Neuroprotection in Alzheimer s Disease

Neuroprotection in Alzheimer s Disease
Author: Illana Gozes
Publsiher: Academic Press
Total Pages: 342
Release: 2016-12-30
Genre: Medical
ISBN: 9780128037126

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Neuroprotection in Alzheimer’s Disease offers a translational point-of-view from both basic and clinical standpoints, putting it on the cusp for further clinical development with its emphasis on nerve cell protection, including the accumulation of knowledge from failed clinical trials and new advances in disease management. This book brings together the latest findings, both basic, and clinical, under the same cover, making it easy for the reader to obtain a complete overview of the state-of-the-field and beyond. Alzheimer's disease is the most common form of dementia, accounting for 60 to 80 percent of dementia cases. It is a progressive brain disease that slowly destroys memory, thinking skills, and eventually, even the ability to carry out the simplest tasks. It is characterized by death of synapses coupled to death nerve cells and brain degeneration which is manifested by loss of cognitive abilities. Understanding neuroprotection in Alzheimer’s disease will pave the path to better disease management and novel therapeutics. Comprehensive reference detailing neuroprotection in Alzheimer’s Disease, with details on nerve cell protection and new advances in disease management Combines the knowledge and points-of-view of both medical doctors and basic scientists, putting the subject at the forefront for further clinical development Edited by one of the leading researchers in Alzheimer’s Disease

Neuroprotection in Autism Schizophrenia and Alzheimer s Disease

Neuroprotection in Autism  Schizophrenia and Alzheimer s Disease
Author: Illana Gozes,Joseph Levine
Publsiher: Academic Press
Total Pages: 250
Release: 2019-11
Genre: Electronic Book
ISBN: 0128140372

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Some shared pathophysiological mechanisms underlie autism, schizophrenia/mood disorders and Alzheimer's disease, i.e. neurodevelopmental disorders, neuropsychiatric diseases and neurodegenerative disorders. With the rapid advancement of molecular genetics including single cell analysis and detailed molecular characteristics, scientists have the opportunity to follow up on novel mechanistic aspects and offer a novel perspective for the treatments. Neuroprotection in Autism, Schizophrenia and Alzheimer's Disease provides an up-to-date overview of basic and clinical studies concerning similarities in the most prevalent brain disorders, shedding light on basic mechanisms and providing for new avenues for early diagnosis toward disease prevention and disease modification. It is a collaborative effort between basic scientists, clinicians and educators and will open new horizons for the future researchers, medical professional and society at large. This book is written for researchers, clinicians, and medical physicians in neuroscience, neurology and psychiatry.

Neuroprotection

Neuroprotection
Author: Matilde Otero-Losada,Francisco Capani,Santiago Perez Lloret
Publsiher: BoD – Books on Demand
Total Pages: 348
Release: 2020-11-26
Genre: Medical
ISBN: 9781838804398

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Neurological disease affects nearly 25%–30% of the world’s population, exerting enormous financial strain on the healthcare system. Estimated current costs are around $800 annual billion, and this number is expected to increase exponentially as the global population ages. As such, new and alternative neuroprotective strategies are urgently needed. This book examines some of the most promising approaches in neuroprotection as well as discusses current goals and prospects. Organized into three sections, chapters cover such topics as the use of cannabinoids, medicinal plants, and essential oils in Alzheimer’s and Parkinson’s; protein misfolding and the neuroprotective potential of vitamin E in cerebral ischemia; and potential new neurological treatments and their mechanisms of action.

