Micro And Nanoengineering Of The Cell Surface

Micro- and Nanoengineering of the Cell Surface explores the direct engineering of cell surfaces, enabling materials scientists and chemists to manipulate or augment cell functions and phenotypes. The book is accessible for readers across industry, academia, and in clinical settings in multiple disciplines, including materials science, engineering, chemistry, biology, and medicine. Written by leaders in the field, it covers numerous cell surface engineering methods along with their current and potential applications in cell therapy, tissue engineering, biosensing, and diagnosis. The interface of chemistry, materials science, and biology presents many opportunities for developing innovative tools to diagnose and treat various diseases. However, cell surface engineering using chemistry and materials science approaches is a new and diverse field. This book provides a full coverage of the subject, introducing the fundamentals of cell membrane biology before exploring the key application areas. Demystifies the direct engineering of cell surfaces, enabling materials scientists and chemists to manipulate or augment cell functions and phenotypes Provides a toolkit of micro- and nanoengineering approaches to the manipulation of the cell surface Unlocks the potential of cell surface manipulation for a range of new applications in the fields of in vitro research, cell therapy, tissue engineering, biosensing, and diagnostics

Micro- and Nanoengineering of the Cell Surface explores the direct engineering of cell surfaces, enabling materials scientists and chemists to manipulate or augment cell functions and phenotypes. The book is accessible for readers across industry, academia, and in clinical settings in multiple disciplines, including materials science, engineering, chemistry, biology, and medicine. Written by leaders in the field, it covers numerous cell surface engineering methods along with their current and potential applications in cell therapy, tissue engineering, biosensing, and diagnosis. The interface of chemistry, materials science, and biology presents many opportunities for developing innovative tools to diagnose and treat various diseases. However, cell surface engineering using chemistry and materials science approaches is a new and diverse field. This book provides a full coverage of the subject, introducing the fundamentals of cell membrane biology before exploring the key application areas. Demystifies the direct engineering of cell surfaces, enabling materials scientists and chemists to manipulate or augment cell functions and phenotypes Provides a toolkit of micro- and nanoengineering approaches to the manipulation of the cell surface Unlocks the potential of cell surface manipulation for a range of new applications in the fields of in vitro research, cell therapy, tissue engineering, biosensing, and diagnostics

Supported with 140 illustrations, the volume exhaustively covers the micro- and nano-system technologies involved in developing cell-based bioengineering applications. You get full details on efforts to engineer the soluble and insoluble cell microenvironments, including the latest advances in microfluidic devices, surface patterning, 3D scaffolds, and techniques for engineering cellular mechanical properties and topography.

Fuel cells are clean and efficient energy conversion devices expected to be the next generation power source. During more than 17 decades of research and development, various types of fuel cells have been developed with a view to meet the different energy demands and application requirements. Scientists have devoted a great deal of time and effort

The Handbook of Silicon Based MEMS Materials and Technologies, Second Edition, is a comprehensive guide to MEMS materials, technologies, and manufacturing that examines the state-of-the-art with a particular emphasis on silicon as the most important starting material used in MEMS. The book explains the fundamentals, properties (mechanical, electrostatic, optical, etc.), materials selection, preparation, manufacturing, processing, system integration, measurement, and materials characterization techniques, sensors, and multi-scale modeling methods of MEMS structures, silicon crystals, and wafers, also covering micromachining technologies in MEMS and encapsulation of MEMS components. Furthermore, it provides vital packaging technologies and process knowledge for silicon direct bonding, anodic bonding, glass frit bonding, and related techniques, shows how to protect devices from the environment, and provides tactics to decrease package size for a dramatic reduction in costs. Provides vital packaging technologies and process knowledge for silicon direct bonding, anodic bonding, glass frit bonding, and related techniques Shows how to protect devices from the environment and decrease package size for a dramatic reduction in packaging costs Discusses properties, preparation, and growth of silicon crystals and wafers Explains the many properties (mechanical, electrostatic, optical, etc.), manufacturing, processing, measuring (including focused beam techniques), and multiscale modeling methods of MEMS structures Geared towards practical applications rather than theory

This text book will bring together a mix of both internationally known and established senior scientists along side up and coming (but already accomplished) junior scientists that have varying expertise in fundamental and applied nanotechnology to biology and medicine.

