Practical Process Research and Development A guide for Organic Chemists

Practical Process Research and Development     A guide for Organic Chemists
Author: Neal G. Anderson
Publsiher: Academic Press
Total Pages: 488
Release: 2012-05-23
Genre: Science
ISBN: 9780123865380

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Designed to provide a comprehensive, step-by-step approach to organic process research and development in the pharmaceutical, fine chemical, and agricultural chemical industries, this book describes the steps taken, following synthesis and evaluation, to bring key compounds to market in a cost-effective manner. It describes hands-on, step-by-step, approaches to solving process development problems, including route, reagent, and solvent selection; optimising catalytic reactions; chiral syntheses; and "green chemistry." Second Edition highlights: • Reflects the current thinking in chemical process R&D for small molecules • Retains similar structure and orientation to the first edition. • Contains approx. 85% new material • Primarily new examples (work-up and prospective considerations for pilot plant and manufacturing scale-up) • Some new/expanded topics (e.g. green chemistry, genotoxins, enzymatic processes) • Replaces the first edition, although the first edition contains useful older examples that readers may refer to Provides insights into generating rugged, practical, cost-effective processes for the chemical preparation of "small molecules" Breaks down process optimization into route, reagent and solvent selection, development of reaction conditions, workup, crystallizations and more Presents guidelines for implementing and troubleshooting processes

Practical Process Research Development

Practical Process Research   Development
Author: Neal G. Anderson
Publsiher: Academic Press
Total Pages: 354
Release: 2000-03
Genre: Science
ISBN: 1483299775

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This book provides a comprehensive, step-by-step approach to organic process research and development in the pharmaceutical, fine chemical, and agricultural chemical industries. Process R&D describes the steps taken, following synthesis and evaluation, to bring key compounds to market in a cost-effective manner. More people are being hired for work in this area as increasing numbers of drug candidates are identified through combinatorial chemistry and high-throughput screening. The book is directed to industrial (primarily organic) chemists, and academicians (particularly those involved in a growing number of start-up companies) and students who need insight into industrial process R&D. Current books do not describe hands-on, step-by-step, approaches to solving process development problems, including route, reagent, and solvent selection; optimising catalytic reactions; chiral syntheses; and "green chemistry." "Practical Process Research and Development" will be a valuable resource for researchers, managers, and graduate students. * Provides insights into generating rugged, practical, cost-effective processes for the chemical preparation of "small molecules" * Breaks down process optimization into route, reagent and solvent selection, development of reaction conditions, workup, crystallizations and more * Includes over 100 tips for rapid process development * Presents guidelines for implementing and troubleshooting processes

Research for Development

Research for Development
Author: Sophie Laws
Publsiher: SAGE
Total Pages: 475
Release: 2003-06-25
Genre: Political Science
ISBN: 0761973273

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`[Research for Development] is well-written and, at every stage, is well-documented with practical examples. The simplicity with which it is written adds to its value in that non-professional persons get well-aquainted with the research process. Every chapter in the book ends with highlighting of the main points made in that chapter... A further strength of the book is the inclusion of an appendix with a list of websites that deal with issues in the area of development research... the simplicity of its organization and message should appeal to people/researchers across disciplines' - Pakistan Development Review `Research for Development achieves the near impossible: it provides vast quantities of useful guidance for almost anyone involved in research for development regardless of the size of your research project or your role within that project' - Arvac Bulletin `Written by professional researchers, this immensely practical book provides development workers with a more research-oriented point of view, so that they can avoid mistakes in the design of programmes. It will also help them to understand people's needs and respond accordingly' - The Asian Age `It is a beautiful and comprehensive compilation giving scores of instances that prove the essentiality if carrying out a survey of a particular locality for bringing about a change there' - Rafique Jalal, DAWN This book provides a comprehensive introduction and handbook for undertaking and managing research in development. It is designed to provide both a quick reference manual and an indispensable learning tool for all students, researchers and practitioners engaged in development work. The text is divided into two parts: Managing research for development, and Doing research for development. Together the two parts review the complete research process from outlining the essential role and purpose of research, highlighting specific issues to development research, to demonstrating how to evaluate and secure the best results from subsequent research projects. The book includes: an overview of different types of research in development work; practical steps to writing a brief and managing research; practical steps to evaluating and promoting research findings; step by step guides to getting started and choosing a research method; detailed guidelines to seven key research techniques; examples, exercises, summaries and checklists; and glossary and guides to additional resources and packages Drawing on considerable hands-on experience, Research for Development will be an essential companion and invaluable tool for anyone engaged in contemporary development research, development work and development studies.

