Dento Oro Craniofacial Anomalies and Genetics

Dento Oro Craniofacial Anomalies and Genetics
Author: Agnes Bloch-Zupan,Heddie O. Sedano,Crispian Scully
Publsiher: Elsevier
Total Pages: 250
Release: 2012
Genre: Medical
ISBN: 9780124160385

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Dental defects may be the physical expression of genetic defects, and so they can often be seen in a variety of syndromes associated with malformations of organs. However, dental defects are often not recognized, identified, nor characterised despite representing a possible diagnostic sign for an undiagnosed condition. This book addresses this gap by providing an understanding of dental genetics and its developmental biology counterpart. With approximately seventy well-illustrated examples, the authors present the clinical oro-facial manifestations accompanying various syndromes, providing the necessary knowledge for diagnostic purposes, as well as giving insight into recent development for each specific condition. The clarity and format of this book make it an ideal support guide both in the clinic and while conducting research. Comprehensive examination of dento/oro/craniofacial anomalies Well-illustrated examples Presented in a compact, easy to use format

Dento Oro Craniofacial Anomalies and Genetics

Dento Oro Craniofacial Anomalies and Genetics
Author: Agnes Bloch-Zupan,Heddie Sedano,Crispian Scully
Publsiher: Elsevier
Total Pages: 264
Release: 2012-03-21
Genre: Science
ISBN: 9780123914736

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Dental defects may be the physical expression of genetic defects, and so they can often be seen in a variety of syndromes associated with malformations of organs. However, dental defects are often not recognized, identified, nor characterised despite representing a possible diagnostic sign for an undiagnosed condition. This book addresses this gap by providing an understanding of dental genetics and its developmental biology counterpart. With approximately seventy well-illustrated examples, the authors present the clinical oro-facial manifestations accompanying various syndromes, providing the necessary knowledge for diagnostic purposes, as well as giving insight into recent development for each specific condition. The clarity and format of this book make it an ideal support guide both in the clinic and while conducting research. Comprehensive examination of dento/oro/craniofacial anomalies Well-illustrated examples Presented in a compact, easy to use format

Gorlin s Syndromes of the Head and Neck

Gorlin s Syndromes of the Head and Neck
Author: Raoul C. M. Hennekam,Judith E. Allanson,Ian D. Krantz
Publsiher: Oxford University Press, USA
Total Pages: 1452
Release: 2010
Genre: Medical
ISBN: 0195307909

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This classic text covers over 700 different genetic syndromes involving the head and neck, and has established itself as the definitive, comprehensive work on the subject. The discussion covers the phenotype spectrum, epidemiology, mode of inheritance, pathogenesis, and clinical profile of each condition, all of which is accompanied by a wealth of illustrations. The authors are recognized leaders in the field, and their vast knowledge and strong clinical judgment will help readersmake sense of this complex and burgeoning field.As in all fields of genetics, there has been an explosion in the genetics of dysmorphology syndromes, and the authors have completely updated all chapters in light of the discoveries of the Human Genome Project and other ongoing advances. New syndromes have been added and information on existing syndromes has been revised.

Chromatin Signaling and Diseases

Chromatin Signaling and Diseases
Author: Olivier Binda,Martin Ernesto Fernandez-Zapico
Publsiher: Academic Press
Total Pages: 466
Release: 2016-08-06
Genre: Science
ISBN: 9780128026090

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Chromatin Signaling and Diseases covers the molecular mechanisms that regulate gene expression, which govern everything from embryonic development, growth, and human pathologies associated with aging, such as cancer. This book helps researchers learn about or keep up with the quickly expanding field of chromatin signaling. After reading this book, clinicians will be more capable of explaining the mechanisms of gene expression regulation to their patients to reassure them about new drug developments that target chromatin signaling mechanisms. For example, several epigenetic drugs that act on chromatin signaling factors are in clinical trials or even approved for usage in cancer treatments, Alzheimer's, and Huntington's diseases. Other epigenetic drugs are in development to regulate various class of chromatin signaling factors. To keep up with this changing landscape, clinicians and doctors will need to stay familiar with genetic advances that translate to clinical practice, such as chromatin signaling. Although sequencing of the human genome was completed over a decade ago and its structure investigated for nearly half a century, molecular mechanisms that regulate gene expression remain largely misunderstood. An emerging concept called chromatin signaling proposes that small protein domains recognize chemical modifications on the genome scaffolding histone proteins, facilitating the nucleation of enzymatic complexes at specific loci that then open up or shut down the access to genetic information, thereby regulating gene expression. The addition and removal of chemical modifications on histones, as well as the proteins that specifically recognize these, is reviewed in Chromatin Signaling and Diseases. Finally, the impact of gene expression defects associated with malfunctioning chromatin signaling is also explored. Explains molecular mechanisms that regulate gene expression, which governs everything from embryonic development, growth, and human pathologies associated with aging Educates clinicians and researchers about chromatin signaling, a molecular mechanism that is changing our understanding of human pathology Explores the addition and removal of chemical modifications on histones, the proteins that specifically recognize these, and the impact of gene expression defects associated with malfunctioning chromatin signaling Helps researchers learn about the quickly expanding field of chromatin signaling