The book outlines first the importance of Extra Cellular Matrix (ECM), which is a natural surface for most of cells. In the following chapters the influence of biological, chemical, mechanical, and physical properties of surfaces in micro and nano-scale on stem cell behavior are discussed including the mechanotransduction. Biomimetic and bioinspired approaches are highlighted for developing microenvironment of several tissues, and surface engineering applications are discussed in tissue engineering, regenerative medicine and different type of biomaterials in various chapters of the book. This book brings together innovative methodologies and strategies adopted in the research and development of Advanced Surfaces in Stem Cell Research. Well-known worldwide researchers deliberate subjects including: Extracellular matrix proteins for stem cell fate The superficial mechanical and physical properties of matrix microenvironment as stem cell fate regulator Effects of mechanotransduction on stem cell behavior Modulation of stem cells behavior through bioactive surfaces Influence of controlled micro and nanoengineered surfaces on stem cell fate Nanostructured polymeric surfaces for stem cells Laser surface modification techniques and stem cells applications Plasma polymer deposition: a versatile tool for stem cell research Application of bioreactor concept and modeling techniques in bone regeneration and augmentation treatments Substrates and surfaces for control of pluripotent stem cell fate and function Application of biopolymer-based, surface modified devices in transplant medicine and tissue engineering Silk as a natural biopolymer for tissue engineering

Stem Cell Nanoengineering reviews the applications of nanotechnology in the fields of stem cells, tissue engineering, and regenerative medicine. Topics addressed include various types of stem cells, underlying principles of nanobiotechnology, the making of nano-scaffolds, nano tissue engineering, applications of nanotechnology in stem cell tracking and molecular imaging, nano-devices, as well as stem cell nano-engineering from bench to bedside. Written by renowned experts in their respective fields, chapters describe and explore a wide variety of topics in stem cell nanoengineering, making the book a valuable resource for both researchers and clinicians in biomedical and bioengineering fields.

Advances in Stem Cell Research discusses recent advances in stem cell science, including therapeutic applications. This volume covers such topics as biomanufacturing iPS cells for therapeutic applications, techniques for controlling stem cell fate decisions, as well as current basic research in such areas as germ line stem cells, genomics and proteomics in stem cell research. It is a useful book for biology and clinical scientists, especially young investigators and stem cell biology students who are newly entering the world of stem cells research. The editors hope that the new knowledge and research outlined in this book will help contribute to new therapies for a wide variety of diseases that presently afflict humanity.

Nano and Micro Engineered Membrane Technology is about Nano and micro engineered membrane technology, an emerging new technological area in membrane technology. Potential applications cover a broad spectrum of science, such as micro and nano filtration, gas separation, optics and nanophotonics, catalysis, microbiology, controlled drug delivery, nanopatterning, micro contact printing, atomisation, cross flow emulsification, etc. A brief overview of filtration membranes and pore structures is presented in chapter 1 and in the subsequent chapter 2 an overview is presented of conventional micro perforation methods, like laser drilling, electroforming, precision etching etc. With micro engineering techniques (chapter 3), originating from the semiconductor industry, it is relatively easy to downscale and form submicron pores (down to 100 nm) using photolithographic methods, with e.g. contact masks and wafer steppers. In chapter 4 some elementary fluid mechanics related to fluid flow in conducts and single and multiple orifices is presented covering analytical methods as well as computational fluid dynamics. Much effort has been put in strength and maximum pressure load analysis (chapter 5) of perforated and unperforated membranes. New analytical expressions were obtained that were verified by a number of computer simulations and many experiments. A separate chapter (chapter 6) has been devoted to the pioneering work of manufacturing polymeric perforated membranes because of its potential future economical impact. Large scale microfiltration applications on e.g. skim milk and lager beer are presented in chapter 7, whereas in chapter 8 a micro scale Lab-on-a-Chip microfiltration/fractionation demonstrator is discussed. Nanotechnology and nano engineered membranes is the fascinating topic of chapter 9, with typical examples as nanopatterning, nanophotonics and nanomembrane technology. This book closes with novel pioneering applications on atomization (chapter 10) for deep pulmonary inhale and cross flow emulsification (chapter 11) for the manufacturing of e.g. functional foods and nano/micro emulsions. Overview on the implementation of nano and micro engineering techniques in membrane science; which is an upcoming new cross-road technology Demonstration of feasibility with respect to micro and nano filtration, gas separation, photonic structures, catalysis, microbiology, controlled drug delivery, nanopatterning, micro contact printing, atomisation and emulsification techniques Informative introductions with rules of thumb for fluid flow in micro channels, pressure strength of thin supported perforated and unperforated membranes, silicon micro machining techniques, membrane filtration technology, Rayleigh breakup and cross-flow emulsification