Alzheimer s Disease

Alzheimer   s Disease
Author: Ralph W. Richter,Brigitte Zoeller Richter
Publsiher: Springer Science & Business Media
Total Pages: 479
Release: 2003-10-10
Genre: Medical
ISBN: 9781592596614

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Alzheimer’s disease (AD) is a devastating and dehumanizing illness affecting increasingly large numbers of elderly and even middle-aged persons in a worldwide epidemic. Alzheimer’s Disease: A Physician’s Guide to Practical Management was written by selected clinicians and scientists who represent some of the world’s leading centers of excellence in AD research. The editors are proud and grateful for their profound contributions. This book is particularly designed to assist physicians and other health-care professionals in the evaluation, assessment, and treatment of individuals with AD. At the same time, by illuminating the basic scientific background, we hope to provide state-of-the art information about the disease and possible future therapeutic strategies. The recent psychiatric treatment aspects of AD are also clearly presented. Because the early diagnosis of the dementia process is now considered of increasing importance, we focus particularly in several chapters on early changes and preclinical conditions, such as mild cognitive impairment and predementia AD.

Neuroprotective Natural Products

Neuroprotective Natural Products
Author: Goutam Brahmachari
Publsiher: John Wiley & Sons
Total Pages: 376
Release: 2017-03-01
Genre: Medical
ISBN: 9783527803804

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Focusing on the molecular mechanisms of powerful naturally occurring agents and their implication for drug discovery, this timely book presents an overview of the most recent research advances in the field of bioactive natural products and natural drug formulations to combat today's destructive diseases. To this extent, the authors discuss the most severe neurological disorders in our modern civilization, such as Alzheimer's, Parkinson's and Huntington's disease, as well as ischemic brain stroke and depression. The emerging diversity of active compounds is covered in detail, including flavonoids, cannabinoids and oleanolic acid, while experts in the field explain the chemistry, mode of action and clinical aspects of novel neuroprotective natural products. In each case, the benefits of treatments using natural products are addressed from the perspective of modern as well as traditional medicine. With its multidisciplinary viewpoint, this is the ideal companion for medicinal and natural products chemists as well as neuroscientists, biochemists, pharmacologists, neurobiologists, and phytotherapists.

The Handbook of Alzheimer s Disease and Other Dementias

The Handbook of Alzheimer s Disease and Other Dementias
Author: Andrew E. Budson,Neil W. Kowall
Publsiher: John Wiley & Sons
Total Pages: 504
Release: 2011-09-09
Genre: Psychology
ISBN: 9781444344097

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The reference is a broad-ranging review of Alzheimer's disease and other dementias from both basic and clinical neuroscience perspectives; it provides scientists and medical professionals with an extensive introduction and an up-to-date review of cutting-edge scientific advances. Brings the reader up-to-date with cutting-edge developments in this exciting and fast-paced field Summarizes the most recent developments in the fields of Alzheimer's disease and dementia Brings together articles from a prominent and international group of contributors Encompasses a unique range of topics, combining basic molecular perspectives and cognitive neurosciences

Molecular Mechanisms and Therapeutic Strategies in Alzheimer s Disease

Molecular Mechanisms and Therapeutic Strategies in Alzheimer s Disease
Author: Veer Gupta,Vivek Gupta
Publsiher: LAP Lambert Academic Publishing
Total Pages: 240
Release: 2012
Genre: Electronic Book
ISBN: 3844385843

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This book provides an insight into the mechanism on the role of amino acid stereospecificity based amyloid beta aggregation pattern; non-apoptotic amyloid beta peptide induced DNA nicking and neuro-neutraceutical property of garlic and curcumin derivatives. These findings provide a molecular understanding of the neurodegeneration and neuroprotection in Alzheimers Disease brain. Novel neuroprotective strategies to treat various neurodegenrative disorders are discussed.