Industrial Process Scale up

Industrial Process Scale up
Author: Jan Harmsen
Publsiher: Elsevier
Total Pages: 112
Release: 2013-04-25
Genre: Technology & Engineering
ISBN: 9780444627391

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This book will help industrial process innovators in research, development and commercial start-up to assess the risks of commercial-scale implementation and provide them with practical guidelines and methods to reduce the risks to acceptable levels. The book can also be used in co-operation with industrial R&D people and academic researchers to shape open innovation programs and in education as a reference book for process innovation courses. Offers easily accessible, step-by-step, and concise guidelines for industrial process scale-up Explains each stage of the innovation funnel: research, development, demonstration, commercial implementation for any process type and branch Based on industrial experiences and practices, which reduces the risks of commercial scale implementation of new processes to acceptable levels and reduces cost and time of process innovation Very clear, attractive layout, using text boxes that contain clarifying notes and additional information on specific topics, which makes it a quick reference of main subjects and additional information

A Practical Guide to Drug Development in Academia

A Practical Guide to Drug Development in Academia
Author: Daria Mochly-Rosen,Kevin Grimes
Publsiher: Springer Science & Business Media
Total Pages: 176
Release: 2014-07-08
Genre: Medical
ISBN: 9783319022017

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"A lot of hard-won knowledge is laid out here in a brief but informative way. Every topic is well referenced, with citations from both the primary literature and relevant resources from the internet." Review from Nature Chemical Biology Written by the founders of the SPARK program at Stanford University, this book is a practical guide designed for professors, students and clinicians at academic research institutions who are interested in learning more about the drug development process and how to help their discoveries become the novel drugs of the future. Often many potentially transformative basic science discoveries are not pursued because they are deemed ‘too early’ to attract industry interest. There are simple, relatively cost-effective things that academic researchers can do to advance their findings to the point that they can be tested in the clinic or attract more industry interest. Each chapter broadly discusses an important topic in drug development, from preclinical work in assay design through clinical trial design, regulatory issues and marketing assessments. After the practical overview provided here, the reader is encouraged to consult more detailed texts on specific topics of interest. "I would actually welcome it if this book’s intended audience were broadened even more. Younger scientists starting out in the drug industry would benefit from reading it and getting some early exposure to parts of the process that they’ll eventually have to understand. Journalists covering the industry (especially the small startup companies) will find this book a good reality check for many an over-hopeful press release. Even advanced investors who might want to know what really happens in the labs will find information here that might otherwise be difficult to track down in such a concentrated form."

Doing Developmental Research

Doing Developmental Research
Author: Tricia Striano
Publsiher: Guilford Publications
Total Pages: 177
Release: 2016-02-19
Genre: Social Science
ISBN: 9781462524426

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"Subject Areas/Keywords: child development, children, developmental psychology, developmental research methods, developmental science, early childhood, infancy research, infants, parents, preschoolers, research laboratory, research studies DESCRIPTION Addressing practical issues rarely covered in methods texts, this userfriendly, jargonfree book helps students and beginning researchers plan infant and child development studies and get them done. The author provides stepbystep guidance for getting involved in a developmental laboratory and crafting effective research questions and proposals. Tips on recruiting study participants cover access issues--such as how to overcome language and cultural barriers--and include helpful sample scripts. The book offers time management strategies, pointers for organizing and communicating data, and a roadmap of the journal publication process, complete with an annotated sample article. Numerous concrete examples, checklists, worksheets, and exercises are featured. Reproducible forms can be downloaded and printed in a convenient 8 1/2" x 11" size"--

Fishery Co Management

Fishery Co Management
Author: Robert S. Pomeroy,Rebecca Rivera-Guieb
Publsiher: CABI
Total Pages: 282
Release: 2005
Genre: Technology & Engineering
ISBN: 9780851990903

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During the last decade, there has been a shift in the governance and management of fisheries to a broaderapproach that recognizes the participation of fishers, local stewardship, and shared decision-making.Through this process, fishers are empowered to become active members of the management team,balancing rights and responsibilities, and working in partnership with government. This approach iscalled co-management.This handbook describes the process of community-based co-management from its beginning, throughimplementation, to turnover to the community. It provides ideas, methods, techniques, activities, checklists,examples, questions and indicators for the planning and implementing of a process of community-basedco-management. It focuses on small-scale fisheries (freshwater, floodplain, estuarine, or marine) indeveloping countries, but is also relevant to small-scale fisheries in developed countries and to themanagement of other coastal resources (such as coral reefs, mangroves, sea grass, and wetlands). Thishandbook will be of significant interest to resource managers, practitioners, academics and students ofsmall-scale fisheries.

