Modeling and Control of Infectious Diseases in the Host

Modeling and Control of Infectious Diseases in the Host
Author: Esteban A. Hernandez-Vargas
Publsiher: Academic Press
Total Pages: 220
Release: 2019-02-15
Genre: Technology & Engineering
ISBN: 9780128130520

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Modeling and Control of Infectious Diseases in the Host: With MATLAB and R provides a holistic understanding of health and disease by presenting topics on quantitative decision-making that influence the development of drugs. The book presents modeling advances in different viral infections, dissecting detailed contributions of key players, along with their respective interactions. By combining tailored in vivo experiments and mathematical modeling approaches, the book clarifies the relative contributions of different underlying mechanisms within hosts of the most lethal viral infections, including HIV, influenza and Ebola. Illustrative examples for parameter fitting, modeling and control applications are explained using MATLAB and R. Provides a multi-scale framework to link within-host infection dynamics (individual level) to between-host transmission fitness (epidemiological level) in viral infectious diseases Includes PK/PD modeling and simulation approaches to improve efficiency and decision-making at preclinical development phases Presents a theoretic approach to schedule drug treatments

Modeling and Control of Infectious Diseases in the Host

Modeling and Control of Infectious Diseases in the Host
Author: Esteban A. Hernandez-Vargas
Publsiher: Academic Press
Total Pages: 256
Release: 2019-02-14
Genre: Technology & Engineering
ISBN: 9780128131114

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Modeling and Control of Infectious Diseases in the Host: With MATLAB and R provides a holistic understanding of health and disease by presenting topics on quantitative decision-making that influence the development of drugs. The book presents modeling advances in different viral infections, dissecting detailed contributions of key players, along with their respective interactions. By combining tailored in vivo experiments and mathematical modeling approaches, the book clarifies the relative contributions of different underlying mechanisms within hosts of the most lethal viral infections, including HIV, influenza and Ebola. Illustrative examples for parameter fitting, modeling and control applications are explained using MATLAB and R. Provides a multi-scale framework to link within-host infection dynamics (individual level) to between-host transmission fitness (epidemiological level) in viral infectious diseases Includes PK/PD modeling and simulation approaches to improve efficiency and decision-making at preclinical development phases Presents a theoretic approach to schedule drug treatments

Modeling the Transmission and Prevention of Infectious Disease

Modeling the Transmission and Prevention of Infectious Disease
Author: Christon J. Hurst
Publsiher: Springer
Total Pages: 286
Release: 2017-08-31
Genre: Science
ISBN: 9783319606163

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This volume focuses on blocking disease transmission and the ecological perspective of pathogens and pathogenic processes. The chapters on blocking transmission cover the environmental safety of space flight, biocides and biocide resistance, as well as infection control in healthcare facilities. The book also offers insights into the ecological aspects of infectious disease, introducing the reader to the role of indigenous gut microbiota in maintaining human health and current discussions on environmentally encountered bacterial and fungal pathogens including species that variously cause the necrotizing skin disease Buruli ulcer and coccidioidomycosis. Further, it explores the influenza A virus as an example for understanding zoonosis. It is a valuable resource for microbiologists and biomedical scientists alike.

Modeling Disease Spread and Control

Modeling Disease Spread and Control
Author: Tariq Halasa,Salome Dürr
Publsiher: Frontiers Media SA
Total Pages: 135
Release: 2018-01-18
Genre: Electronic Book
ISBN: 9782889453849

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Mathematical models are useful tools to understand the epidemiology and agent-host interaction of diseases. They are developed and applied since over a century, but with increasing computer capacity, they become increasingly prominent as part of evidence based decision making. Mathematical models are frequently used to construct preparedness and contingency plans for highly contagious diseases such as foot-and-mouth disease. This allows proposing effective strategies to control the spread of the disease in case of an incursion, and avails useful tools to support decision making during an outbreak. They are also used to monitor, prevent and control endemic diseases within populations or farms. In addition, mathematical models improve our understanding of the contact structure between farms, pointing out risky elements in the contact network for disease introduction or further spread within the population. This Research Topic presents valuable studies presenting different aspects and implementations of mathematical modeling for disease spread and control in the veterinary field. The areas covered include model construction, network analysis, tools for decision makers, and costeffective control of endemic diseases.

