Drugs and the Future

Drugs and the Future
Author: David J. Nutt,Trevor W. Robbins,Gerald V. Stimson,Martin Ince,Andrew Jackson
Publsiher: Elsevier
Total Pages: 616
Release: 2006-12-11
Genre: Psychology
ISBN: 0080467741

Download Drugs and the Future Book in PDF, Epub and Kindle

Drugs and the Future presents 13 reviews collected to present the new advances in all areas of addiction research, including knowledge gained from mapping the human genome, the improved understanding of brain pathways and functions that are stimulated by addictive drugs, experimental and clinical psychology approaches to addiction and treatment, as well as both ethical considerations and social policy. The book also includes chapters on the history of addictive substances and some personal narratives of addiction. Introduced by Sir David King, Science Advisory to the UK Government and head of the Office of Science and Technology, and Nora Volkow, director of the National Institute on Drug Abuse in the USA, the book uniquely covers the full range of disciplines which can provide insight into the future of addiction, from genetics to the humanities. Written for a scientific audience, it is also applicable to non-specialists as well. Provides an unique overview of what we know about addiction, and how scientific knowledge can and should be applied in the societal, ethical, and political context Applies the state-of-the-art research in fields such as Genomics, Neuroscience, Pharmacology, Social Policy and Ethics to addiction research Includes a preface by Sir David King, Science Advisory to the UK Government and head of the Office of Science and Technology, and in introduction by Nora Volkow, director of the National Institute on Drug Abuse in the USA

The Future of Drug Discovery

The Future of Drug Discovery
Author: Tamas Bartfai,Graham V. Lees
Publsiher: Academic Press
Total Pages: 376
Release: 2013-05-18
Genre: Medical
ISBN: 9780124095199

Download The Future of Drug Discovery Book in PDF, Epub and Kindle

The Future of Drug Discovery: Who decides which diseases to treat? provides a timely and detailed look at the efforts of the pharmaceutical industry and how they relate, or should relate, to societal needs. The authors posit that as a result of increasing risk aversion and accelerated savings in research and development, the industry is not developing drugs for increasingly prevalent diseases, such as Alzheimer’s disease, untreatable pain, antibiotics and more. This book carefully exposes the gap between the medicines and therapies we need and the current business path. By analyzing the situation and discussing prospects for the next decade, the The Future of Drug Discovery is a timely book for all those who care about the development needs for drugs for disease. Provides an in-depth, broad perspective on the crisis in drug industry Exposes the disconnect between what society needs and what the drug companies are working on Analyses and projects over 10 years into the future Explains what it means for scientists and society Determines what is needed to be done to make sure that the industry responds to society's needs, remains commercially attractive and answers the question as to who decides which diseases to treat

Undoing Drugs

Undoing Drugs
Author: Maia Szalavitz
Publsiher: Hachette Go
Total Pages: 304
Release: 2021-07-27
Genre: Social Science
ISBN: 9780738285757

Download Undoing Drugs Book in PDF, Epub and Kindle

“Of the countless writers out there whose focus is addiction, no one can begin to touch the brilliance of Maia Szalavitz.” —Kristen Johnston, actress, author of the New York Times bestselling memoir Guts, addiction advocate, founder of SLAM NYC Drug overdoses now kill more Americans annually than guns, cars, or breast cancer. But the United States has tried to solve this national crisis with policies that only made matters worse. In the name of “sending the right message,” we have maximized the spread of infectious disease, torn families apart, incarcerated millions of mostly Black and Brown people—and utterly failed to either prevent addiction or make effective treatment for it widely available. There is another way—one that is proven to work. However it runs counter to much of the received wisdom about substances and related problems. It is called harm reduction. Created by a group of people who use drugs and by radical public health experts, harm reduction offers a new way of thinking—one that provides startling insights into behavioral and cultural issues that go far beyond drugs. In a spellbinding narrative rooted in an urgent call to action, Undoing Drugs tells the untold tale of a quirky political movement that has unexpectedly shaken the foundations of world drug policy. It illustrates how hard it can be to take on widely accepted conventional thinking—and what is necessary to overcome this resistance. Ultimately, Undoing Drugs offers a path forward—led by characters who spent many years being dismissed as worthless, only to develop a breakthrough philosophy that can dramatically improve world health.