Practical Aspects of Vaccine Development

Practical Aspects of Vaccine Development
Author: Parag Kolhe,Satoshi Ohtake
Publsiher: Elsevier
Total Pages: 386
Release: 2021-09-24
Genre: Business & Economics
ISBN: 9780128143575

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Formulation, Development and Manufacturing of Vaccines: The Practical Aspects provides an industry perspective on vaccine product development and manufacture that covers their formulation development, manufacture and delivery/in-use considerations of vaccine production. With the increasing complexity of vaccine products in development, there is a need for a comprehensive review of the current state of the industry and its challenges. While formulation scientists working in biotherapeutic development may be familiar with proteins, vaccines present unique challenges, including the wide range of vaccine components that may comprise proteins, polysaccharides, protein-polysaccharide conjugates, adjuvants, etc. and the varying stability and behavior of solution- and suspension-based systems. This book is an essential resource for formulation scientists, researchers in vaccine development throughout medical and life sciences, and advanced students. Includes formulation considerations for various vaccine types, including proteins, polysaccharides, conjugates and live vaccines Considers process development for solution, suspension and lyophilized products Explores the future potential of vaccines, including multi-component vaccines and novel delivery mechanisms/devices

Practical Synthetic Organic Chemistry

Practical Synthetic Organic Chemistry
Author: Stéphane Caron
Publsiher: John Wiley & Sons
Total Pages: 848
Release: 2020-01-31
Genre: Science
ISBN: 9781119448884

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This book is a hands-on guide for the organic chemist. Focusing on the most reliable and useful reactions, the chapter authors provide the information necessary for a chemist to strategically plan a synthesis, as well as repeat the procedures in the laboratory. Consolidates all the key advances/concepts in one book, covering the most important reactions in organic chemistry, including substitutions, additions, eliminations, rearrangements, oxidations, reductions Highlights the most important reactions, addressing basic principles, advantages/disadvantages of the methodology, mechanism, and techniques for achieving laboratory success Features new content on recent advances in CH activation, photoredox and electrochemistry, continuous chemistry, and application of biocatalysis in synthesis Revamps chapters to include new and additional examples of chemistry that have been demonstrated at a practical scale

Developmental Evaluation

Developmental Evaluation
Author: Michael Quinn Patton
Publsiher: Guilford Press
Total Pages: 375
Release: 2010-06-14
Genre: Psychology
ISBN: 9781606238868

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Developmental evaluation (DE) offers a powerful approach to monitoring and supporting social innovations by working in partnership with program decision makers. In this book, eminent authority Michael Quinn Patton shows how to conduct evaluations within a DE framework. Patton draws on insights about complex dynamic systems, uncertainty, nonlinearity, and emergence. He illustrates how DE can be used for a range of purposes: ongoing program development, adapting effective principles of practice to local contexts, generating innovations and taking them to scale, and facilitating rapid response in crisis situations. Students and practicing evaluators will appreciate the book's extensive case examples and stories, cartoons, clear writing style, "closer look" sidebars, and summary tables. Provided is essential guidance for making evaluations useful, practical, and credible in support of social change.

Design of Experiments in Chemical Engineering

Design of Experiments in Chemical Engineering
Author: Zivorad R. Lazic
Publsiher: John Wiley & Sons
Total Pages: 620
Release: 2006-03-06
Genre: Science
ISBN: 9783527604593

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While existing books related to DOE are focused either on process or mixture factors or analyze specific tools from DOE science, this text is structured both horizontally and vertically, covering the three most common objectives of any experimental research: * screening designs * mathematical modeling, and * optimization. Written in a simple and lively manner and backed by current chemical product studies from all around the world, the book elucidates basic concepts of statistical methods, experiment design and optimization techniques as applied to chemistry and chemical engineering. Throughout, the focus is on unifying the theory and methodology of optimization with well-known statistical and experimental methods. The author draws on his own experience in research and development, resulting in a work that will assist students, scientists and engineers in using the concepts covered here in seeking optimum conditions for a chemical system or process. With 441 tables, 250 diagrams, as well as 200 examples drawn from current chemical product studies, this is an invaluable and convenient source of information for all those involved in process optimization.

