Mineralized Collagen Bone Graft Substitutes

Mineralized Collagen Bone Graft Substitutes
Author: Xiu-Mei Wang,Zhi-Ye Qiu,Helen Cui
Publsiher: Woodhead Publishing
Total Pages: 258
Release: 2019-04-18
Genre: Medical
ISBN: 9780081027394

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Mineralized Collagen Bone Graft Substitutes presents a comprehensive study of biomimetic mineralized collagen, synthesized in vitro, a next generation biomaterial for bone regeneration. By focusing both on fundamental research and the clinical use of this novel material, the book provides a complete examination, from bench to bedside. Chapters discuss natural bone and familiar biomaterials for bone repair, the preparation and safety of mineralized collagen, products made of mineralized collagen, and present clinical case studies. This book is an invaluable and unique resource for researchers, clinicians, students and industrialists in the area of orthopedics and dentistry. Provides a deep analysis of synthetic collagen, from bench to bedside Systematically examines the structure, principles, properties, biomimetic synthesis and characterization of mineralized collagen for bone repair Includes case studies that look at a range of clinical bone repair applications of Mineralized collagen and their clinical results

Bone Graft Substitutes

Bone Graft Substitutes
Author: American Academy of Orthopaedic Surgeons
Publsiher: ASTM International
Total Pages: 315
Release: 2003-01-01
Genre: Medical
ISBN: 0803133561

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Seventeen contributions from leading researchers explore clinical and scientific aspects of bone grafting with an emphasis on new bone graft substitutes entering the marketplace. A sampling of topics includes safety issues in allograft tissue banking, regulatory issues in cell- based therapies, and

Rational Design and Characterization of Innovative Multifunctional Biomimetic Materials

Rational Design and Characterization of Innovative Multifunctional Biomimetic Materials
Author: Lia Rimondini,Lorenzo Moroni,Andrea Cochis
Publsiher: Frontiers Media SA
Total Pages: 135
Release: 2021-04-13
Genre: Technology & Engineering
ISBN: 9782889666874

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Bioinspired and Biomimetic Materials for Drug Delivery

Bioinspired and Biomimetic Materials for Drug Delivery
Author: Md Nurunnabi
Publsiher: Woodhead Publishing
Total Pages: 336
Release: 2021-07-30
Genre: Technology & Engineering
ISBN: 9780128219492

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Bioinspired and Biomimetic Materials for Drug Delivery delves into the potential of bioinspired materials in drug delivery, detailing each material type and its latest developments. In the last decade, biomimetic and bioinspired materials and technology has garnered increased attention in drug delivery research. Various material types including polymer, small molecular, protein, peptide, cholesterol, polysaccharide, nano-crystal and hybrid materials are widely considered in drug delivery research. However, biomimetic and bioinspired materials and technology have shown promising results for use in therapeutics, due to their high biocompatibility and reduced immunogenicity. Such materials include dopamine, extracellular exosome, bile acids, ionic liquids, and red blood cell. This book covers each of these materials in detail, reviewing their potential and usage in drug delivery. As such, this book will be a great source of information for biomaterials scientists, biomedical engineers and those working in pharmaceutical research. Explores latest developments for a broad range of bioinspired and biomimetic materials for drug delivery applications Helps researchers overcome the challenges of biocompatibility and immunogenicity in drug development Provides both theoretical and practical knowledge in regards to materials characterization and use in a range of drugs

Ceramic Materials Mimicking Normal Bone Surface Microstructure and Chemistry Modulate Osteoblast Response

Ceramic Materials Mimicking Normal Bone Surface Microstructure and Chemistry Modulate Osteoblast Response
Author: Brandy Rogers Adams
Publsiher: Unknown
Total Pages: 135
Release: 2013
Genre: Biomedical materials
ISBN: OCLC:880943248

