Modern Computational Approaches to Traditional Chinese Medicine

Modern Computational Approaches to Traditional Chinese Medicine
Author: Zhaohui Wu,Huajun Chen,Xiaohong Jiang
Publsiher: Elsevier
Total Pages: 250
Release: 2012-10-22
Genre: Computers
ISBN: 9780123985194

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Recognized as an essential component of Chinese culture, Traditional Chinese Medicine (TCM) is both an ancient medical system and one still used widely in China today. TCM’s independently evolved knowledge system is expressed mainly in the Chinese language and the information is frequently only available through ancient classics and confidential family records, making it difficult to utilize. The major concern in TCM is how to consolidate and integrate the data, enabling efficient retrieval and discovery of novel knowledge from the dispersed data. Computational approaches such as data mining, semantic reasoning and computational intelligence have emerged as innovative approaches for the reservation and utilization of this knowledge system. Typically, this requires an inter-disciplinary approach involving Chinese culture, computer science, modern healthcare and life sciences. This book examines the computerization of TCM information and knowledge to provide intelligent resources and supporting evidences for clinical decision-making, drug discovery, and education. Recent research results from the Traditional Chinese Medicine Informatics Group of Zhejiang University are presented, gathering in one resource systematic approaches for massive data processing in TCM. These include the utilization of modern Semantic Web and data mining methods for more advanced data integration, data analysis and integrative knowledge discovery. This book will appeal to medical professionals, life sciences students, computer scientists, and those interested in integrative, complementary, and alternative medicine. Interdisciplinary book bringing together Traditional Chinese Medicine and computer scientists Introduces novel network technologies to Traditional Chinese Medicine informatics Provides theory and practical examples and case studies of new techniques

Traditional Chinese Medicine

Traditional Chinese Medicine
Author: James D Adams,Eric J Lien
Publsiher: Royal Society of Chemistry
Total Pages: 349
Release: 2015-10-20
Genre: Science
ISBN: 9781782624936

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Traditional Chinese medicine has a strong scientific basis, but the science of these important preparations is often rarely discussed. Western approaches often simplify traditional Chinese medicine to drug discovery in Chinese plants, however, the majority of traditional Chinese medications use complex mixtures of plant extracts, rather than single purified drugs. The combination of different extracts is based on yin, yang and chi theories, which are often poorly understood in the West. Yin and yang are known to be the balance of agonists and antagonists, whereas chi derives from signalling processes in the body and regulates bodily functions. Traditional Chinese medical practitioners understand that yin, yang and chi constantly interact in the body to maintain health. Western medical practitioners understand how to use agonists and antagonists and how to modify signalling processes, but generally do not accept the use of complex plant extracts to perform these functions. Aimed at medical scientists, and including detailed explanations of the theories behind the science, this text may help researchers to understand, and communicate more effectively with, Chinese medical practitioners and will lead to greater acceptance of traditional medications in the West. Presenting a clear rationale for the use of traditional Chinese medications in Western medical facilities, it enables scientists to find new directions in experimental design and encourage examination of these useful, but often poorly understood, preparations in clinical trials.

Recent Advances in Theories and Practice of Chinese Medicine

Recent Advances in Theories and Practice of Chinese Medicine
Author: Haixue Kuang
Publsiher: IntechOpen
Total Pages: 506
Release: 2012-01-18
Genre: Medical
ISBN: 9533079037

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During the recent years, traditional Chinese medicine (TCM) has attracted the attention of researchers all over the world. It is looked upon not only as a bright pearl, but also a treasure house of ancient Chinese culture. Nowadays, TCM has become a subject area with high potential and the possibility for original innovation. This book titled Recent Advances in Theories and Practice of Chinese Medicine provides an authoritative and cutting-edge insight into TCM research, including its basic theories, diagnostic approach, current clinical applications, latest advances, and more. It discusses many often neglected important issues, such as the theory of TCM property, and how to carry out TCM research in the direction of TCM property theory using modern scientific technology. The authors of this book comprise an international group of recognized researchers who possess abundant clinical knowledge and research background due to their years of practicing TCM. Hopefully, this book will help our readers gain a deeper understanding of the unique characteristics of Chinese medicine.

