Pulmonary Adenocarcinoma Approaches to Treatment

Pulmonary Adenocarcinoma  Approaches to Treatment
Author: Leora Horn
Publsiher: Elsevier Health Sciences
Total Pages: 400
Release: 2018-10-24
Genre: Medical
ISBN: 9780323554343

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Get a quick, expert overview of the latest treatment and management approaches for adenocarcinoma of the lung, including novel therapeutics in immunotherapy and targeted therapies. This practical title, edited by Dr. Leora Horn, offers succinct coverage of clinically-focused topics and guidelines, making it an ideal resource for practicing and trainee oncologists and other members of the cancer care team.

Targeted Therapies for Lung Cancer

Targeted Therapies for Lung Cancer
Author: Ravi Salgia
Publsiher: Springer
Total Pages: 238
Release: 2019-06-26
Genre: Medical
ISBN: 9783030178321

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This book contextualizes translational research and provides an up to date progress report on therapies that are currently being targeted in lung cancer. It is now well established that there is tremendous heterogeneity among cancer cells both at the inter- and intra-tumoral level. Further, a growing body of work highlights the importance of targeted therapies and personalized medicine in treating cancer patients. In contrast to conventional therapies that are typically administered to the average patient regardless of the patient’s genotype, targeted therapies are tailored to patients with specific traits. Nonetheless, such genetic changes can be disease-specific and/or target specific; thus, the book addresses these issues manifested in the somatically acquired genetic changes of the targeted gene. Each chapter is written by a leading medical oncologist who specializes in thoracic oncology and is devoted to a particular target in a specific indication. Contributors provide an in-depth review of the literature covering the mechanisms underlying signaling, potential cross talk between the target and downstream signaling, and potential emergence of drug resistance.

Update on the Treatment of Metastatic Non small Cell Lung Cancer NSCLC in New Era of Personalised Medicine

Update on the Treatment of Metastatic Non small Cell Lung Cancer  NSCLC  in New Era of Personalised Medicine
Author: Vera Hirsh,Barbara Melosky
Publsiher: Frontiers Media SA
Total Pages: 135
Release: 2018-01-24
Genre: Electronic Book
ISBN: 9782889453979

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Lung cancer remains a major cause of death in of both women and men in our society. Lung cancer treatment paradigms have changed enormously as we’ve started to understand the genetic complexity and the multiple driver mutations influencing the disease. Therapeutics directed towards, or to inhibit signaling pathways has resulted in increased life spans for our patients. Over the last two decades, we have gone from simple chemotherapy used to treat all, to a personalized medicine approach for the majority. For non-small cell lung cancer patients without driver mutations, the world of immune oncology has arrived. These improved long-term outcomes mean that now our lung cancer patients can live with their cancers, but without progression. The aim of this book is to catalogue the current state of knowledge for the many facets of advanced lung cancer. It describes current treatment approaches for driver mutations, rare mutations, and rare thoracic malignancies such as neuroendocrine tumors. Most importantly, this book addresses the topics of palliative treatment and care which allow our patients to enjoy longer survival with the highest quality of life. We hope you enjoy this e-book. The future is brighter for lung cancer patients and as lung cancer specialists; we finally feel sense optimism about treatment options for our patients.

Lung Cancer PART II An Issue of Clinics in Chest Medicine

Lung Cancer PART II  An Issue of Clinics in Chest Medicine
Author: M. Patricia Rivera,Richard A. Matthay
Publsiher: Elsevier Health Sciences
Total Pages: 240
Release: 2020-06-04
Genre: Medical
ISBN: 9780323791434

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This issue of Clinics in Chest Medicine, guest-edited by Dr. M. Patricia Rivera, is the second of two issues focused on Lung Cancer. Topics discussed in this issue include but are not limited to: Lung Cancer TNM Staging: The 8th Edition; New Surgical Approaches in the Treatment of NSCLC; Alternatives to Surgery for Early Stage Non-Small Cell Lung Cancer: Stereotactic Radiotherapy; Alternatives to Surgery for Early Stage Non-Small Cell Lung Cancer: Thermal Ablation; Advances in the Treatment of Stage III NSCLC; Advances in Treatment of NSCLC: Targeted Therapy; Advances in the Treatment of NSCLC: Immunotherapy; Treatment of Oligometastatic Disease in NSCLC; Management of Malignant Pleural Effusions; Advances in the Treatment of Small Cell Lung Cancer; Palliative Care and the Role of the Primary Care Physician in Lung Cancer Care; Pulmonary Complications of Immunotherapy; and Pulmonary Complications of Chemotherapy and Radiation Therapy.