Ophthalmic Genetic Diseases

Ophthalmic Genetic Diseases
Author: Natario L. Couser
Publsiher: Elsevier
Total Pages: 198
Release: 2018-09-24
Genre: Medical
ISBN: 0323654142

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This book provides current, clinically focused information on more than 400 genetic eye diseases.

Genetics of Bone Biology and Skeletal Disease

Genetics of Bone Biology and Skeletal Disease
Author: Rajesh V. Thakker,Michael P. Whyte,John Eisman,Takashi Igarashi
Publsiher: Academic Press
Total Pages: 634
Release: 2012-12-31
Genre: Medical
ISBN: 9780123878304

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This book identifies and analyzes the genetic basis of bone disorders in humans and demonstrates the utility of mouse models in furthering the knowledge of mechanisms and evaluations of treatments. The book is aimed at all students of bone biology and genetics, and with this in mind, it includes general introductory chapters on genetics and bone biology and more specific disease-orientated chapters, which comprehensively summarize the clinical, genetic, molecular genetic, animal model, functional and molecular pathology, diagnostic, counselling and treatment aspects of each disorder. Saves academic, medical, and pharma researchers time in quickly accessing the very latest details on a broad range of genetic bone issues, as opposed to searching through thousands of journal articles. Provides a common language for bone biologists and geneticists to discuss the development of bone cells and genetics and their interactions in the development of disease Researchers in all areas bone biology and genetics will gain insight into how clinical observations and practices can feed back into the research cycle and will, therefore, be able to develop more targeted genomic and proteomic assays For those clinical researchers who are also MDs, correct diagnosis (and therefore correct treatment) of bone diseases depends on a strong understanding of the molecular basis for the disease.

Epigenetics in Human Disease

Epigenetics in Human Disease
Author: Trygve O. Tollefsbol
Publsiher: Academic Press
Total Pages: 577
Release: 2012
Genre: Medical
ISBN: 9780123884152

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Epigenetics is one of the fastest growing fields of sciences, illuminating studies of human diseases by looking beyond genetic make-up and acknowledging that outside factors play a role in gene expression. The goal of this volume is to highlight those diseases or conditions for which we have advanced knowledge of epigenetic factors such as cancer, autoimmune disorders and aging as well as those that are yielding exciting breakthroughs in epigenetics such as diabetes, neurobiological disorders and cardiovascular disease. Where applicable, attempts are made to not only detail the role of epigenetics in the etiology, progression, diagnosis and prognosis of these diseases, but also novel epigenetic approaches to the treatment of these diseases. Chapters are also presented on human imprinting disorders, respiratory diseases, infectious diseases and gynecological and reproductive diseases. Since epigenetics plays a major role in the aging process, advances in the epigenetics of aging are highly relevant to many age-related human diseases. Therefore, this volume closes with chapters on aging epigenetics and breakthroughs that have been made to delay the aging process through epigenetic approaches. With its translational focus, this book will serve as valuable reference for both basic scientists and clinicians alike. Comprehensive coverage of fundamental and emergent science and clinical usage Side-by-side coverage of the basis of epigenetic diseases and their treatments Evaluation of recent epigenetic clinical breakthroughs

Craniofacial Development

Craniofacial Development
Author: Peter Thorogood,Cheryll Tickle
Publsiher: Unknown
Total Pages: 257
Release: 1988
Genre: Facial bones
ISBN: OCLC:18444810

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Epigenetic Gene Expression and Regulation

Epigenetic Gene Expression and Regulation
Author: Suming Huang,Michael D Litt,C. Ann Blakey
Publsiher: Academic Press
Total Pages: 482
Release: 2015-10-19
Genre: Science
ISBN: 9780128004715

