SERS for Point of care and Clinical Applications

SERS for Point of care and Clinical Applications
Author: Andrew Fales
Publsiher: Elsevier
Total Pages: 316
Release: 2021-01-15
Genre: Science
ISBN: 0128205482

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SERS for Point-of-care and Clinical Applications focuses on the current uses of Surface-Enhanced Raman Spectroscopy (also known as Surface-Enhanced Raman Scattering) techniques in the clinical and point-of-care settings. In recent years, improvements in detector technology and nanostructure fabrication have expanded the possibilities of using SERS in biomedical applications. These applications are not always immediately evident to newcomers in the field, as Raman and SERS are often introduced as analytical methods for chemical analysis. This book offers a concise introduction to the biomedical applications of SERS for graduate students, scientists, and researchers in all related fields. Readers are first presented with an overview of SERS biomedical applications, and the remaining sections provide in-depth information about point-of-care and clinical applications of SERS using specific examples from the current literature. The first book of its kind to highlight point-of-care applications of SERS Covers the recent biomedical applications of SERS carried out by leaders in the field Includes chapters on SERS probes and labels and label-free uses of SERS

Principles and Clinical Diagnostic Applications of Surface Enhanced Raman Spectroscopy

Principles and Clinical Diagnostic Applications of Surface Enhanced Raman Spectroscopy
Author: Yuling Wang
Publsiher: Elsevier
Total Pages: 464
Release: 2021-09-17
Genre: Science
ISBN: 9780128231982

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Principles and Clinical Diagnostic Applications of Surface-Enhanced Raman Spectroscopy summarizes the principles of surface-enhanced Raman scattering/spectroscopy (SERS) and plasmonic nanomaterials for SERS, with a focus on SERS applications in clinical diagnostics. This book covers the key concepts from the fundamentals, materials, experimental aspects, and applications of SERS in clinical diagnostics with discussions on label-free/direct SERS assay, design and synthesis of SERS nanotags, SERS nanotags for point-of-care diagnostics, microfluidic SERS assay, and in vitro and in vivo sensing and imaging. Written by experts from around the world, this comprehensive volume showcases the recent progress of SERS applications in clinical diagnostics and helps readers understand when and how to use SERS in a clinical setting. Introduces the basics of SERS and suitable nanomaterials for SERS application Gives an overview of the cutting-edge research on SERS applications for clinical diagnosis, including the latest advances in our understanding of underlying principles to enable material design and clinical applications Gradually builds from the fundamental concepts to the applications of SERS for clinical diagnostics

Raman Spectroscopy and Applications

Raman Spectroscopy and Applications
Author: Khan Maaz
Publsiher: BoD – Books on Demand
Total Pages: 364
Release: 2017-02-15
Genre: Science
ISBN: 9789535129073

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Raman spectroscopy has a number of applications in various fields including material science, physics, chemistry, biology, geology, and medicine. This book illustrates necessary insight and guidance in the field of Raman spectroscopy with detailed figures and explanations. This presents deep understanding of new techniques from basic introduction to the advance level for scientists and engineers. The chapters cover all major aspects of Raman spectroscopy and its application in material characterization with special emphasis on both the theoretical and experimental aspects. This book is aimed to provide solid foundation of Raman spectroscopy to the students, scientists, and engineers working in various fields as mentioned above.

Use of Surface Enhanced Raman Spectroscopy for the Detection of Bioactive Lipids

Use of Surface Enhanced Raman Spectroscopy for the Detection of Bioactive Lipids
Author: Christopher M. Ohlhaver
Publsiher: Unknown
Total Pages: 135
Release: 2018
Genre: Electronic Book
ISBN: OCLC:1050953299

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The detection and analysis of lipids in biological matrices for clinical applications poses many challenges, but rapid and reliable detection will prove invaluable for clinical diagnosis. Herein, we report the application of drop-casted Ag nanoplatelets as surface enhanced Raman scattering (SERS) substrates for qualitative detection of 20-hydroxyeicosatetraenoic acid (20-HETE), which is a potential biomarker for diagnosis of hypertensive disorders. Biomarker peaks of 20-HETE can be reliably detected and differentiated from those of the structurally similar lipids (arachidonic acid, eicosapentaenoic acid, and docosahexaenoic acid) commonly found in human blood, even 1 pM concentrations. Additionally, one study mixed 20-HETE with three structurally similar lipids at concentrations several orders of magnitude greater than the target lipid and 20-HETE could still be detected under these conditions. These experiments demonstrate the viability of SERS for the rapid and reliable detection of endogenous bioactive lipids, which has significant clinical impact in enabling point of care diagnostics.