Molecular Targeted Therapy of Lung Cancer

Molecular Targeted Therapy of Lung Cancer
Author: Yuichi Takiguchi
Publsiher: Springer
Total Pages: 327
Release: 2017-01-24
Genre: Medical
ISBN: 9789811020025

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This book discusses the latest molecular targeted therapy of lung cancer including its evaluation and future directions. It clearly illustrates the initial dramatic effectiveness of molecular targeted therapy, recurrence of the disease, overcoming the wide variety of resistance mechanisms using new-generation molecular targeted agents and potential novel approaches. It also outlines the increasing necessity for new diagnostic technology and strategies for managing different adverse effects and novel methods for evaluating effectiveness and safety. Edited and authored by opinion leaders, Molecular Targeted Therapy of Lung Cancer provides a comprehensive overview of the disease and its treatments. It is a valuable resource for graduate students, post-doctoral fellows and faculty staff, as well as researchers involved in clinical and translational research on lung cancer, helping promote new ideas for further advances.

Stereotactic Body Radiation Therapy

Stereotactic Body Radiation Therapy
Author: Simon S. Lo,Bin S. Teh,Jiade J. Lu,Tracey E. Schefter
Publsiher: Springer Science & Business Media
Total Pages: 421
Release: 2012-08-28
Genre: Medical
ISBN: 9783642256042

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Stereotactic body radiation therapy (SBRT) has emerged as an important innovative treatment for various primary and metastatic cancers. This book provides a comprehensive and up-to-date account of the physical/technological, biological, and clinical aspects of SBRT. It will serve as a detailed resource for this rapidly developing treatment modality. The organ sites covered include lung, liver, spine, pancreas, prostate, adrenal, head and neck, and female reproductive tract. Retrospective studies and prospective clinical trials on SBRT for various organ sites from around the world are examined, and toxicities and normal tissue constraints are discussed. This book features unique insights from world-renowned experts in SBRT from North America, Asia, and Europe. It will be necessary reading for radiation oncologists, radiation oncology residents and fellows, medical physicists, medical physics residents, medical oncologists, surgical oncologists, and cancer scientists.

Targeted Therapies in Lung Cancer Management Strategies for Nurses and Practitioners

Targeted Therapies in Lung Cancer  Management Strategies for Nurses and Practitioners
Author: Marianne Davies,Beth Eaby-Sandy
Publsiher: Springer
Total Pages: 120
Release: 2019-07-16
Genre: Medical
ISBN: 9783030165505

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This book aims to educate nurses and advanced practice providers (APP’s) about known mutations, availability of targeted therapy and the management of patients with non-small cell lung cancer (NSCLC). It will educate nurses and practitioners about the scope of therapy to assure safe and effective lung cancer treatment. In this era of personalized medicine, nurses and APP’s are responsible for guiding patients from diagnosis through treatment. This starts with the identification of patients that can benefit from these therapies, the key role of biopsy acquisition (ie. what to test, when and how often) and treatment selection based on the mutation identified. Readers will learn about the mechanisms of action, administration, potential adverse side effects and unique management strategies for these targeted agents. Lung cancer continues to be the leading cause of cancer death in the United States and worldwide. Recent advances in the identification of specific oncogenic mutations that drive cancer development, growth and metastasis have led to major paradigm shifts in lung cancer treatment. Sophisticated methods are required to identify specific mutations at the time of diagnosis. This book explains how molecularly targeted therapies have been developed that target these drivers. To date, several tyrosine kinase inhibitors have been approved to target the epidermal growth factor receptor (EGFR), EML4-ALK ,ROS1 and BRAF. Most recently, immune checkpoint inhibitors have been approved with some indication that efficacy may be enhanced for patients who overexpress PD-L1. While some driver mutations have been identified, there is ongoing investigation into additional mutations. In the case of driver mutations, lung cancers will develop resistance to therapy. This book provides nurses and APP’s with the mechanisms of resistance that have been identified such as T790 mutation and many others in the EGFR mutation, and shows how the next level of drug development is focused on identifying mechanisms of resistance and development of new agents that overcome these mutations. With this book in hand, nurses and practitioners will be able to navigate patients through this ever expanding field of lung cancer treatment.

