra Zipinotti Dos Santos,Hephzibah Kirubamani
Publsiher: BoD – Books on Demand
Total Pages: 126
Release: 2020-07-22
Genre: Medical
ISBN: 9781789853193

Download Hormone Therapy and Replacement in Cancer and Aging related Diseases Book in PDF, Epub and Kindle

This edited volume, Hormone Therapy and Replacement in Cancer and Aging-related Diseases, is a collection of reviewed and relevant research chapters, offering a comprehensive overview of recent developments in the field of hormone replacement therapy. The book comprises single chapters authored by various researchers and edited by experts active in the hormone replacement therapy research area. All chapters are complete in themselves but united under a common research study topic. This publication aims at providing a thorough overview of the latest research efforts by international authors on hormone replacement therapy, and opens new possible research paths for further novel developments.

HPV and Cancer

HPV and Cancer
Author: James A. Radosevich
Publsiher: Springer Science & Business Media
Total Pages: 198
Release: 2012-12-14
Genre: Medical
ISBN: 9789400754379

Download HPV and Cancer Book in PDF, Epub and Kindle

“HPV and Cancer” is a concise read that covers all aspects of the Human Papilloma Virus as it relates to human cancers. While written by professionals, it design to be understandable by those that are not in the field, yet it has the technical details that professionals want to stay abreast of this changing field. The book starts out the history of HPV and progresses into the molecular biology of the virus and our current understand of the structure and functions of the proteins and genes it encodes. We then look at the dynamic trends of this infectious agent in the human population, how it interacts with human cells, and the role it plays with other organisms to produce both benign and malignant tumors. Lastly, there is a discussion about a new vaccine for HPV and the hopes that are held by many to change the trends with this virus and the associated cancers it produces.

Health Risks of Radon and Other Internally Deposited Alpha Emitters

Health Risks of Radon and Other Internally Deposited Alpha Emitters
Author: National Research Council,Division on Earth and Life Studies,Commission on Life Sciences,Committee on the Biological Effects of Ionizing Radiations
Publsiher: National Academies Press
Total Pages: 624
Release: 1988-02-01
Genre: Science
ISBN: 9780309037891

Download Health Risks of Radon and Other Internally Deposited Alpha Emitters Book in PDF, Epub and Kindle

This book describes hazards from radon progeny and other alpha-emitters that humans may inhale or ingest from their environment. In their analysis, the authors summarize in one document clinical and epidemiological evidence, the results of animal studies, research on alpha-particle damage at the cellular level, metabolic pathways for internal alpha-emitters, dosimetry and microdosimetry of radionuclides deposited in specific tissues, and the chemical toxicity of some low-specific-activity alpha-emitters. Techniques for estimating the risks to humans posed by radon and other internally deposited alpha-emitters are offered, along with a discussion of formulas, models, methods, and the level of uncertainty inherent in the risk estimates.

Clinical Atlas of 3D Printing Bone Reconstruction

Clinical Atlas of 3D Printing Bone Reconstruction
Author: Hyun-Guy Kang
Publsiher: Springer Nature
Total Pages: 442
Release: 2021-06-12
Genre: Medical
ISBN: 9789811620430

Download Clinical Atlas of 3D Printing Bone Reconstruction Book in PDF, Epub and Kindle

This book provides practitioners with comprehensive guidance on the application of 3D printing technology in the bone reconstruction. The 3D printed implants need to be able to maximize function and minimize complications by reinforcing strength and changing shape beyond anatomically identical design. Many of the clinical cases in this book, including pre-operative images, surgical planning, design and fabrication, 3D printing implants and guides, surgery and postoperative images, will suffice to capture the sensation of the 3D printing bone reconstruction. This book is composed of photos with minimum descriptions so that the readers can develop their imaginative view.