Molecular Genetic and Statistical Techniques for Behavioral and Neural Research

Molecular Genetic and Statistical Techniques for Behavioral and Neural Research
Author: Robert T. Gerlai
Publsiher: Academic Press
Total Pages: 708
Release: 2018-04-24
Genre: Medical
ISBN: 9780128041161

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Molecular-Genetic and Statistical Techniques for Behavioral and Neural Research presents the most exciting molecular and recombinant DNA techniques used in the analysis of brain function and behavior, a critical piece of the puzzle for clinicians, scientists, course instructors and advanced undergraduate and graduate students. Chapters examine neuroinformatics, genetic and neurobehavioral databases and data mining, also providing an analysis of natural genetic variation and principles and applications of forward (mutagenesis) and reverse genetics (gene targeting). In addition, the book discusses gene expression and its role in brain function and behavior, along with ethical issues in the use of animals in genetics testing. Written and edited by leading international experts, this book provides a clear presentation of the frontiers of basic research as well as translationally relevant techniques that are used by neurobehavioral geneticists. Focuses on new techniques, including electrocorticography, functional mapping, stereo EEG, motor evoked potentials, optical coherence tomography, magnetoencephalography, laser evoked potentials, transmagnetic stimulation, and motor evoked potentials Presents the most exciting molecular and recombinant DNA techniques used in the analysis of brain function and behavior Written and edited by leading international experts

Handbook of Molecular Genetic Techniques for Brain and Behavior Research

Handbook of Molecular Genetic Techniques for Brain and Behavior Research
Author: Wim E. Crusio,R.T. Gerlai
Publsiher: Elsevier
Total Pages: 962
Release: 1999-10-18
Genre: Psychology
ISBN: 0080536867

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The book gives a broad overview of recombinant DNA techniques for the behavioral neuroscientist, with illustrative examples of applications. Species covered include rodents (mainly mice), Drosophila melanogaster, Caenorhabditis elegans and Danio rerio. Experimental techniques required to characterize the behavioral phenotypes of mutant animals is provided. Several aspects of novel molecular-genetic techniques are overviewed and possible research strategies are explained. The sections of the book start with general descriptions of techniques followed by illustrative examples. It is divided into six sections. Section 1, bioinformatics and genomics research. Section 2, top-down strategies, where the researcher starts with the phenotype and then analyzes the associated genes; bottom-up strategies, where the physiological chain leading to a phenotype is analyzed starting from the gene product. Section 3, transgenic approaches in rodents including overexpressing foreign genes and gene-targeting; systemic manipulation approaches directly targeting the central nervous system and methods used with invertebrates. Section 4, methods used to evaluate relevant behavioral phenotypes, including learning and aggression. Section 5, examples on molecular brain research in man. Section 6, ethical aspects of research in this field.

Behavioral and Neural Genetics of Zebrafish

Behavioral and Neural Genetics of Zebrafish
Author: Robert T. Gerlai
Publsiher: Academic Press
Total Pages: 614
Release: 2020-04-03
Genre: Medical
ISBN: 9780128175293

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Behavioral and Neural Genetics of Zebrafish assembles the state-of-the-art methodologies and current concepts pertinent to their neurobehavioral genetics. Discussing their natural behavior, motor function, learning and memory, this book focuses on the fry and adult zebrafish, featuring a comprehensive account of modern genetic and neural methods adapted to, or specifically developed for, Danio rerio. Numerous examples of how these behavioral methods may be utilized for disease models using the zebrafish are presented, as is a section on bioinformatics and "big-data" related questions. Provides the most comprehensive snapshot of the fast-evolving zebrafish neurobehavior genetics field Describes behavioral, genetic and neural methods and concepts for use in adult and larval zebrafish Features examples of zebrafish models of human central nervous system disorders Discusses bioinformatics questions pertinent to zebrafish neurobehavioral genetics

Translational Research in Cancer

Translational Research in Cancer
Author: Sivapatham Sundaresan,Yeun-Hwa Gu
Publsiher: BoD – Books on Demand
Total Pages: 210
Release: 2021-02-03
Genre: Medical
ISBN: 9781838805340

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Translational research in oncology benefits from an abundance of knowledge resulting from genome-scale studies concerning the molecular pathways involved in tumorigenesis. Translational oncology represents a bridge between basic research and clinical practice in cancer medicine. The vast majority of cancer cases are due to environmental risk factors. Many of these environmental factors are controllable lifestyle choices. Experimental cancer treatments are studied in clinical trials to compare the proposed treatment to the best existing treatment through translational research. The key features of the book include: 1) New screening for the development of radioprotectors: radioprotection and anti-cancer effect of β-Glucan (Enterococcus faecalis) 2) Translational perspective on hepatocellular carcinoma 3) Brachytherapy for endometrial cancer 4) Discovery of small molecule inhibitors for histone methyltransferases in cancer