Lung Cancer A Practical Approach to Evidence Based Clinical Evaluation and Management

Lung Cancer  A Practical Approach to Evidence Based Clinical Evaluation and Management
Author: Lynn T. Tanoue,Frank C Detterbeck
Publsiher: Elsevier Health Sciences
Total Pages: 350
Release: 2018-05-30
Genre: Medical
ISBN: 9780323496063

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Get a quick, expert overview of the many key facets of lung cancer evaluation and management with this concise, practical resource by Drs. Lynn T. Tanoue and Frank Detterbeck. This easy-to-read reference presents a summary of today’s best evidence-based approaches to diagnosis and management in this critical area. Covers diagnosis and evaluation, treatment considerations, and comprehensive care options for patients with lung cancer. Provides insight on evidence for today’s best practices, as well as future directions in the field. Consolidates today’s evidence-based information on the clinical aspects of lung cancer into one convenient resource.

Lung Cancer

Lung Cancer
Author: Jack A. Roth,James D. Cox,Waun Ki Hong
Publsiher: John Wiley & Sons
Total Pages: 480
Release: 2011-08-26
Genre: Medical
ISBN: 9781444358667

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Lung cancer is a major cause of cancer-related deaths in men and women. However, since the first edition of Lung Cancer was published 14 years ago, rapid progress in the biology, prevention, diagnosis, and treatment of the disease has been made.

BATTLE Biomarker Based Approaches of Targeted Therapy for Lung Cancer Elimination

BATTLE  Biomarker Based Approaches of Targeted Therapy for Lung Cancer Elimination
Author: Anonim
Publsiher: Unknown
Total Pages: 58
Release: 2008
Genre: Electronic Book
ISBN: OCLC:318690821

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Lung cancer is the leading cause of cancer-related death in both men and women in the United States. Chemotherapy has reached its limit in improving the survival of lung cancer patients. Therefore, a different strategy must be waged in the battle against lung cancer. Targeted therapy, a newly emerged therapeutic approach in lung cancer, has succeeded in some cancer types and demonstrated its initial success in the treatment of lung cancer when a class of targeted agents termed epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors, such as gefitinib and erlotinib, improved tumor response rates in patients with advanced nonsmall cell lung cancer (NSCLC), which was strongly correlated to the presence of EGFR mutations in the tumors (Cappuzzo and Hirsch et al., 2004; Cappuzzo and Magrini et al., 2004; Gatzemeier et al., 2004; Herbst and Giaccone et al., 2004; Herbst and Prager et al., 2004; Herbst and Sandler et al., 2004; Lynch et al., 2004; Kobayashi et al., 2005; Miller et al., 2004; Pao et al., 2004; Paez et al., 2004; Shepherd et al., 2004; Shigematsu et al., 2005). This has for the first time demonstrated the importance of selecting patients for individualized targeted therapy in NSCLC.

International Manual of Oncology Practice

International Manual of Oncology Practice
Author: Ramon Andrade De Mello,Giannis Mountzios,Álvaro A. Tavares
Publsiher: Springer Nature
Total Pages: 1162
Release: 2019-10-15
Genre: Medical
ISBN: 9783030162450