Modeling Infectious Diseases in Humans and Animals

Modeling Infectious Diseases in Humans and Animals
Author: Matt J. Keeling,Pejman Rohani
Publsiher: Princeton University Press
Total Pages: 408
Release: 2011-09-19
Genre: Science
ISBN: 9781400841035

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For epidemiologists, evolutionary biologists, and health-care professionals, real-time and predictive modeling of infectious disease is of growing importance. This book provides a timely and comprehensive introduction to the modeling of infectious diseases in humans and animals, focusing on recent developments as well as more traditional approaches. Matt Keeling and Pejman Rohani move from modeling with simple differential equations to more recent, complex models, where spatial structure, seasonal "forcing," or stochasticity influence the dynamics, and where computer simulation needs to be used to generate theory. In each of the eight chapters, they deal with a specific modeling approach or set of techniques designed to capture a particular biological factor. They illustrate the methodology used with examples from recent research literature on human and infectious disease modeling, showing how such techniques can be used in practice. Diseases considered include BSE, foot-and-mouth, HIV, measles, rubella, smallpox, and West Nile virus, among others. Particular attention is given throughout the book to the development of practical models, useful both as predictive tools and as a means to understand fundamental epidemiological processes. To emphasize this approach, the last chapter is dedicated to modeling and understanding the control of diseases through vaccination, quarantine, or culling. Comprehensive, practical introduction to infectious disease modeling Builds from simple to complex predictive models Models and methodology fully supported by examples drawn from research literature Practical models aid students' understanding of fundamental epidemiological processes For many of the models presented, the authors provide accompanying programs written in Java, C, Fortran, and MATLAB In-depth treatment of role of modeling in understanding disease control

Modeling the Interplay Between Human Behavior and the Spread of Infectious Diseases

Modeling the Interplay Between Human Behavior and the Spread of Infectious Diseases
Author: Piero Manfredi,Alberto D'Onofrio
Publsiher: Springer Science & Business Media
Total Pages: 329
Release: 2013-01-04
Genre: Mathematics
ISBN: 9781461454748

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This volume summarizes the state-of-the-art in the fast growing research area of modeling the influence of information-driven human behavior on the spread and control of infectious diseases. In particular, it features the two main and inter-related “core” topics: behavioral changes in response to global threats, for example, pandemic influenza, and the pseudo-rational opposition to vaccines. In order to make realistic predictions, modelers need to go beyond classical mathematical epidemiology to take these dynamic effects into account. With contributions from experts in this field, the book fills a void in the literature. It goes beyond classical texts, yet preserves the rationale of many of them by sticking to the underlying biology without compromising on scientific rigor. Epidemiologists, theoretical biologists, biophysicists, applied mathematicians, and PhD students will benefit from this book. However, it is also written for Public Health professionals interested in understanding models, and to advanced undergraduate students, since it only requires a working knowledge of mathematical epidemiology.

Epidemics

Epidemics
Author: Ottar N. Bjørnstad
Publsiher: Springer
Total Pages: 312
Release: 2018-10-30
Genre: Medical
ISBN: 9783319974873

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This book is designed to be a practical study in infectious disease dynamics. The book offers an easy to follow implementation and analysis of mathematical epidemiology. The book focuses on recent case studies in order to explore various conceptual, mathematical, and statistical issues. The dynamics of infectious diseases shows a wide diversity of pattern. Some have locally persistent chains-of-transmission, others persist spatially in ‘consumer-resource metapopulations’. Some infections are prevalent among the young, some among the old and some are age-invariant. Temporally, some diseases have little variation in prevalence, some have predictable seasonal shifts and others exhibit violent epidemics that may be regular or irregular in their timing. Models and ‘models-with-data’ have proved invaluable for understanding and predicting this diversity, and thence help improve intervention and control. Using mathematical models to understand infectious disease dynamics has a very rich history in epidemiology. The field has seen broad expansions of theories as well as a surge in real-life application of mathematics to dynamics and control of infectious disease. The chapters of Epidemics: Models and Data using R have been organized in a reasonably logical way: Chapters 1-10 is a mix and match of models, data and statistics pertaining to local disease dynamics; Chapters 11-13 pertains to spatial and spatiotemporal dynamics; Chapter 14 highlights similarities between the dynamics of infectious disease and parasitoid-host dynamics; Finally, Chapters 15 and 16 overview additional statistical methodology useful in studies of infectious disease dynamics. This book can be used as a guide for working with data, models and ‘models-and-data’ to understand epidemics and infectious disease dynamics in space and time.

