Genome Chaos

Genome Chaos
Author: Henry H. Heng
Publsiher: Academic Press
Total Pages: 556
Release: 2019-05-25
Genre: Medical
ISBN: 9780128136362

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Genome Chaos: Rethinking Genetics, Evolution, and Molecular Medicine transports readers from Mendelian Genetics to 4D-genomics, building a case for genes and genomes as distinct biological entities, and positing that the genome, rather than individual genes, defines system inheritance and represents a clear unit of selection for macro-evolution. In authoring this thought-provoking text, Dr. Heng invigorates fresh discussions in genome theory and helps readers reevaluate their current understanding of human genetics, evolution, and new pathways for advancing molecular and precision medicine. Bridges basic research and clinical application and provides a foundation for re-examining the results of large-scale omics studies and advancing molecular medicine Gathers the most pressing questions in genomic and cytogenomic research Offers alternative explanations to timely puzzles in the field Contains eight evidence-based chapters that discuss 4d-genomics, genes and genomes as distinct biological entities, genome chaos and macro-cellular evolution, evolutionary cytogenetics and cancer, chromosomal coding and fuzzy inheritance, and more

Intratumor Diversity and Clonal Evolution in Cancer

Intratumor Diversity and Clonal Evolution in Cancer
Author: David Gisselsson
Publsiher: Academic Press
Total Pages: 368
Release: 2011-09-29
Genre: Medical
ISBN: 9780123877086

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This specialized volume of Advances in Cancer Research is dedicated to the complex and largely unexplored field of intratumor diversity, with respect to differences in both genotype and phenotype among cell populations within tumors. Unique subject matter: there are relatively few previous publications covering this complex topic, even though it has been a matter of much speculation ever since cancers were first studied under the microscope more than a century ago. This volume is an attempt to update the reader on novel findings as well as giving a historical perspective to the field. It thereby offers an excellent starting point for young scientists entering this field of research Contributors: many of the contributors are renowned cancer researchers with long-term experience. To bring in new ideas to the field, these experienced authors have been blended with young bright minds who might provide novel starting points for solving old problems Technical aspects: some chapters will be focused on specific techniques to address intratumor diversity and will therefore be helpful for colleagues wanting to broaden their technical expertise

Chromosome Biology as a Key to Understand Disease Mechanisms Genome Architecture and Evolution

Chromosome Biology as a Key to Understand Disease Mechanisms  Genome Architecture and Evolution
Author: Anja Weise,Philipp G. Maass,Ron Hochstenbach
Publsiher: Frontiers Media SA
Total Pages: 135
Release: 2021-04-16
Genre: Science
ISBN: 9782889666812

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This topic has been realized, and is in collaboration with Dr. Constanze Pentzold, Post Doctoral Researcher at the Institute of Human Genetics, University Hospital Jena.

Debating Cancer

Debating Cancer
Author: Henry H Heng
Publsiher: World Scientific
Total Pages: 464
Release: 2015-10-08
Genre: Science
ISBN: 9789814520867

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Cancer research is at a crossroads. Traditionally, cancer has been thought of as a disease of gene mutation, where the stepwise accumulation of cancer gene mutations is the key, and the identification of common gene mutations has been considered to be essential for diagnosis and treatment. Despite extensive research efforts and accumulated knowledge on cancer genes and pathways, the clinical benefits of this traditional approach have been limited. Recently, cancer genome sequencing has revealed an extensive amount of genetic heterogeneity where the long-expected common mutation drivers have been difficult, if not impossible, to identify. These realities ultimately challenge the conceptual framework of current cancer biology. This book introduces a new concept of genome theory of cancer evolution, in an attempt to unify the field. Many important and representative, but often confusing, questions and paradoxes are critically analyzed. By comparing gene- and genome-based theories, the hidden flaws of many popular viewpoints are addressed. This discussion is intended to initiate a much-needed critical re-evaluation of current cancer research. Contents:Introduction: Why Debate Cancer, and Why Now?The Gene Mutation Theory of CancerAlternative Theories to Explain CancerThe Surprise Cancer Genome Landscape Revealed by Cancer Genome Sequencing ProjectsUnraveling the Mystery of Cancer: Understanding Genome Variation Mediated Cancer EvolutionSignificance of the Insignificant: Why "Noise" is Essential for Cancer EvolutionDo Different Cancers Represent Different Species?Facts vs. Myths Readership: This book will be appreciated by the research community at large. It will also serve as an excellent resource for a wide range of readers, including researchers, graduate students, physicians, science reporters, and even policy-makers. Key Features:Currently, there exists no such book. This title represents a much-needed effort to systematically re-examine many concepts in cancer research which have remained relatively the same for decadesThe topics discussed are well-known paradoxes to researchers (over 50 of them). Addressing these questions will not only provide answers to key puzzles in the field but also introduce a new conceptual framework, the genome-based cancer evolution theoryThis book will encourage new ideas/approaches that bridge basic research and clinical applications. The analysis of provocative questions will spur a long overdue debate on this subjectKeywords:Cancer Evolution;Genome Theory;Cancer Heterogeneity;Cancer Landscape;Cancer Theories;Drug Resistance;Cancer Diagnosis;Cancer Research

Human Interphase Chromosomes

Human Interphase Chromosomes
Author: Yuri B. Yurov,Svetlana G. Vorsanova,Ivan Y. Iourov
Publsiher: Springer Science & Business Media
Total Pages: 216
Release: 2013-04-03
Genre: Medical
ISBN: 9781461465584