Love is the Drug

Love is the Drug
Author: Brian D. Earp,Julian Savulescu
Publsiher: Manchester University Press
Total Pages: 280
Release: 2020-01-30
Genre: Science
ISBN: 9781526145567

Download Love is the Drug Book in PDF, Epub and Kindle

What if there were a pill for love? Or an anti-love drug, designed to help us break up? This controversial and timely new book argues that recent medical advances have brought chemical control of our romantic lives well within our grasp. Substances affecting love and relationships, whether prescribed by doctors or even illicitly administered, are not some far-off speculation – indeed our most intimate connections are already being influenced by pills we take for other purposes, such as antidepressants. Treatments involving certain psychoactive substances, including MDMA—the active ingredient in Ecstasy—might soon exist to encourage feelings of love and help ordinary couples work through relationship difficulties. Others may ease a breakup or soothe feelings of rejection. Such substances could have transformative implications for how we think about and experience love. This brilliant intervention into the debate builds a case for conducting further research into "love drugs" and "anti-love drugs" and explores their ethical implications for individuals and society. Rich in anecdotal evidence and case-studies, the book offers a highly readable insight into a cutting-edge field of medical research that could have profound effects on us all. Will relationships be the same in the future? Will we still marry? It may be up to you to decide whether you want a chemical romance.

Drug Repositioning Current Advances and Future Perspectives

Drug Repositioning  Current Advances and Future Perspectives
Author: Yuhei Nishimura,Hideaki Hara
Publsiher: Frontiers Media SA
Total Pages: 135
Release: 2019-01-11
Genre: Electronic Book
ISBN: 9782889456963

Download Drug Repositioning Current Advances and Future Perspectives Book in PDF, Epub and Kindle

Drug repositioning is the process of identifying new indications for existing drugs. At present, the conventional de novo drug discovery process requires an average of about 14 years and US$2.5 billion to approve and launch a drug. Drug repositioning can reduce the time and cost of this process because it takes advantage of drugs already in clinical use for other indications or drugs that have cleared phase I safety trials but have failed to show efficacy in the intended diseases. Historically, drug repositioning has been realized through serendipitous clinical observations or improved understanding of disease mechanisms. However, recent technological advances have enabled a more systematic approach to drug repositioning. This eBook collects 16 articles from 112 authors, providing readers with current advances and future perspectives of drug repositioning.

Out of Nature

Out of Nature
Author: Kara Rogers
Publsiher: University of Arizona Press
Total Pages: 216
Release: 2012-11-01
Genre: Science
ISBN: 9780816599585

Download Out of Nature Book in PDF, Epub and Kindle

About half of all species under threat of extinction in the world today are plants. The loss of plant biodiversity is disturbing for many reasons, but especially because it is a reflection of the growing disconnect between humans and nature. Plants have been used for millennia in traditional systems of healing and have held a significant place in drug development for Western medicine as well. Despite the recent dominance of synthetic drug production, natural product discovery remains the backbone of drug development. As the diversity of life on Earth is depleted and increasing numbers of species become lost to extinction, we continue to lose opportunities to achieve advances in medicine. Through stories of drug revelation in nature and forays into botany, human behavior, and conservation, Kara Rogers sheds light on the multiple ways in which humans, medicine, and plants are interconnected. With accessible and engaging writing, she explores the relationships between humans and plants, relating the stories of plant hunters of centuries past and examining the impact of human activities on the environment and the world's biodiversity. Rogers also highlights the role that plant-based products can play in encouraging conservation and protecting the heritage and knowledge of indigenous peoples. Out of Nature provides a fresh perspective on modern drug innovation and its relationship with nature. The book delves into the complexity of biophilia--the innate human attraction to life in the natural world--and suggests that the reawakening of this drive is fundamental to expanding conservation efforts and improving medicine. Rogers's examination of plants, humans, and drug discovery also conveys a passionate optimism for the future of biodiversity and medicine. Including a collection of hand-drawn maps and plant illustrations created by the author, this well-researched narrative will inspire as well as inform.

Medicinal Plants

Medicinal Plants
Author: Parimelazhagan Thangaraj
Publsiher: CRC Press
Total Pages: 382
Release: 2018-03-29
Genre: Health & Fitness
ISBN: 9781351046503

Download Medicinal Plants Book in PDF, Epub and Kindle

This book highlights the importance of traditional medicines, focuses on the standardization of herbal medicine and evaluates opportunities for advancing drug research. It addresses issues in utilization of medicinal plants and shares the importance of herbs in neutraceutics. It provides most competitive techniques being used in research.