Infectious Diseases of Humans

Infectious Diseases of Humans
Author: Roy M. Anderson,Robert M. May
Publsiher: Oxford University Press
Total Pages: 757
Release: 1992-08-27
Genre: Medical
ISBN: 019854040X

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This book deals with infectious diseases -- viral, bacterial, protozoan and helminth -- in terms of the dynamics of their interaction with host populations. The book combines mathematical models with extensive use of epidemiological and other data. This analytic framework is highly useful for the evaluation of public health strategies aimed at controlling or eradicating particular infections. Such a framework is increasingly important in light of the widespread concern for primary health care programs aimed at such diseases as measles, malaria, river blindness, sleeping sickness, and schistosomiasis, and the advent of AIDS/HIV and other emerging viruses. Throughout the book, the mathematics is used as a tool for thinking clearly about fundamental and applied problems having to do with infectious diseases. The book is divided into two parts, one dealing with microparasites (viruses, bacteria and protozoans) and the other with macroparasites (helminths and parasitic arthropods). Each part begins with simple models, developed in a biologically intuitive way, and then goes on to develop more complicated and realistic models as tools for public health planning. The book synthesizes previous work in this rapidly growing field (much of which is scattered between the ecological and the medical literature) with a good deal of new material.

Modelling Parasite Transmission and Control

Modelling Parasite Transmission and Control
Author: Edwin Michael,Robert C. Spear
Publsiher: Springer Science & Business Media
Total Pages: 212
Release: 2010-12-31
Genre: Medical
ISBN: 9781441960641

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It is clear that many fascinating problems still remain to be addressed in parasite transmission modelling, from better understanding of transmission processes and natural history of infection to investigating the impact of ecological and spatial scales, climate change, host immunity and social behaviour, parasite-host evolutionary dynamics and parasite community ecology on parasite transmission. This book captures some of the advances made in recent years and provides indications of ways forward for addressing these questions by shedding light on developments in conceptual frameworks and modelling tools as well as the emergence of new data forms for aiding model construction, testing and analysis. Another important advance has been the parallel development of robust computationally-intensive statistical methods to allow model testing and parameterization by aiding the fitting of models to complex data. This is an exciting area of work, which we believe will broaden the scope of mathematical modelling in investigating parasite transmission processes. In particular, we expect this advance will now allow modellers to begin the successful development and analysis of mechanistically-rich models of parasite transmission that will facilitate better integration of the variety of mechanisms increasingly recognized as important in simultaneously affecting transmission, including abiotic processes, trophic and evolutionary interactions, movement in space, and behaviour and even physiology of the individual. We foresee a continuing bright future for using mathematical modelling to clarify parasite transmission dynamics and address problems related to effective parasite control. Ultimately, through this improved application of models to research and management, we expect that parasite control would be an achievable goal bringing benefits to a vast number of our fellow human beings.

Mathematical Epidemiology

Mathematical Epidemiology
Author: Fred Brauer,Pauline van den Driessche,J. Wu
Publsiher: Springer Science & Business Media
Total Pages: 414
Release: 2008-04-30
Genre: Medical
ISBN: 9783540789109

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Based on lecture notes of two summer schools with a mixed audience from mathematical sciences, epidemiology and public health, this volume offers a comprehensive introduction to basic ideas and techniques in modeling infectious diseases, for the comparison of strategies to plan for an anticipated epidemic or pandemic, and to deal with a disease outbreak in real time. It covers detailed case studies for diseases including pandemic influenza, West Nile virus, and childhood diseases. Models for other diseases including Severe Acute Respiratory Syndrome, fox rabies, and sexually transmitted infections are included as applications. Its chapters are coherent and complementary independent units. In order to accustom students to look at the current literature and to experience different perspectives, no attempt has been made to achieve united writing style or unified notation. Notes on some mathematical background (calculus, matrix algebra, differential equations, and probability) have been prepared and may be downloaded at the web site of the Centre for Disease Modeling (www.cdm.yorku.ca).