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This title will focus on the study of human interphase chromosomes and its relation to health and disease. Orchestrated organization and human genome function in interphase nuclei at the chromosomal level have been repeatedly shown to play a significant role in a variety of basic biological processes involved in realization and inheritance of genetic information within and between species. Current biomedical sciences of post-genomic era refocus basic and applied studies of interphase nuclei genetics and genomics with special attention to interphase chromosome behavior in health and disease. Additionally, related processes are a target of studies elucidating the role of interphase chromosome behavior during development, chromosome/DNA replication, DNA reparation etc. Studies of interphase nuclei have an appreciable impact on different areas of biomedical sciences such as cell biology, neurobiology, cancer research, developmental biology, epigenetics, cytogenetics, and medical genetics, as a whole. Moreover, development of innovative and emergent technologies to analyze interphase nuclei are closely associated with application of these techniques in clinical, diagnostic and research practice to solve reproductive problems (including infertility and spontaneous abortions), to investigate congenital malformations (including those produced by aneuploidy and other chromosome abnormalities); genetic diseases (including cardiac, immune, neurological and psychiatric diseases), and cancer. This title will serve as a source of new valuable information and promising ideas for a wide audience of professionals in biomedicine including researchers, scientists, and healthcare professionals in human genetics, cytogenetics, and developmental biology. ‚Äč

Embracing Complexity in Health

Embracing Complexity in Health
Author: Joachim P. Sturmberg
Publsiher: Springer
Total Pages: 335
Release: 2019-05-16
Genre: Medical
ISBN: 9783030109400

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This detailed volume illustrates the transformative nature of systems and complexity sciences for practice, research, education, and health system organization. Researchers highlight the fresh perspectives and novel approaches offered by these interdisciplinary fields in addressing the complexities of global, national, and community health challenges in the 21st century. With the implications that these emerging fields hold for health still relatively underexplored, researchers from a wide variety of disciplines, including physiological, social, environmental, clinical, prevention, educational, organizational, finance, and policy domains, aim in this book to suggest future directions in health care and highlight recent advances in basic and clinical physiology, education, policy-making, and leadership. Among the topics discussed: Impact of genomic heterogeneity on bio-emergent properties Harnessing Big Data to improve health services Decision-making of women in violent relationships Co-producing healthcare interventions A socio-ecological solution to physician burnout Embracing Complexity in Health: The Transformation of Science, Practice, and Policy is a highly relevant resource to practitioners in the field, students, instructors, and policy makers, and also should find an engaged audience among health and disease researchers, healthcare planners, health system financiers, health system administrators, health services administrators, health professional educators, and other health professionals. The trans- and interdisciplinary natures of health and health care are fostering a broad discourse amongst all concerned with improving patient care in an equitable and sustainable way.

Ecology and Evolution of Cancer

Ecology and Evolution of Cancer
Author: Beata Ujvari,Benjamin Roche,Frederic Thomas
Publsiher: Academic Press
Total Pages: 290
Release: 2017-02-08
Genre: Medical
ISBN: 9780128043806

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Ecology and Evolution of Cancer is a timely work outlining ideas that not only represent a substantial and original contribution to the fields of evolution, ecology, and cancer, but also goes beyond by connecting the interfaces of these disciplines. This work engages the expertise of a multidisciplinary research team to collate and review the latest knowledge and developments in this exciting research field. The evolutionary perspective of cancer has gained significant international recognition and interest, which is fully understandable given that somatic cellular selection and evolution are elegant explanations for carcinogenesis. Cancer is now generally accepted to be an evolutionary and ecological process with complex interactions between tumor cells and their environment sharing many similarities with organismal evolution. As a critical contribution to this field of research the book is important and relevant for the applications of evolutionary biology to understand the origin of cancers, to control neoplastic progression, and to prevent therapeutic failures. Covers all aspects of the evolution of cancer, appealing to researchers seeking to understand its origins and effects of treatments on its progression, as well as to lecturers in evolutionary medicine Functions as both an introduction to cancer and evolution and a review of the current research on this burgeoning, exciting field, presented by an international group of leading editors and contributors Improves understanding of the origin and the evolution of cancer, aiding efforts to determine how this disease interferes with biotic interactions that govern ecosystems Highlights research that intends to apply evolutionary principles to help predict emergence and metastatic progression with the aim of improving therapies

Atlas of Hematopathology

Atlas of Hematopathology
Author: Faramarz Naeim,P. Nagesh Rao,Sophie X. Song,Ryan T. Phan
Publsiher: Academic Press
Total Pages: 984
Release: 2018-06-22
Genre: Science
ISBN: 9780128098448

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Atlas of Hematopathology: Morphology, Immunophenotype, Cytogenetics, and Molecular Approaches, Second Edition, will appeal to both a wide range of people undergoing training in a variety of medical fields and practicing non-hematopathologists. For clinicians, fellows and residents, correct diagnosis (and therefore correct treatment) of diseases depends on a strong understanding of the molecular basis for the disease, making this book a crucial resource. This atlas contains hundreds of high-quality color images that mirror the findings that fellows and clinicians encounter in practice. In addition, it provides information in a quick, simple and user-friendly manner, attracting both those in training and non- experts. Residents, fellows, practicing clinicians, and researchers in pathology, hematology and hematology/oncology will find this a useful resource. Covers both non-neoplastic hematopathology and neoplastic hematopathology in all organs and tissues Demonstrates results of important complementary diagnostic tests, such as immunophenotyping (immunohistochemical stains and flow cytometry), karyotyping, FISH and DNA/molecular studies Provides tables to summarize the most important clinicopathological features Saves clinicians and researchers time in quickly accessing the very latest details on the diverse clinical and scientific aspects of hematopathology