Ethnopharmacology of Medicinal Plants

Ethnopharmacology of Medicinal Plants
Author: Christophe Wiart
Publsiher: Springer Science & Business Media
Total Pages: 228
Release: 2007-11-04
Genre: Medical
ISBN: 9781597451604

Download Ethnopharmacology of Medicinal Plants Book in PDF, Epub and Kindle

In 1860, Oliver Wendell Holmes pointedly expressed himself to the Massachusetts Medical Society: “I firmly believe that if the whole Material Medica, as now used, could be sunk to the bottom of the sea, it would be all the better for mankind, and all the worst for the fishes.” Should one think the same about the current approach in drug discovery from plants? Probably yes. Despite the spending of billions of US dollars, and three decades of efforts, high-throughput screenings have only allowed the discovery of a couple of drugs. One could have reasonably expected the discovery of an arsenal of drugs from the millions of plant extracts randomly tested, but “hits” can be inactive in vitro or too toxic, some molecules need to be metabolized first to be active, and false-positive and false-negative results are common. The bitter truth is that the robotic approach in discovering drugs from plants has proven, to date, its inability to excavate the hundreds of molecules that will contribute to the health progress of Man. However, one can reasonably see that the last patches of primary rainforest on earth hold still hundreds of spectacularly active drugs that await discovery.

Relationships Among the Brain the Digestive System and Eating Behavior

Relationships Among the Brain  the Digestive System  and Eating Behavior
Author: Institute of Medicine,Food and Nutrition Board,Food Forum
Publsiher: National Academies Press
Total Pages: 134
Release: 2015-02-27
Genre: Medical
ISBN: 9780309366861

Download Relationships Among the Brain the Digestive System and Eating Behavior Book in PDF, Epub and Kindle

On July 9-10, 2014, the Institute of Medicine's Food Forum hosted a public workshop to explore emerging and rapidly developing research on relationships among the brain, the digestive system, and eating behavior. Drawing on expertise from the fields of nutrition and food science, animal and human physiology and behavior, and psychology and psychiatry as well as related fields, the purpose of the workshop was to (1) review current knowledge on the relationship between the brain and eating behavior, explore the interaction between the brain and the digestive system, and consider what is known about the brain's role in eating patterns and consumer choice; (2) evaluate current methods used to determine the impact of food on brain activity and eating behavior; and (3) identify gaps in knowledge and articulate a theoretical framework for future research. Relationships among the Brain, the Digestive System, and Eating Behavior summarizes the presentations and discussion of the workshop.

Phenotypic Drug Discovery

Phenotypic Drug Discovery
Author: Angelique Augustin,Beverley Isherwood
Publsiher: Royal Society of Chemistry
Total Pages: 245
Release: 2020-12-10
Genre: Medical
ISBN: 9781788018760

Download Phenotypic Drug Discovery Book in PDF, Epub and Kindle

Phenotypic drug discovery has been highlighted in the past decade as an important strategy in the discovery of new medical entities. How many marketed drugs are derived from phenotypic screens? From the most recent examples, what were the factors enabling target identification and validation? This book answers these questions by elaborating on fundamental capabilities required for phenotypic drug discovery and using case studies to illustrate approaches and key success factors. Written and edited by experienced practitioners from both industry and academia, this publication will equip researchers with a thought-provoking guide to the application and future development of contemporary phenotypic drug discovery for clinical success.

Drug Discovery and Development

Drug Discovery and Development
Author: Vishwanath Gaitonde,Partha Karmakar,Ashit Trivedi
Publsiher: BoD – Books on Demand
Total Pages: 164
Release: 2020-03-11
Genre: Medical
ISBN: 9781789239751

Download Drug Discovery and Development Book in PDF, Epub and Kindle

The process of drug discovery and development is a complex multistage logistics project spanned over 10-15 years with an average budget exceeding 1 billion USD. Starting with target identification and synthesizing anywhere between 10k to 15k synthetic compounds to potentially obtain the final drug that reaches the market involves a complicated maze with multiple inter- and intra-operative fields. Topics described in this book emphasize the progresses in computational applications, pharmacokinetics advances, and molecular modeling developments. In addition the book also contains special topics describing target deorphaning in Mycobacterium tuberculosis, therapy treatment of some rare diseases, and developments in the pediatric drug discovery process.