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Bone consists of collagen/hydroxyapatite (HA) composites in which poorly crystalline carbonated calcium phosphate is intercalated within the fibrillar structure. Normal bone mineral is a carbonated-apatite, but there are limited data on the effect of mineral containing carbonate on cell response. Although the exact biological role of silicate in bone formation is unclear, silicate has been identified at trace levels in immature bone and is believed to play a metabolic role in new bone formation. To mimic the inorganic and organic composition of bone we have developed a variety of bone graft substitutes. In the present body of research, we characterized the surface composition of human cortical and trabecular bone. When then characterized the surface compositions of the following potential bone substitutes: carbonated hydroxyapatite (CO32-HA), silicated hydroxyapatite (Si-HA), and collagen sponges mineralized with calcium phosphate using the polymer-induced liquid-precursor (PILP) process. In the latter substitutes, the PILP process leads to type I collagen fibrils infiltrated with an amorphous mineral precursor upon which crystallization leads to intrafibrillar HA closely mimicking physiological bone mineral. We then determined the osteoblast-like cell response to each bone substitute to characterize the substrate's effect on osteoblast differentiation. The observations collectively indicate that cells are sensitive to the formatting of the mineral phase of a bone substitute and that this format can be altered to modulate cell behavior.

To Develop a Transplantable Viable Construct for the Patching of a Bone Defect

To Develop a Transplantable Viable Construct for the Patching of a Bone Defect
Author: Kwok-Ming Chan,陳國明
Publsiher: Open Dissertation Press
Total Pages: 135
Release: 2017-01-26
Genre: Electronic Book
ISBN: 1361318546

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This dissertation, "To Develop a Transplantable Viable Construct for the Patching of a Bone Defect: a New Bone Graft Substitute by Means of Tissue Engineering" by Kwok-ming, Chan, 陳國明, was obtained from The University of Hong Kong (Pokfulam, Hong Kong) and is being sold pursuant to Creative Commons: Attribution 3.0 Hong Kong License. The content of this dissertation has not been altered in any way. We have altered the formatting in order to facilitate the ease of printing and reading of the dissertation. All rights not granted by the above license are retained by the author. Abstract: Bone grafting is an integral part of reconstructive surgery. In the United States alone over 250,000 bone grafts were harvested annually. While autogenic bone grafting has always been associated with donor site morbidity, bone graft substitutes have been suggested as a solution. In this project, a bone graft substitute using human dental pulp cells (HDPCs) and peptide nanofibre hydrogel was being developed. HDPCs were isolated from extracted teeth. After culture and expansion, unsorted HDPCs were encapsulated into peptide nanofibre hydrogel. These cell-gel constructs were cultured for two weeks in ordinary culture medium and then for 2-3 more weeks in osteogenic lineage induction medium. The post-induced cell-gel derived constructs were transplanted into skin pouches or calvarial bone defects of nude mice. When transplanted subcutaneously, the cell-gel derived constructs were harvested at four to twelve weeks postoperatively (n=5). Tissue samples were processed for contact radiograph, histological examination and antibody staining. These constructs developed into vascularised, mineralised tissue pieces. Though bone marker proteins (osteopontin, osteocalcin and osteonectin) were detected in these tissue pieces, the histological structure of their tissue matrix did not resemble bone matrix. Later, it was accidentally noted that portions of constructs touching the bone defect margin, would form bone through direct matrix transformation. This indicated that the current cell-gel model was potentially the first study model of tissue engineering bone by simulating intramembranous ossification. In the bone defect trial, obviously mineralized cell-gel derived constructs of matching shape and size were selected to patch the 3mm calvarial bone defects (n=5). Bone defect specimens were harvested at two weeks post-operation. The development of radio-opaque structures within the bone defects were evaluated in virtual 3-dimensional models constructed with data collected by microtomographic scanning. The bone nature of these radio-opaque structure were validated histologically (by staining with Hematoxylin and Eosin, Periodic acid-Schiff stain and Picrosirius red) and immunologically (with antibody against human collagen-I, osteonectin and parathyroid hormone receptor). The radio-opaque structures developed into the bone defect were evaluated positive for bone. And significantly more bone regeneration was observed in the test group (n=4) than in the control (n=2). The mean area percentages of regeneration were 46.3% and 0% respectively (pWhile the majority of studies in bone tissue engineering have worked with bone marrow stromal cells and scaffolds of synthetic polymer or calcium based materials, this is the first successful attempt of using HDPCs and peptide nanofibre hydrogel to engineer bone (in a nude mice mode). And the potential of these cell-gel derived constructs to promote bone regeneration was demonstrated. But this was the result from a single experiment of small sample size in one animal model only. It needs to be fortified by further experiments with larger population size and in other animal models. To increase clinical usefulness, the construct will need to be scaled up to centimetre size level. This will necessitate a change of its configuration from bead into meshw