Overseas Research

Overseas Research
Author: Christopher Brendan Barrett,Jeffrey W. Cason
Publsiher: JHU Press
Total Pages: 142
Release: 1997
Genre: Social Science
ISBN: 0801855144

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Scholars and students engaged in overseas research projects often spend much of their time worrying about mundane details never reported in published research. In fact, the quality of scholarship often depends on the researcher's ability to navigate a bewildering array of social, financial, bureaucratic, and logistical obstacles encountered in preparing for, working in, and recovering from "the field." Overseas Research: A Practical Guide is the first book designed explicitly to prepare scholars and professionals for the real-life challenges of living and working abroad. Opening with a discussion of site selection and project funding, the authors advise researchers on preparing for departure, setting up residence in the field, conducting research in an unfamiliar environment, employing field assistants, and organizing for and adjusting to the return home. The text is supplemented with the insights, anecdotes, and tips from more than sixty scholars in a wide variety of disciplines who conducted research in more than forty countries.

Health Measurement Scales

Health Measurement Scales
Author: David L. Streiner,Geoffrey R. Norman,John Cairney
Publsiher: Oxford University Press, USA
Total Pages: 399
Release: 2015
Genre: Language Arts & Disciplines
ISBN: 9780199685219

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A new edition of this practical guide for clinicians who are developing tools to measure subjective states, attitudes, or non-tangible outcomes in their patients, suitable for those who have no knowledge of statistics.

Applied Research in Child and Adolescent Development

Applied Research in Child and Adolescent Development
Author: Valerie Maholmes,Carmela Gina Lomonaco
Publsiher: Psychology Press
Total Pages: 340
Release: 2011-01-11
Genre: Psychology
ISBN: 9781136988783

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Developed for an NIH training institute, this volume is organized around the most frequently asked questions by researchers starting their careers in applied research in child and adolescent development. With contributions from the leading scholars in the field, actual research experiences highlight the challenges one faces in conducting such research. The techniques and theoretical frameworks most suitable for guiding the applied research process are reviewed along with related ethical and cultural considerations. Each chapter features the authors’ introduction to their own careers in applied research. Also included are practical tips, case studies, and sidebars featuring frequently asked questions. This practical resource provides tips on how to: Modify the most frequently used methodological techniques while maintaining the integrity of the data Manage the unpredictable nature of real world research Frame community relevant research questions in an academically acceptable way Secure funding to conduct applied research Disseminate the research results so as to have the greatest impact on policy and practice. The book opens with the most frequently asked questions, tips on getting started in an applied research career, and an overview of and theoretical framework for generating applied developmental research ideas. Section 2 focuses on research designs including the most frequently used methodological and measurement techniques and tips on how to modify them to applied settings. Ethical challenges and cultural issues in working with special populations are also addressed. Section 3 focuses on conducting applied research in school, community, and clinical settings with an emphasis on the challenges encountered when conducting actual research as opposed to the more controlled settings taught in a classroom. Guidelines for protecting the populations involved in the study and strategies for recruiting and retaining participants are also addressed. The book concludes with strategies for disseminating research findings so as to have the greatest impact on policy and practice, for publishing research, and for securing funding. Intended as a practical guide, this book is ideal for those just starting their careers in applied research, for students preparing their dissertations, and for the faculty who prepare these students. The book’s accessible approach also appeals to researchers in the behavioral, social, and health sciences, education, and those in government and industry.

Design of Experiments for Pharmaceutical Product Development

Design of Experiments for Pharmaceutical Product Development
Author: Sarwar Beg
Publsiher: Springer Nature
Total Pages: 188
Release: 2021-01-22
Genre: Medical
ISBN: 9789813343511

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This book volume provides complete and updated information on the applications of Design of Experiments (DoE) and related multivariate techniques at various stages of pharmaceutical product development. It discusses the applications of experimental designs that shall include oral, topical, transdermal, injectables preparations, and beyond for nanopharmaceutical product development, leading to dedicated case studies on various pharmaceutical experiments through illustrations, art-works, tables and figures. This book is a valuable guide for all academic and industrial researchers, pharmaceutical and biomedical scientists, undergraduate and postgraduate research scholars, pharmacists, biostatisticians, biotechnologists, formulations and process engineers, regulatory affairs and quality assurance personnel.