Oxidative Stress and Neurodegenerative Disorders

Oxidative Stress and Neurodegenerative Disorders
Author: G. Ali Qureshi,S. Hasan Parvez
Publsiher: Elsevier
Total Pages: 794
Release: 2007-03-22
Genre: Science
ISBN: 0080489494

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Oxidative stress is the result of an imbalance in pro-oxidant/antioxidant homeostasis that leads to the generation of toxic reactive oxygen species. Brain cells are continuously exposed to reactive oxygen species generated by oxidative metabolism, and in certain pathological conditions defense mechanisms against oxygen radicals may be weakened and/or overwhelmed. DNA is a potential target for oxidative damage, and genomic damage can contribute to neuropathogenesis. It is important therefore to identify tools for the quantitative analysis of DNA damage in models on neurological disorders. This book presents detailed information on various neurodegenerative disorders and their connection with oxidative stress. This information will provide clinicians with directions to treat these disorders with appropriate therapy and is also of vital importance for the drug industries for the design of new drugs for treatment of degenerative disorders. * Contains the latest information on the subject of neurodegenerative disorders * Reflects on various factors involved in degeneration and gives suggestions for how to tackle these problems

Nicotinic Acetylcholine Receptor Signaling in Neuroprotection

Nicotinic Acetylcholine Receptor Signaling in Neuroprotection
Author: Shun Shimohama,Akinori Akaike,Yoshimi Misu
Publsiher: Unknown
Total Pages: 196
Release: 2020-10-08
Genre: Medical
ISBN: 1013269748

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This open access book presents the roles and mechanisms of signal transduction triggered by nicotinic acetylcholine receptors (nAChRs) stimulation in neuroprotection against toxic effects of risk factors of neurodegenerative diseases. Accumulating evidence suggests that nAChRs in the CNS play important roles not only in excitatory neurotransmission but also in neuronal survival and related functions. Neuroprotection mediated by nAChRs in neurodegenerative diseases such as Alzheimer's disease is the major topic of this book. In response to rapidly evolving areas in clinical and laboratory neuropharmacology and neurochemistry, this volume provides in-depth coverage of neuroprotection in basic research and future developments in the clinical application of effective neuroprotective strategies in neurodegenerative diseases. This work appeals to both basic and clinical researchers in several fields, such as neuroscience, neurology, and pharmacology. This work was published by Saint Philip Street Press pursuant to a Creative Commons license permitting commercial use. All rights not granted by the work's license are retained by the author or authors.

Hormones Cognition and Dementia

Hormones  Cognition and Dementia
Author: Eef Hogervorst,Victor W. Henderson,Robert B. Gibbs,Roberta Diaz Brinton
Publsiher: Cambridge University Press
Total Pages: 135
Release: 2009-09-24
Genre: Medical
ISBN: 9781139483650

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A decade ago, oestrogen-containing hormone therapy was viewed as a promising strategy for the prevention and treatment of dementia and age-related cognitive decline. However, treatment trials in women with Alzheimer's disease showed that oestrogens did not reverse cognitive impairment, and clinical trials in healthy older women indicated that oestrogens did not prevent cognitive decline. The Women's Health Initiative Memory Study trial even suggested an increased risk of dementia with treatment late in life. What happened? How are we to understand these findings? What are the implications for middle-aged and older women? What about testosterone, and what about men? And where do we go from here? This book brings together world-renowned experts in basic and clinical research on sex steroids, aging, and cognition to integrate existing findings with emerging new data, and offer challenging hypotheses on these key issues.

Neurodegenerative Diseases

Neurodegenerative Diseases
Author: Uday Kishore
Publsiher: BoD – Books on Demand
Total Pages: 640
Release: 2013-05-15
Genre: Medical
ISBN: 9789535110880

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This book highlights the pathophysiological complexities of the mechanisms and factors that are likely to be involved in a range of neuroinflammatory and neurodegenerative diseases including Alzheimer's disease, other Dementia, Parkinson Diseases and Multiple Sclerosis. The spectrum of diverse factors involved in neurodegeneration, such as protein aggregation, oxidative stress, caspases and secretase, regulators, cholesterol, zinc, microglia, astrocytes, oligodendrocytes, etc, have been discussed in the context of disease progression. In addition, novel approaches to therapeutic interventions have also been presented. It is hoped that students, scientists and clinicians shall find this very informative book immensely useful and thought-provoking.