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Cancer is a very aggressive disease and currently it has been considered a challenge to oncologists and cancer patients worldwide. Nowadays, several therapeutic strategies had improved toward last decades. Surgery is many times still the best curative treatment, mainly in early stage disease. However, Radiotherapy and chemotherapy acquired a main role in this scenario. Target therapies were introduced for medical oncology practice and are demonstrating a hallmark of a new era in cancer treatment. More recently, immunotherapy has been considered the novel cornerstone in cancer treatment. The 2nd edition of the International Manual of Oncology Practice (iMOP) emerged after the great success of the iMOP 1st edition as a reference for medical oncologists and medical residents in the field. In this edition, several chapters were revised and its addresses from the molecular issues of cancer sciences to the clinical practice in medical oncology. In addition, multiple choice questions and clinical cases were included in the main chapters in order to improve the reader learning. The book focuses systemic treatments in many areas of medical oncology, such as breast cancer, gastrointestinal, thoracic, urological oncology, head and neck tumors, bone tumors, sarcomas and palliative care. The topics herein discussed will provide the readers a step forward in the medical oncology practice understanding and give facilities for help in cancer patient treatments.

Molecular Pathology of Lung Cancer

Molecular Pathology of Lung Cancer
Author: Philip T. Cagle,Timothy Craig Allen,Mary Beth Beasley,Lucian R. Chirieac,Sanja Dacic,Alain C. Borczuk,Keith M. Kerr
Publsiher: Springer Science & Business Media
Total Pages: 216
Release: 2012-06-14
Genre: Medical
ISBN: 9781461431978

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As with other books in the Molecular Pathology Library Series, Molecular Pathology of Lung Cancer bridges the gap between the molecular specialist and the clinical practitioner, including the surgical pathologist who now has a key role in decisions regarding molecular targeted therapy for lung cancer. Molecular Pathology of Lung Cancer provides the latest information and current insights into the molecular basis for lung cancer, including precursor and preinvasive lesions, molecular diagnosis, molecular targeted therapy, molecular prognosis, molecular radiology and related fields for lung cancer generally and for the specific cell types. As many fundamental concepts about lung cancer have undergone revision in only the past few years, this book will likely be the first to comprehensively cover the new molecular pathology of lung cancer. It provides a foundation in this field for pathologists, medical oncologists, radiation oncologists, thoracic surgeons, thoracic radiologists and their trainees, physician assistants, and nursing staff.

Non small Cell Lung Cancer Treatment

Non small Cell Lung Cancer Treatment
Author: Christian Manegold
Publsiher: Unknown
Total Pages: 190
Release: 2010
Genre: Lungs
ISBN: 3837412563

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Lung Cancer

Lung Cancer
Author: Alba Fabiola Costa Torres
Publsiher: BoD – Books on Demand
Total Pages: 204
Release: 2018-10-31
Genre: Medical
ISBN: 9781789843491

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Among the deadliest type of cancers, lung cancer faces several challenges in diagnosis and treatment: late diagnosis and misdiagnosis, inadequate tumor sampling, and resistance development to current therapies, among others. Together with advances in the understanding of molecular features, factors, and mechanisms involved in initiation and tumor progression, important improvements have occurred in diagnostics and therapeutics in the shape of advances in molecular genotyping, procedures for sampling, new potential, and less invasive sources of samples for the diagnosis and development of new targeted therapies. The aim of this book is to provide an exciting read on strategies in the diagnosis and therapy of lung cancer.

Lung Cancer Part I An Issue of Clinics in Chest Medicine

Lung Cancer  Part I  An Issue of Clinics in Chest Medicine
Author: M. Patricia Rivera
Publsiher: Elsevier Health Sciences
Total Pages: 240
Release: 2020-02-04
Genre: Medical
ISBN: 9780323791410

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This issue of Clinics in Chest Medicine, guest-edited by Dr. M. Patricia Rivera, is the first of two issues focused on Lung Cancer. Topics discussed in this issue include but are not limited to: Lung Cancer in the 21st Century; Epidemiology, Etiology, and Prevention; Lung Cancer in Women: A Modern Epidemic; Primary Prevention of Lung Cancer: Tobacco Treatment; The Biology of Lung Cancer: Development of More Effective Methods for Prevention, Diagnosis, and Treatment; Pathology of Lung Cancer; Lung Cancer Screening: Patient Selection and Implementation; The Approach to the Subsolid Nodule; Bronchoscopic Diagnostic Procedures Available to the Pulmonologist; Bronchoscopic Therapeutic Procedures Available to the Pulmonologist; and Biomarkers in Lung Cancer.