Recent Advances in Theories and Practice of Chinese Medicine

Recent Advances in Theories and Practice of Chinese Medicine
Author: Haixue Kuang
Publsiher: IntechOpen
Total Pages: 506
Release: 2012-01-18
Genre: Medical
ISBN: 9533079037

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During the recent years, traditional Chinese medicine (TCM) has attracted the attention of researchers all over the world. It is looked upon not only as a bright pearl, but also a treasure house of ancient Chinese culture. Nowadays, TCM has become a subject area with high potential and the possibility for original innovation. This book titled Recent Advances in Theories and Practice of Chinese Medicine provides an authoritative and cutting-edge insight into TCM research, including its basic theories, diagnostic approach, current clinical applications, latest advances, and more. It discusses many often neglected important issues, such as the theory of TCM property, and how to carry out TCM research in the direction of TCM property theory using modern scientific technology. The authors of this book comprise an international group of recognized researchers who possess abundant clinical knowledge and research background due to their years of practicing TCM. Hopefully, this book will help our readers gain a deeper understanding of the unique characteristics of Chinese medicine.

Computational Toxicology

Computational Toxicology
Author: Sean Ekins
Publsiher: John Wiley & Sons
Total Pages: 432
Release: 2018-01-15
Genre: Science
ISBN: 9781119282587

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A key resource for toxicologists across a broad spectrum of fields, this book offers a comprehensive analysis of molecular modelling approaches and strategies applied to risk assessment for pharmaceutical and environmental chemicals. • Provides a perspective of what is currently achievable with computational toxicology and a view to future developments • Helps readers overcome questions of data sources, curation, treatment, and how to model / interpret critical endpoints that support 21st century hazard assessment • Assembles cutting-edge concepts and leading authors into a unique and powerful single-source reference • Includes in-depth looks at QSAR models, physicochemical drug properties, structure-based drug targeting, chemical mixture assessments, and environmental modeling • Features coverage about consumer product safety assessment and chemical defense along with chapters on open source toxicology and big data

Traditional Chinese Medicines Molecular Structures Natural Sources and Applications

Traditional Chinese Medicines  Molecular Structures  Natural Sources and Applications
Author: Xinjian Yan,Guirong Xie,Jiaju Zhou,G. W. A. Milne
Publsiher: Routledge
Total Pages: 1396
Release: 2018-10-03
Genre: Social Science
ISBN: 9781351758093

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This title was first published in 2003. In laboratories around the world the active principles in traditional herbal medicines are being isolated and characterized. A systematic effort at the Chinese Academy of Sciences is underway to identify the structure-activity relationships that result from the link between chemistry and medicine that is permitted by this data. This book, which provides the only systematic English-language description of the chemical structures and pharmacological effects of compounds active in traditional Chinese medicines (TCMs), is now in its second edition. The new edition provides English-language monographs on over 9000 chemicals isolated from nearly 4000 natural sources used in Chinese medicine and features the addition of in-depth bioactivity data for many of the compounds. Effects and indications of the medicines are included. Extensive indexing permits cross-referencing among English, Chinese and Latin names for natural medicinal sources, effects and indications, and the chemical components of the medicines. The second edition of Traditional Chinese Medicines includes 2300 new compounds, 2400 additional plant sources, more CAS Registry Numbers, and more pharmacological data. The structure of the book has been extensively reorganised to make cross referencing the data much simpler. This new edition is therefore a substantial improvement on the first edition of this important reference on the structural chemistry of traditional Chinese medicines.

Network Pharmacology

Network Pharmacology
Author: Shao Li
Publsiher: Springer Nature
Total Pages: 135
Release: 2022
Genre: Electronic Book
ISBN: 9789811607530

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Using a Computational Approach to Study the History of Systems Biology

Using a Computational Approach to Study the History of Systems Biology
Author: Yawen Zou
Publsiher: Unknown
Total Pages: 209
Release: 2016
Genre: Electronic dissertations
ISBN: OCLC:962306282