Genetics and the Psychology of Motor Performance

Genetics and the Psychology of Motor Performance
Author: Sigal Ben-Zaken,Véronique Richard,Gershon Tenenbaum
Publsiher: Routledge
Total Pages: 200
Release: 2019-02-01
Genre: Medical
ISBN: 9781351628426

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Despite the prevalence of behavioral research conducted through genetic studies, there is an absence of literature pertaining to the genetics of motor behavior. Genetics and the Psychology of Motor Performance is the first book to integrate cutting-edge genetic research into the study of the psychological aspects of motor learning and control. The book’s central line of enquiry revolves around the extent to which psychological factors central to motor proficiency – including personality, emotion, self-regulation, motivation, and perceptual-cognitive skills – are acquired or inherited. It explains how these factors affect motor performance, distilling the latest research into their genetic underpinnings and, in doing so, assessing the magnitude of the role genetics plays in the stages of motor development, from early proficiency through to expertise. Written by leading experts in the genetics of human performance and exercise psychology, and thoroughly illustrated throughout, Genetics and the Psychology of Motor Performance is a crucial resource for any upper-level student or researcher seeking a deeper understanding of motor learning. It is an important book for anyone studying or working in exercise psychology, motor development, exercise genetics, or exercise physiology more broadly.

Neuroscience of Social Stress

Neuroscience of Social Stress
Author: Klaus A. Miczek
Publsiher: Springer Nature
Total Pages: 135
Release: 2022
Genre: Electronic Book
ISBN: 9783031042560

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Nanotherapeutic Strategies and New Pharmaceuticals Part 2

Nanotherapeutic Strategies and New Pharmaceuticals  Part 2
Author: Shahid Khan
Publsiher: Bentham Science Publishers
Total Pages: 285
Release: 2021-12-07
Genre: Medical
ISBN: 9789815036732

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Advances in technology have enabled medicinal chemists to discover and formulate several highly specific, biocompatible, and non-toxic therapeutic agents for clinical applications. Nanotechnology has achieved significant progress in the last few decades and is crucial in every field of science and technology. Nanotechnology-based pharmaceuticals offer multifaceted and alternative methodologies in comparison to the limitations of many conventional clinical therapies. Expertise in designing and developing nanoformulations has helped in targeted drug delivery. Recently, the use of innovative therapeutic agents, particularly in nanomedicine, has accounted for a significant portion of the global pharmaceutical market and is predicted to continue to grow rapidly in the near future. Nanotherapeutic Strategies and New Pharmaceuticals is an accessible multi-part reference which informs the reader about several new techniques based on nanotechnology. The chapters explain relevant topics in detail. The book is designed to encourage and help undergraduate, graduate and post-graduate students in the field of nanotherapeutics, pharmaceuticals and bio-organic chemistry through the use of didactic language and simple illustrations. Part 2 of this book covers the potential of nanotherapeutics and natural therapies for treating neurological diseases, targeting ion channels, signal transduction therapy, gene therapy of single gene mutation diseases and for nanoformulations for special purposes such as wound healing and stimuli-responsive drug delivery. The book also features a chapter that summarizes the types of nanoparticles tailored for specific molecular targets that mediate different diseases. The book set serves as a textbook for students in pharmacology and medical biochemistry, as well as a quick reference for researchers on bio-organic chemistry, as well as general readers interested in nanomedicine.

Knowledge Modelling and Big Data Analytics in Healthcare

Knowledge Modelling and Big Data Analytics in Healthcare
Author: Mayuri Mehta,Kalpdrum Passi,Indranath Chatterjee,Rajan Patel
Publsiher: CRC Press
Total Pages: 362
Release: 2021-12-09
Genre: Computers
ISBN: 9781000477764

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Knowledge Modelling and Big Data Analytics in Healthcare: Advances and Applications focuses on automated analytical techniques for healthcare applications used to extract knowledge from a vast amount of data. It brings together a variety of different aspects of the healthcare system and aids in the decision-making processes for healthcare professionals. The editors connect four contemporary areas of research rarely brought together in one book: artificial intelligence, big data analytics, knowledge modelling, and healthcare. They present state-of-the-art research from the healthcare sector, including research on medical imaging, healthcare analysis, and the applications of artificial intelligence in drug discovery. This book is intended for data scientists, academicians, and industry professionals in the healthcare sector.