Drugs Brains and Behavior

Drugs  Brains  and Behavior
Author: Anonim
Publsiher: Unknown
Total Pages: 29
Release: 2007
Genre: Brain
ISBN: MINN:31951D025861296

Download Drugs Brains and Behavior Book in PDF, Epub and Kindle

"Drugs, Brains, and Behavior" is an online textbook written by C. Robin Timmons and Leonard W. Hamilton. The book was previously published by Prentice Hall, Inc. in 1990 as "Principles of Behavioral Pharmacology." The authors attempt to develop an understanding of the interpenetration of brain, behavior and environment. They discuss the chemistry of behavior in both the literal sense of neurochemistry and the figurative sense of an analysis of the reactions with the environment.

Drug Discovery Targeting Drug Resistant Bacteria

Drug Discovery Targeting Drug Resistant Bacteria
Author: Prashant Kesharwani,Sidharth Chopra,Arunava Dasgupta
Publsiher: Academic Press
Total Pages: 432
Release: 2020-05-15
Genre: Business & Economics
ISBN: 9780128184813

Download Drug Discovery Targeting Drug Resistant Bacteria Book in PDF, Epub and Kindle

Drug Discovery Targeting Drug-Resistant Bacteria explores the status and possible future of developments in fighting drug-resistant bacteria. The book covers the majority of microbial diseases and the drugs targeting them. In addition, it discusses the potential targeting strategies and innovative approaches to address drug resistance. It brings together academic and industrial experts working on discovering and developing drugs targeting drug-resistant (DR) bacterial pathogens. New drugs active against drug-resistant pathogens are discussed, along with new strategies being used to discover molecules acting via new modes of action. In addition, alternative therapies such as peptides and phages are included. Pharmaceutical scientists, microbiologists, medical professionals, pathologists, researchers in the field of drug discovery, infectious diseases and microbial drug discovery both in academia and in industrial settings will find this book helpful. Written by scientists with extensive industrial experience in drug discovery Provides a balanced view of the field, including its challenges and future directions Includes a special chapter on the identification and development of drugs against pathogens which exhibit the potential to be used as weapons of war

Drugs and Thugs

Drugs and Thugs
Author: Russell Crandall
Publsiher: Yale University Press
Total Pages: 520
Release: 2020-10-27
Genre: Political Science
ISBN: 9780300255874

Download Drugs and Thugs Book in PDF, Epub and Kindle

A sweeping and highly readable work on the evolution of America’s domestic and global drug war How can the United States chart a path forward in the war on drugs? In Drugs and Thugs, Russell Crandall uncovers the full history of this war that has lasted more than a century. As a scholar and a high-level national security advisor to both the George W. Bush and Obama administrations, he provides an essential view of the economic, political, and human impacts of U.S. drug policies. Backed by extensive research, lucid and unbiased analysis of policy, and his own personal experiences, Crandall takes readers from Afghanistan to Colombia, to Peru and Mexico, to Miami International Airport and the border crossing between El Paso and Juarez to trace the complex social networks that make up the drug trade and drug consumption. Through historically driven stories, Crandall reveals how the war on drugs has evolved to address mass incarceration, the opioid epidemic, the legalization and medical use of marijuana, and America’s shifting foreign policy.

Computer Applications in Drug Discovery and Development

Computer Applications in Drug Discovery and Development
Author: Puratchikody, A.,Prabu, S. Lakshmana,Umamaheswari, A.
Publsiher: IGI Global
Total Pages: 332
Release: 2018-11-23
Genre: Medical
ISBN: 9781522573272

Download Computer Applications in Drug Discovery and Development Book in PDF, Epub and Kindle

With more restrictions upon animal experimentations, pharmaceutical industries are currently focusing on a new generation of experiments and technologies that are considerably more efficient and less controversial. The integration of computational and experimental strategies has led to the identification and development of promising compounds. Computer Applications in Drug Discovery and Development is a pivotal reference source that provides innovative research on the application of computers for discovering and designing new drugs in modern molecular biology and medicinal chemistry. While highlighting topics such as chemical structure databases and dataset utilization, this publication delves into the current panorama of drug discovery, where high drug failure rates are a major concern and properly designed virtual screening strategies can be a time-saving, cost-effective, and productive alternative. This book is ideally designed for chemical engineers, pharmacists, molecular biologists, students, researchers, and academicians seeking current research on the unexplored avenues and future perspectives of drug design.