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Systems biology studies complex biological systems. It is an interdisciplinary field, with biologists working with non-biologists such as computer scientists, engineers, chemists, and mathematicians to address research problems applying systems perspectives. How these different researchers and their disciplines differently contributed to the advancement of this field over time is a question worth examining. Did systems biology become a systems-oriented science or a biology-oriented science from 1992 to 2013?This project utilized computational tools to analyze large data sets and interpreted the results from historical and philosophical perspectives. Tools deployed were derived from scientometrics, corpus linguistics, text-based analysis, network analysis, and GIS analysis to analyze more than 9000 articles (metadata and text) on systems biology. The application of these tools to a HPS project represents a novel approach.The dissertation shows that systems biology has transitioned from a more mathematical, computational, and engineering-oriented discipline focusing on modeling to a more biology-oriented discipline that uses modeling as a means to address real biological problems. Also, the results show that bioengineering and medical research has increased within systems biology. This is reflected in the increase of the centrality of biology-related concepts such as cancer, over time. The dissertation also compares the development of systems biology in China with some other parts of the world, and reveals regional differences, such as a unique trajectory of systems biology in China related to a focus on traditional Chinese medicine. This dissertation adds to the historiography of modern biology where few studies have focused on systems biology compared with the history of molecular biology and evolutionary biology.

Know Your Remedies

Know Your Remedies
Author: He Bian
Publsiher: Princeton University Press
Total Pages: 264
Release: 2022-03-08
Genre: History
ISBN: 9780691200132

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A cultural history of the concept of pharmacy, both the material nature of drugs and the trade in medicine, in early modern China Know Your Remedies presents a panoramic inquiry into China’s early modern cultural transformation through the lens of pharmacy. In the history of science and civilization in China, pharmacy—as a commercial enterprise and as a branch of classical medicine—resists easy characterization. While China’s long tradition of documenting the natural world through state-commissioned pharmacopeias, known as bencao, dwindled after the sixteenth century, the ubiquitous presence of Chinese pharmacy shops around the world today testifies to the vitality of Traditional Chinese Medicine. Rejecting narratives of intellectual stagnation or an unchanging folk culture, He Bian argues that pharmacy’s history in early modern China can best be understood as a dynamic interplay between elite and popular culture. Beginning with decentralizing trends in book culture and fiscal policy in the sixteenth century, Bian reveals pharmacy’s central role in late Ming public discourse. Fueled by factional politics in the early 1600s, amateur investigation into pharmacology reached peak popularity among the literati on the eve of the Qing conquest in the mid-seventeenth century. The eighteenth century witnessed a systematic reclassification of knowledge, as the Qing court turned away from pharmacopeia in favor of a demedicalized natural history. Throughout this time, growth in long-distance trade enabled the rise of urban pharmacy shops, generating new knowledge about the natural world. Bringing together a wealth of primary sources, Know Your Remedies makes an essential contribution to the study of Chinese history and the history of medicine.

Calendar

Calendar
Author: Chinese University of Hong Kong
Publsiher: Unknown
Total Pages: 135
Release: 2004
Genre: Electronic Book
ISBN: IND:30000088099985

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The Encyclopedia of Chinese Medicine

The Encyclopedia of Chinese Medicine
Author: Duo Gao
Publsiher: Unknown
Total Pages: 208
Release: 2000
Genre: Acupuncture
ISBN: 1842221833

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White hots.

Approaching Complex Diseases

Approaching Complex Diseases
Author: Mariano Bizzarri
Publsiher: Springer Nature
Total Pages: 483
Release: 2020-04-17
Genre: Medical
ISBN: 9783030328573

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This volume – for pharmacologists, systems biologists, philosophers and historians of medicine – points to investigate new avenues in pharmacology research, by providing a full assessment of the premises underlying a radical shift in the pharmacology paradigm. The pharmaceutical industry is currently facing unparalleled challenges in developing innovative drugs. While drug-developing scientists in the 1990s mostly welcomed the transformation into a target-based approach, two decades of experience shows that this model is failing to boost both drug discovery and efficiency. Selected targets were often not druggable and with poor disease linkage, leading to either high toxicity or poor efficacy. Therefore, a profound rethinking of the current paradigm is needed. Advances in systems biology are revealing a phenotypic robustness and a network structure that strongly suggest that exquisitely selective compounds, compared with multitarget drugs, may exhibit lower than desired clinical efficacy. This appreciation of the role of polypharmacology has significant implications for tackling the two major sources of attrition in drug development, efficacy and toxicity. Integrating network biology and polypharmacology holds the promise of expanding the current opportunity space for druggable targets.