Bone Tissue Engineering

Bone Tissue Engineering
Author: Jeffrey O. Hollinger,Thomas A. Einhorn,Bruce Doll,Charles Sfeir
Publsiher: CRC Press
Total Pages: 352
Release: 2004-10-14
Genre: Medical
ISBN: 9781135501914

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Focusing on bone biology, Bone Tissue Engineering integrates basic sciences with tissue engineering. It includes contributions from world-renowned researchers and clinicians who discuss key topics such as different models and approaches to bone tissue engineering, as well as exciting clinical applications for patients. Divided into four sections, t

Current Concepts in Dental Implantology

Current Concepts in Dental Implantology
Author: Ilser Turkyilmaz
Publsiher: BoD – Books on Demand
Total Pages: 276
Release: 2015-02-25
Genre: Medical
ISBN: 9789535117414

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Implant dentistry has changed and enhanced significantly since the introduction of osseointegration concept with dental implants. Because the benefits of therapy became apparent, implant treatment earned a widespread acceptance. Therefore, the need for dental implants has caused a rapid expansion of the market worldwide. Dental implantology continues to excel with the developments of new surgical and prosthodontic techniques, and armamentarium. The purpose of this book named Current Concepts in Dental Implantology is to present a novel resource for dentists who want to replace missing teeth with dental implants. It is a carefully organized book, which blends basic science, clinical experience, and current and future concepts. This book includes ten chapters and our aim is to provide a valuable source for dental students, post-graduate residents and clinicians who want to know more about dental implants.

Comprehensive Biomaterials

Comprehensive Biomaterials
Author: Paul Ducheyne,Kevin Healy,Dietmar W. Hutmacher,David W. Grainger,C. James Kirkpatrick
Publsiher: Elsevier
Total Pages: 3672
Release: 2015-08-28
Genre: Technology & Engineering
ISBN: 9780080552941

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Comprehensive Biomaterials brings together the myriad facets of biomaterials into one, major series of six edited volumes that would cover the field of biomaterials in a major, extensive fashion: Volume 1: Metallic, Ceramic and Polymeric Biomaterials Volume 2: Biologically Inspired and Biomolecular Materials Volume 3: Methods of Analysis Volume 4: Biocompatibility, Surface Engineering, and Delivery Of Drugs, Genes and Other Molecules Volume 5: Tissue and Organ Engineering Volume 6: Biomaterials and Clinical Use Experts from around the world in hundreds of related biomaterials areas have contributed to this publication, resulting in a continuum of rich information appropriate for many audiences. The work addresses the current status of nearly all biomaterials in the field, their strengths and weaknesses, their future prospects, appropriate analytical methods and testing, device applications and performance, emerging candidate materials as competitors and disruptive technologies, and strategic insights for those entering and operational in diverse biomaterials applications, research and development, regulatory management, and commercial aspects. From the outset, the goal was to review materials in the context of medical devices and tissue properties, biocompatibility and surface analysis, tissue engineering and controlled release. It was also the intent both, to focus on material properties from the perspectives of therapeutic and diagnostic use, and to address questions relevant to state-of-the-art research endeavors. Reviews the current status of nearly all biomaterials in the field by analyzing their strengths and weaknesses, performance as well as future prospects Presents appropriate analytical methods and testing procedures in addition to potential device applications Provides strategic insights for those working on diverse application areas such as R&D, regulatory management, and commercial development

Bone Tissue Engineering

Bone Tissue Engineering
Author: Fernando P. S. Guastaldi
Publsiher: Springer Nature
Total Pages: 135
Release: 2022
Genre: Electronic Book
ISBN: 9783030920142

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Biodegradable Polymers in Clinical Use and Clinical Development

Biodegradable Polymers in Clinical Use and Clinical Development
Author: Abraham J. Domb,Neeraj Kumar
Publsiher: John Wiley & Sons
Total Pages: 752
Release: 2011-05-12
Genre: Technology & Engineering
ISBN: 1118015800

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This book focuses on biodegradable polymers that are already in clinical use or under clinical development. Synthetic and natural polymers will be included. This excludes polymers that have been investigated and did not reach clinical development. The purpose of this book is to provide updated status of the polymers that are clinical use and those that are now being developed for clinical use and hopefully will reach the clinic during the next 5 years. The book provides information that of interest to academics and practicing researchers including chemists, biologists and bioengineers and users: physicians, pharmacists.