This volume collects selected papers presented and discussed during the 9th National Conference organized by the Italian Association of Materials Engineering, AIMAT from 2008 at Piano di Sorrento (Napoli, Italy). It gives a valuable representation of highlights of the research and development activities running in 21 Italian universities and research centers in the field of materials science and engineering. All the reported research topics are focused on a methodological approach that takes into account scientific issues and engineering aspects related to real applications.

NanoScience in Biomedicine provides up-to-date information in the frontier fields of nano biomedicine focusing on basic concepts and recent developments in many topical areas including particular nanomaterials synthesis, field emission of carbon nanotubes, flexible dye-sensitized nano-porous films, magnetic nanofluids, and intrinsically electroconducting nanoparticles. Novel methods of synthesizing nanoscale biomaterials and their applications in biomedicine are also included such as nano-sized materials for drug delivery, bioactive molecules for regenerative medicine, nanoscale mechanisms for assembly of biomaterials, and nanostructured materials constructed from polypeptides. This book is organized in three parts: Part I introduces most recent developments in all aspects of design, synthesis, properties, and applications of nanoscale biomaterials. Part II focuses on novel nanotechnologies in biomedicine. Part III includes some of the new developments of nanomaterials’ synthesis and recent studies on nanostructure-properties relationships. The book comprehensively addresses the most critical issues in a tutorial manner so that technical non-specialists and students in both biomedical sciences and engineering will be able to benefit. All chapters are contributed by internationally recognized scholars. Dr. Donglu Shi is a professor at the Chemical and Materials Engineering Department, University of Cincinnati, USA.

Fourth volume of a 40volume series on nano science and nanotechnology, edited by the renowned scientist Challa S.S.R. Kumar. This handbook gives a comprehensive overview about Surface Science Tools for Nanomaterials Characterization. Modern applications and state-of-the-art techniques are covered and make this volume an essential reading for research scientists in academia and industry.

Regenerative medicine focuses on using stem cell biology to advance medical therapies for devastating disorders. Musculoskeletal degeneration and complications from injuries have become more prevalent as people live longer and increasingly participate in rigorous athletic and recreational activities. Additionally, defects in skeletal tissues may immobilize people and cause inflammation and pain. Musculoskeletal regeneration research provides solutions to repair, restore or replace skeletal elements and associated tissues that are affected by acute injury, chronic degeneration, genetic dysfunction and cancer-related defects. The goal of musculoskeletal regeneration medicine research is to improve quality of life and outcomes for people with musculoskeletal injury or degradation. Nanoengineering in Musculoskeletal Regeneration provides the reader an updated summary of therapeutic pipeline from biomedical discovery to clinical implementation, improving treatments for patients with conditions of the muscles, tendons, cartilage, meniscus and bone. This text presents novel, significant, and interdisciplinary theoretical and experimental results related to nanoscience and nanotechnology in the musculoskeletal regeneration. Content includes basic, translational, and clinical research addressing musculoskeletal repair and regeneration for the treatment of diseases and injuries of the skeleton and its associated tissues.