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Epigenetic Gene Expression and Regulation reviews current knowledge on the heritable molecular mechanisms that regulate gene expression, contribute to disease susceptibility, and point to potential treatment in future therapies. The book shows how these heritable mechanisms allow individual cells to establish stable and unique patterns of gene expression that can be passed through cell divisions without DNA mutations, thereby establishing how different heritable patterns of gene regulation control cell differentiation and organogenesis, resulting in a distinct human organism with a variety of differing cellular functions and tissues. The work begins with basic biology, encompasses methods, cellular and tissue organization, topical issues in epigenetic evolution and environmental epigenesis, and lastly clinical disease discovery and treatment. Each highly illustrated chapter is organized to briefly summarize current research, provide appropriate pedagogical guidance, pertinent methods, relevant model organisms, and clinical examples. Reviews current knowledge on the heritable molecular mechanisms that regulate gene expression, contribute to disease susceptibility, and point to potential treatment in future therapies Helps readers understand how epigenetic marks are targeted, and to what extent transgenerational epigenetic changes are instilled and possibly passed onto offspring Chapters are replete with clinical examples to empower the basic biology with translational significance Offers more than 100 illustrations to distill key concepts and decipher complex science

Pharmacoepigenetics

Pharmacoepigenetics
Author: Anonim
Publsiher: Academic Press
Total Pages: 624
Release: 2019-04-15
Genre: Medical
ISBN: 0128139390

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Pharmacoepigenetics, Volume Eleven provides a comprehensive volume on the role of epigenetics and epigenomics in drug discovery and development, providing a detailed, but accessible, view of the field, from basic principles, to applications in disease therapeutics. Leading international researchers from across academia, clinical settings and the pharmaceutical industry discuss the influence of epigenetics and epigenomics in human pathology, epigenetic biomarkers for disease prediction, diagnosis, and treatment, current epigenetic drugs, and the application of epigenetic procedures in drug development. Throughout the book, chapter authors offer a balanced and objective discussion of the future of pharmacoepigenetics and its crucial contribution to the growth of precision and personalized medicine. Fully examines the influence of epigenetics and epigenomics in human pathology, epigenetic biomarkers for disease prediction, diagnosis, treatment, current epigenetic drugs and the application of epigenetic procedures in drug development Features chapter contributions from leading international researchers in academia, clinical settings and the pharmaceutical industry Instructs researchers, students and clinicians on how to better interpret and employ pharmacoepigenetics in drug development, efficiency and safety Provides a balanced and objective discussion of the future of pharmacoepigenetics and its crucial role in precision medicine

Color Atlas of Oral and Maxillofacial Diseases E Book

Color Atlas of Oral and Maxillofacial Diseases   E Book
Author: Brad W. Neville,Douglas D. Damm,Carl M. Allen,Angela C. Chi
Publsiher: Elsevier Health Sciences
Total Pages: 544
Release: 2018-09-26
Genre: Medical
ISBN: 9780323582933

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Introducing an essential new practical atlas for dental students and clinicians alike! The Color Atlas of Oral and Maxillofacial Diseases provides comprehensive, practical information on the most common oral and maxillofacial diseases and disorders. This new text uses a quick-access atlas format to help you easily look up clinical signs, diagnosis, and treatments. Nearly 750 high-quality images accompanied by brief narratives demonstrate exactly what clinical signs to look for – making an intervention as timely as possible. Written by four of the top dental authorities in the world, this concise resource is sure to become a clinical favorite. NEW! Quick-access atlas format makes it easy to look up clinical signs, diagnosis, and treatment of oral and maxillofacial diseases NEW! Nearly 750 high-quality radiographs and color clinical photos facilitate the identification of lesions and diseases. NEW! Comprehensive, focused coverage highlight diseases that may affect the oral and maxillofacial regions. NEW! Full-color design and illustrations. NEW! Logical organization reflects the sequence in which content is generally presented to predoctoral students

The Teeth of Non Mammalian Vertebrates

The Teeth of Non Mammalian Vertebrates
Author: Barry K. B. Berkovitz,R.P Shellis
Publsiher: Academic Press
Total Pages: 354
Release: 2016-10-14
Genre: Science
ISBN: 9780128028841

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The Teeth of Non-Mammalian Vertebrates is the first comprehensive publication devoted to the teeth and dentitions of living fishes, amphibians and reptiles. The book presents a comprehensive survey of the amazing variety of tooth forms among non-mammalian vertebrates, based on descriptions of approximately 400 species belonging to about 160 families. The text is lavishly illustrated with more than 600 high-quality color and monochrome photographs of specimens gathered from top museums and research workers from around the world, supplemented by radiographs and micro-CT images. This stimulating work discusses the functional morphology of feeding, the attachment of teeth, and the relationship of tooth form to function, with each chapter accompanied by a comprehensive, up-to-date reference list. Following the descriptions of the teeth and dentitions in each class, four chapters review current topics with considerable research activity: tooth development; tooth replacement; and the structure, formation and evolution of the dental hard tissues. This timely book, authored by internationally recognized teachers and researchers in the field, also reflects the resurgence of interest in the dentitions of non-mammalian vertebrates as experimental systems to help understand genetic changes in evolution of teeth and jaws. Features more than 600 images, including numerous high-quality photographs from internationally-recognized researchers and world class collections Offers guidance on tooth morphology for classification and evolution of vertebrates Provides detailed coverage of the dentition of all living groups of non-mammalian vertebrates