Biomimetics

Biomimetics
Author: Murugan Ramalingam,Xiumei Wang,Guoping Chen,Peter Ma,Fu-Zhai Cui
Publsiher: John Wiley & Sons
Total Pages: 384
Release: 2013-08-01
Genre: Science
ISBN: 9781118810392

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This book compiles all aspects of biomimetics from fundamentalprinciples to current technological advances and their futuretrends in the development of nanoscale biomaterials and tissueengineering. The scope of this book is principally confined tobiologically-inspired design of materials and systems for thedevelopment of next generation nanobiomaterials and tissueengineering. The book addresses the state-of-the-art of researchprogress in the applications of the principles, processes, andtechniques of biomimetics. The prospective outcomes of currentadvancements and challenges in biomimetic approaches are alsopresented.

Biomineralization

Biomineralization
Author: Erich Konigsberger,LanChi Konigsberger
Publsiher: John Wiley & Sons
Total Pages: 302
Release: 2006-07-11
Genre: Science
ISBN: 9780470092118

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This title takes an interdisciplinary approach to the central role of solubility in pathological biomineralisation, ranging from traditional thermodynamics and kinetics to unusual concepts such as the PILP process. The scientific background and expertise of the contributors, ranges accordingly from solubility modelling and database development, renal stone and bone implant research, Mössbauer spectroscopy and structural chemistry to biochemistry and crystallisation. The chapters all have a quantitative, physico-chemical component rather than giving purely phenomenological descriptions. The contributors deal with aspects and concepts that have not previously been common in the study of pathological biomineralisation processes.

Biomaterials for Organ and Tissue Regeneration

Biomaterials for Organ and Tissue Regeneration
Author: Nihal Vrana,Helena Knopf-Marques,Julien Barthes
Publsiher: Woodhead Publishing
Total Pages: 846
Release: 2020-03-20
Genre: Medical
ISBN: 9780081029077

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Biomaterials for Organ and Tissue Regeneration: New Technologies and Future Prospects examines the use of biomaterials in applications related to artificial tissues and organs. With a strong focus on fundamental and traditional tissue engineering strategies, the book also examines how emerging and enabling technologies are being developed and applied. Sections provide essential information on biomaterial, cell properties and cell types used in organ generation. A section on state-of-the-art in organ regeneration for clinical purposes is followed by a discussion on enabling technologies, such as bioprinting, on chip organ systems and in silico simulations. Provides a systematic overview of the field, from fundamentals, to current challenges and opportunities Encompasses the classic paradigm of tissue engineering for creation of new functional tissue Discusses enabling technologies such as bioprinting, organ-on-chip systems and in silico simulations

Campbell s Operative Orthopaedics E Book

Campbell s Operative Orthopaedics  E Book
Author: Frederick M Azar,S. Terry Canale,James H. Beaty
Publsiher: Elsevier Health Sciences
Total Pages: 5016
Release: 2020-12-23
Genre: Medical
ISBN: 9780323672191

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Still the most widely used comprehensive resource in orthopaedic surgery, Campbell’s Operative Orthopaedics is an essential reference for trainees, a trusted clinical tool for practitioners, and the gold standard for worldwide orthopaedic practice. Unparalleled in scope and depth, this 14th Edition contains updated diagnostic images, practical guidance on when and how to perform every procedure, and rapid access to data in preparation for surgical cases or patient evaluation. Drs. Frederick M. Azar and James H. Beaty, along with other expert contributors from the world-renowned Campbell Clinic, have collaborated diligently to ensure that this 4-volume text remains a valuable resource in your practice, helping you achieve optimal outcomes with every patient. Features evidence-based surgical coverage throughout to aid in making informed clinical choices for each patient. Covers multiple procedures for all body regions to provide comprehensive coverage. Keeps you up to date with even more high-quality procedural videos, a new chapter on biologics in orthopaedics, and expanded and updated content on hip arthroscopy, patellofemoral arthritis and more. Follows a standard template for every chapter that features highlighted procedural steps, high-quality illustrations for clear visual guidance, and bulleted text. Enhanced eBook version included with purchase. Your enhanced eBook allows you to access all of the text, figures, and references from the book on a variety of devices