Disease Control Priorities Third Edition Volume 6

Disease Control Priorities  Third Edition  Volume 6
Author: Prabhat Jha
Publsiher: Disease Control Priorities
Total Pages: 506
Release: 2017-12-04
Genre: Medical
ISBN: 1464805261

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Infectious diseases are the leading cause of death globally, particularly among children and young adults. The spread of new pathogens and the threat of antimicrobial resistance pose particular challenges in combating these diseases. Major Infectious Diseases identifies feasible, cost-effective packages of interventions and strategies across delivery platforms to prevent and treat HIV/AIDS, other sexually transmitted infections, tuberculosis, malaria, adult febrile illness, viral hepatitis, and neglected tropical diseases. The volume emphasizes the need to effectively address emerging antimicrobial resistance, strengthen health systems, and increase access to care. The attainable goals are to reduce incidence, develop innovative approaches, and optimize existing tools in resource-constrained settings.

Wildlife and Emerging Zoonotic Diseases The Biology Circumstances and Consequences of Cross Species Transmission

Wildlife and Emerging Zoonotic Diseases  The Biology  Circumstances and Consequences of Cross Species Transmission
Author: James E. Childs,John S. Mackenzie,Jürgen A. Richt
Publsiher: Springer Science & Business Media
Total Pages: 524
Release: 2007-07-23
Genre: Medical
ISBN: 9783540709626

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This volume offers an overview of the processes of zoonotic viral emergence, the intricacies of host/virus interactions, and the role of biological transitions and modifying factors. The themes introduced here are amplified and explored in detail by the contributing authors, who explore the mechanisms and unique circumstances by which evolution, biology, history, and current context have contrived to drive the emergence of different zoonotic agents by a series of related events.

Modelling Vector borne and Other Parasitic Diseases

Modelling Vector borne and Other Parasitic Diseases
Author: Hansen, J.W (ed.),Brain D. Perry
Publsiher: ILRI (aka ILCA and ILRAD)
Total Pages: 369
Release: 1994-01-01
Genre: Insects as carriers of disease
ISBN: 9290552972

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Infectious Disease Epidemiology

Infectious Disease Epidemiology
Author: Ibrahim Abubakar,Helen R. Stagg,Ted Cohen,Laura C. Rodrigues
Publsiher: Oxford University Press
Total Pages: 416
Release: 2016-04-07
Genre: Medical
ISBN: 9780191030550

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Infectious Disease Epidemiology is a concise reference guide which provides trainees and practicing epidemiologists with the information that they need to understand the basic concepts necessary for working in this specialist area. Divided into two sections, part one comprehensively covers the basic principles and methods relevant to the study of infectious disease epidemiology. It is organised in order of increasing complexity, ranging from a general introduction to subjects such as mathematical modelling and sero-epidemiology. Part two examines key major infectious diseases that are of global significance. Grouped by their route of transmission for ease of reference, they include diseases that present a particular burden or a high potential for causing mortality. This practical guide will be essential reading for postgraduate students in infectious disease epidemiology, health protection trainees, and practicing epidemiologists.

Microbial Threats to Health

Microbial Threats to Health
Author: Institute of Medicine,Board on Global Health,Committee on Emerging Microbial Threats to Health in the 21st Century
Publsiher: National Academies Press
Total Pages: 397
Release: 2003-08-25
Genre: Medical
ISBN: 0309185548

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Infectious diseases are a global hazard that puts every nation and every person at risk. The recent SARS outbreak is a prime example. Knowing neither geographic nor political borders, often arriving silently and lethally, microbial pathogens constitute a grave threat to the health of humans. Indeed, a majority of countries recently identified the spread of infectious disease as the greatest global problem they confront. Throughout history, humans have struggled to control both the causes and consequences of infectious diseases and we will continue to do so into the foreseeable future. Following up on a high-profile 1992 report from the Institute of Medicine, Microbial Threats to Health examines the current state of knowledge and policy pertaining to emerging and re-emerging infectious diseases from around the globe. It examines the spectrum of microbial threats, factors in disease emergence, and the ultimate capacity of the United States to meet the challenges posed by microbial threats to human health. From the impact of war or technology on disease emergence to the development of enhanced disease surveillance and vaccine strategies, Microbial Threats to Health contains valuable information for researchers, students, health care providers, policymakers, public health officials. and the interested public.