Genetic Diagnosis of Endocrine Disorders

Genetic Diagnosis of Endocrine Disorders
Author: Roy E. Weiss,Samuel Refetoff
Publsiher: Academic Press
Total Pages: 472
Release: 2015-10-09
Genre: Medical
ISBN: 9780128011348

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Genetic Diagnosis of Endocrine Disorders, Second Edition provides users with a comprehensive reference that is organized by endocrine grouping (i.e., thyroid, pancreas, parathyroid, pituitary, adrenal, and reproductive and bone), discussing the genetic and molecular basis for the diagnosis of various disorders. The book emphasizes the practical nature of diagnosing a disease, including which tests should be done for the diagnosis of diabetes mellitus in adults and children, which genes should be evaluated for subjects with congenital hypothyroidism, which genetic tests should be ordered in obese patients or for those with parathyroid carcinoma, and the rationale behind testing for multiple endocrine neoplasias. Offers a clear presentations of pharmacogenetics and the actual assays used in detecting endocrine diseases Teaches the essentials of the genetic basis of disease in each major endocrine organ system Offers expert advice from genetic counselors on how to use genetic information in counseling patients Includes new chapters on the genetics of lipid disorders and glycogen storage diseases, genetics of hypoglycemia, and whole genome/exome sequencing

Ion Channel Diseases

Ion Channel Diseases
Author: Anonim
Publsiher: Academic Press
Total Pages: 168
Release: 2011-09-06
Genre: Science
ISBN: 0080923100

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Ion channel dysfunction in humans leads to impairment of the excitable processes necessary for the normal function of several tissues, such as muscle and brain. It follows that an increasing number of human diseases have been associated with malfunctioning ion channels, many of which have a genetic component. This volume of Advances in Genetics presents a broad and comprehensive overview of the inherited channelopathies in humans, including clinical, genetic and molecular aspects of these conditions. Keeping true to the scope of the serial, novel genomic and modeling research approaches and a review of potential therapeutic approaches for each of these conditions are also incorporated.

Handbook of Pediatric Dentistry E Book

Handbook of Pediatric Dentistry E Book
Author: Angus C. Cameron,Richard P. Widmer
Publsiher: Elsevier Health Sciences
Total Pages: 512
Release: 2013-07-10
Genre: Medical
ISBN: 9780702054280

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The new edition of this internationally recognised text offers comprehensive guidance on the successful management of the child in the dental setting. Prepared by authors of international renown, the Handbook of Paediatric Dentistry presents a volume that takes the reader far beyond the technical skills that are needed to treat disorders of the childhood dentition and instead delivers a whole philosophy of integrative patient care. Richly illustrated and in full colour throughout, the Handbook of Paediatric Dentistry is written in a friendly ‘how to’ manner and contains useful ‘pull out’ boxes to act as useful aide-mémoires. Exploring a variety of topics, the book includes discussion of child development, practical communication skills and advice on how to deal with behavioural problems. Clinical topics include the management of caries, fluoridation, restorative dentistry, pulp therapy, trauma management, oral medicine and pathology, dental anomalies, and the treatment of medically compromised children. Chapters also explore the use of orthodontics, the management of cleft lip and palate and speech, language and swallowing. The Handbook of Paediatric Dentistry has become an essential chairside and bedside companion for all practitioners caring for children and is suitable for undergraduate dental students, general dental practitioners, specialist paediatric dentists, orthodontists and paediatricians. Established as the foremost available comprehensive handbook on paediatric dentistry Prepared in an ‘easy-to-digest’ fashion – which allows for quick reference and easy reading Contains over 550 full colour line artworks, photographs and tables together with ‘Clinical Hints’ boxes to act as useful aide-mémoires Sets out the essentials for managing conditions such as clefting disorders, haematological and endocrine disorders, congenital cardiac disease, disorders of metabolism, organ transplantation and cancer in children as well as more familiar presentations such as dental trauma, oral infections and caries Detailed appendices provide the reader with information that is often difficult to find and which may be overlooked Designed specifically to give all practitioners confidence when managing children Convenient handbook size ensures that the book can be easily referred to in the clinical setting Endorsed by the Australasian Academy of Paediatric Dentistry ~ Improved layout and completely new colour illustrations Expanded section on sedation and use of nitrous oxide Includes details from the most recent international guidelines Cases expanded to show 20 year follow-up Includes the latest research findings in orthodontics Fully updated section on clefting problems