Chinmedomics

Chinmedomics
Author: Xijun Wang,Aihua Zhang,Hui Sun
Publsiher: Academic Press
Total Pages: 408
Release: 2015-07-15
Genre: Medical
ISBN: 9780128031186

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Chinmedomics: The Integration of Serum Pharmacochemistry and Metabolomics to Elucidate the Scientific Value of Traditional Chinese Medicine uses new experimental techniques and research to open doors in drug discovery and development related to traditional Chinese medicine (TCM). This book features a unique approach that combines chemometric analysis with metabolomics studies to illuminate significant changes that have occurred in syndrome states while simultaneously analyzing the efficacy of chemical ingredients in herbal medicines. Chapters provide cutting-edge information on traditional medicine, analytical technology, natural products, metabolomics, bioinformatics and their applications. This book provides a valuable resource for pharmacologists, pharmaceutical scientists, medicinal plant researchers, pharmacognosists and chemists working with TCM and highlights ways to further research and advances in this area in the future. Presents a practical guide for new practitioners of Chinmedomics with insights on the current use and future development of this method Each chapter includes an introduction, method, references to the latest literature, possible mechanisms of action and applications Edited by the leading experts of research related to Chinmedomics

Systems Biology for Traditional Chinese Medicine

Systems Biology for Traditional Chinese Medicine
Author: Guoan Luo,Yiming Wang,Qionglin Liang,Qingfei Liu
Publsiher: John Wiley & Sons
Total Pages: 400
Release: 2012-05-11
Genre: Science
ISBN: 9781118313350

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The application of systems biology methods to TraditionalChinese Medicine Emphasizing the harmony of the human body with the environment,Traditional Chinese Medicine (TCM) has evolved over thousands ofyears. It is a systemic theory derived from clinical experience,the philosophy of holism and systematology, and the belief that manis an integral part of nature. Systems Biology for Traditional Chinese Medicinedescribes how the latest methods in systems biology can be appliedto TCM, providing a comprehensive resource for the modernizationand advancement of TCM as well as general drug discovery efforts.It is the first comprehensive work to propose a system-to-systemresearch methodology to study the interaction between TCM and thehuman body and its applications in drug research anddevelopment. Using three popular traditional Chinesemedicines—Shuanglongfang, Qingkailing, andLiushenwan—as examples, the authors set forth case examplesdemonstrating how to find material groups, perform efficacyscreenings, and conduct safety evaluations of TCM. The bookalso: Describes the mechanisms of TCM at the molecular and systemslevels using chemomics, genomics, proteomics, metabolomics, andbioinformatics Places modern scientific technologies within the context ofTCM, helping drug researchers improve experimental designs andstrategies Illustrates how a systems biology approach is compatible withTCM's traditional, holistic therapeutic strategies and treatmentmodalities Presents topics of current interest, such as integrated globalsystems biology and the application of chemometrics research toherbal medicines This book not only opens a new pathway for the continueddevelopment of TCM, but also for systems biology. In addition, itfosters collaboration and discussion among Eastern and Westernscientists by applying systems biology to TCM.

Systems Biology and Its Application in TCM Formulas Research

Systems Biology and Its Application in TCM Formulas Research
Author: Wei-Dong Zhang
Publsiher: Academic Press
Total Pages: 380
Release: 2018-02-16
Genre: Medical
ISBN: 9780128127452

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Systems Biology and Its Application in TCM Formulas Research presents a theoretical research system formed for Traditional Chinese Medicine (TCM) formulas, along with information on the study of Shexiang Baoxin Pill (SBP), a TCM formula that has shown significant clinical efficacy in the treatment of cardiovascular diseases. The content combines theory and practice, and includes guidance for both theoretical concepts and operable technical routes. This is a valuable source not only for biomedical researchers involved in Systems Biology studies, but also for students and scientists interested in learning more about Traditional Chinese Medicine and its applications in contemporary medicine. Explains, in detail, the Shexiang Baoxin Pill (SBP), a TCM formula efficiently applied in the treatment of cardiovascular diseases Presents TCM formulas from perspectives of systems biology, basic chemical material groups, modern pharmacology and network biology Offers an overview on biology, modern chemistry and information technology as applied in Systems Biology research