Neuroprotection in Autism Schizophrenia and Alzheimer s disease

Neuroprotection in Autism  Schizophrenia and Alzheimer s disease
Author: Illana Gozes,Joseph Levine
Publsiher: Academic Press
Total Pages: 322
Release: 2019-10-16
Genre: Medical
ISBN: 9780128140383

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Neuroprotection in Autism, Schizophrenia and Alzheimer's Disease provides an up-to-date overview on recent clinical studies and the similarities discovered in the most prevalent brain disorders. The book's content will help shed light on basic mechanisms and provide new avenues for early diagnosis toward disease prevention and disease modification. It is written for researchers, clinicians and medical physicians in neuroscience, neurology and psychiatry. Sections discuss the shared pathophysiological mechanisms that underlie autism, schizophrenia/mood disorders and Alzheimer’s disease, i.e. neurodevelopmental disorders, neuropsychiatric diseases and neurodegenerative disorders. Offers an up-to-date overview of basic and clinical studies concerning similarities in the most prevalent brain disorders Helps the reader become familiar with novel neuroprotective mechanisms and experimental treatment modalities in these difficult to treat disorders Written for researchers, clinicians and medical physicians in neuroscience, neurology and psychiatry

Natural Products and Neuroprotection

Natural Products and Neuroprotection
Author: Cristina Angeloni,David Vauzour
Publsiher: MDPI
Total Pages: 338
Release: 2020-06-17
Genre: Science
ISBN: 9783039362165

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Neurodegenerative diseases, including Alzheimer’s, Parkinson’s, Huntington’s, and amyotrophic lateral sclerosis, are the most common pathologies of the central nervous system currently without a cure. They share common molecular and cellular characteristics, including protein misfolding, mitochondrial dysfunction, glutamate toxicity, dysregulation of calcium homeostasis, oxidative stress, inflammation, and ageing, which contribute to neuronal death. Efforts to treat these diseases are often limited by their multifactorial etiology. Natural products, thanks to their multitarget activities, are considered promising alternatives for the treatment of neurodegeneration. This book deals with two different forms of natural products: extracts and isolated compounds. The study of the bioactivity of the extracts is extremely important as many studies have demonstrated the synergistic effect of the combination of different natural products. On the other hand, the investigation of the activity of specifically isolated natural products can be also important to understand their cellular and molecular mechanisms and to define the specific bioactive components in extracts or foods. This book can be considered an important contribution to knowledge of the neuroprotective effect of natural products and presents a great deal of information, related to both the benefits but also the limitations of their use in counteracting neurodegeneration.

Nanomedicine and Neuroprotection in Brain Diseases

Nanomedicine and Neuroprotection in Brain Diseases
Author: Hari Shanker Sharma,Aruna Sharma
Publsiher: Elsevier
Total Pages: 442
Release: 2021-09-22
Genre: Psychology
ISBN: 9780323901635

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Progress in Brain Research series, highlights new advances in the field, with this new volume presenting interesting chapters. Each chapter is written by an international board of authors. Provides the authority and expertise of leading contributors from an international board of authors Presents the latest release in the Progress in Brain Research series Updated release includes the latest information on the Neuropharmacology of Neuroprotection

Phytochemical Omics in Medicinal Plants

Phytochemical Omics in Medicinal Plants
Author: Jen-Tsung Chen
Publsiher: MDPI
Total Pages: 542
Release: 2021-08-18
Genre: Medical
ISBN: 9783036512945

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Medicinal plants are used to treat diseases and provide health benefits, and their applications are increasing around the world. A huge array of phytochemicals have been identified from medicinal plants, belonging to carotenoids, flavonoids, lignans, and phenolic acids, and so on, with a wide range of biological activities. In order to explore our knowledge of phytochemicals with the assistance of modern molecular tools and high-throughput technologies, this book collects recent innovative original research and review articles on subtopics of mechanistic insights into bioactivities, treatment of diseases, profiling, extraction and identification, and biotechnology.