Neurobehavioral Genetics

Neurobehavioral Genetics
Author: Byron C. Jones,Pierre Mormede
Publsiher: CRC Press
Total Pages: 496
Release: 2006-08-30
Genre: Medical
ISBN: 9781420003567

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A complete background to concepts and principles of behavioral genetics, Neurobehavioral Genetics: Methods and Applications, Second Edition features a broad spectrum of the most current techniques in neurobehavioral genetics in a single source. International researchers incorporate several new developments in the field, including: De

Methods in Genomic Neuroscience

Methods in Genomic Neuroscience
Author: Hemin R. Chin,Steven O. Moldin
Publsiher: CRC Press
Total Pages: 344
Release: 2001-09-26
Genre: Science
ISBN: 9781420038477

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The past few years have witnessed extraordinary advances in molecular genetic techniques and the accumulation of structural genomics information and resources in both human and model organisms. With the development of new technologies and the availability of resources like the sequence of eukaryotic genomes, problems of a previously unthinkable sco

Encyclopedia of Biomedical Gerontology

Encyclopedia of Biomedical Gerontology
Author: Anonim
Publsiher: Academic Press
Total Pages: 1640
Release: 2019-11-20
Genre: Medical
ISBN: 9780128160763

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Encyclopedia of Biomedical Gerontology presents a wide range of topics, ranging from what happens in the body during aging, the reasons and mechanisms relating to those age-related changes, and their clinical, psychological and social modulators and determinants. The book covers the biological and medical aspects of gerontology within the general framework of the biological basis of assessing age, biological mechanisms of aging, age-related changes in biological systems, human age-related diseases, the biomedical practicality and impracticality of interventions, and finally, the ethics of intervention. Provides a ‘one-stop’ resource to information written by world-leading scholars in the field of biomedical gerontology Fills a critical gap of information in a field that has seen significant progress in the last 10 years

Behavior Genetics of Cognition Across the Lifespan

Behavior Genetics of Cognition Across the Lifespan
Author: Deborah Finkel,Chandra A. Reynolds
Publsiher: Springer Science & Business Media
Total Pages: 300
Release: 2013-07-09
Genre: Psychology
ISBN: 9781461474470

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Along with psychopathology, cognition has been one of the primary phenotypic focal points of the field of behavior genetics since its inception. Francis Galton’s 1874 examination of eminent families in Britain was among the earliest attempts to investigate whether cognitive achievements run in families. This volume presents current methodologies for understanding cognitive abilities that move beyond the outdated nature vs. nurture paradigm. Recent advances in both collection and statistical modeling of twin data, particularly longitudinal twin data, make this an especially advantageous moment to produce a work that presents a collection of the groundbreaking research on cognitive abilities across the lifespan. This volume presents an overview of the current state of quantitative and molecular genetic investigations into the many facets of cognitive performance and functioning across the lifespan.​

Insect Molecular Genetics

Insect Molecular Genetics
Author: Marjorie A. Hoy
Publsiher: Academic Press
Total Pages: 705
Release: 2018-09-12
Genre: Science
ISBN: 9780128152317

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Describes how molecular tools solve problems in insect behaviour, ecology, systematics and evolution, and pest management

Handbook of the Psychology of Aging

Handbook of the Psychology of Aging
Author: K Warner Schaie,Sherry L. Willis
Publsiher: Academic Press
Total Pages: 434
Release: 2010-12-21
Genre: Medical
ISBN: 0123808839

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The Handbook of the Psychology of Aging, Seventh Edition, provides a basic reference source on the behavioral processes of aging for researchers, graduate students, and professionals. It also provides perspectives on the behavioral science of aging for researchers and professionals from other disciplines. The book is organized into four parts. Part 1 reviews key methodological and analytical issues in aging research. It examines some of the major historical influences that might provide explanatory mechanisms for a better understanding of cohort and period differences in psychological aging processes. Part 2 includes chapters that discuss the basics and nuances of executive function; the history of the morphometric research on normal brain aging; and the neural changes that occur in the brain with aging. Part 3 deals with the social and health aspects of aging. It covers the beliefs that individuals have about how much they can control various outcomes in their life; the impact of stress on health and aging; and the interrelationships between health disparities, social class, and aging. Part 4 discusses the emotional aspects of aging; family caregiving; and mental disorders and legal capacities in older adults. Contains all the main areas of psychological gerontological research in one volume Entire section on neuroscience and aging Begins with a section on theory and methods Edited by one of the father of gerontology (Schaie) and contributors represent top scholars in gerontology

Encyclopedia of Applied Developmental Science

Encyclopedia of Applied Developmental Science
Author: Celia B Fisher,Richard M. Lerner
Publsiher: SAGE Publications
Total Pages: 1360
Release: 2004-10-16
Genre: Psychology
ISBN: 9781452265223

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The Encyclopedia of Applied Developmental Science is an important and timely contribution to this burgeoning field. This four-volume set is the authoritative source that encompasses the entire range of concepts and topics involved in the study of applied developmental science. Its contents and levels have broad appeal for those interested in how the application of knowledge about human development can be used to enhance the lives of individuals, families, and communities.