Principles of Surface Enhanced Raman Spectroscopy

Principles of Surface Enhanced Raman Spectroscopy
Author: Eric Le Ru,Pablo Etchegoin
Publsiher: Elsevier
Total Pages: 688
Release: 2008-11-17
Genre: Science
ISBN: 0080931553

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SERS was discovered in the 1970s and has since grown enormously in breadth, depth, and understanding. One of the major characteristics of SERS is its interdisciplinary nature: it lies at the boundary between physics, chemistry, colloid science, plasmonics, nanotechnology, and biology. By their very nature, it is impossible to find a textbook that will summarize the principles needed for SERS of these rather dissimilar and disconnected topics. Although a basic understanding of these topics is necessary for research projects in SERS with all its many aspects and applications, they are seldom touched upon as a coherent unit during most undergraduate studies in physics or chemistry. This book intends to fill this existing gap in the literature. It provides an overview of the underlying principles of SERS, from the fundamental understanding of the effect to its potential applications. It is aimed primarily at newcomers to the field, graduate students, researchers or scientists, attracted by the many applications of SERS and plasmonics or its basic science. The emphasis is on concepts and background material for SERS, such as Raman spectroscopy, the physics of plasmons, or colloid science, all of them introduced within the context of SERS, and from where the more specialized literature can be followed. Represents one of very few books fully dedicated to the topic of surface-enhanced Raman spectroscopy (SERS) Gives a comprehensive summary of the underlying physical concepts around SERS Provides a detailed analysis of plasmons and plasmonics

Next Generation Point of care Biomedical Sensors Technologies for Cancer Diagnosis

Next Generation Point of care Biomedical Sensors Technologies for Cancer Diagnosis
Author: Pranjal Chandra,Yen Nee Tan,Surinder P. Singh
Publsiher: Springer
Total Pages: 396
Release: 2017-12-30
Genre: Medical
ISBN: 9789811047268

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This book presents recent research on cancer detection methods based on nanobiosensors, which offer ultrasensitive point-of-care diagnosis. Several methods for diagnosing cancer have been discovered and many more are currently being developed. Conventional clinical approaches to detecting cancers are based on a biopsy followed by histopathology, or on the use of biomarkers (protein levels or nucleic acid content). Biopsy is the most widely used technique; however, it is an invasive technique and is not always applicable. Furthermore, biomarker-based detection cannot be relied on when the biomarkers are present in an extremely low concentration in the body fluids and in malignant tissues. Thus, in recent years highly sensitive and robust new cancer diagnosis techniques have been developed for clinical application, and may offer an alternative strategy for cancer diagnosis. As such, this book gathers the latest point-of-care cancer diagnostic methods and protocols based on biomedical sensors, microfluidics, and integrated systems engineering. It also discusses recent developments and diagnostics tests that can be conducted outside the laboratory in remote areas. These technologies include electrochemical sensors, paper-based microfluidics, and other kit-based diagnostic methods that can be adapted to bring cancer detection and diagnostics to more remote settings around the globe. Overall, the book provides students, researchers, and clinicians alike a comprehensive overview of interdisciplinary approaches to cancer diagnosis.

Smart Nanodevices for Point of Care Applications

Smart Nanodevices for Point of Care Applications
Author: Suvardhan Kanchi,Rajasekhar Chokkareddy,Mashallah Rezakazemi
Publsiher: CRC Press
Total Pages: 360
Release: 2022-06-23
Genre: Technology & Engineering
ISBN: 9781000593846

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Smart Nanodevices for Point-of-Care Applications examines the latest trends on the capabilities of nanomaterials for point-of-care (PoC) diagnostics and explains how these materials can help to strengthen, miniaturize, and improve the quality of diagnostic devices. A thorough explanation of all-in-one nanosmart devices is included, incorporating all of the applications and fundamentals of these smart devices. This book provides practical information on the following: novel and effective smart materials, better-quality health management, effective management of a disease, potential point-of-care devices, and mobile nanosensors. Additional Features Includes in-depth research based collation of the latest trends of smart devices Provides practical information on all-in-one nanosmart devices Explains how nanomaterials can help to strengthen and improve the quality of diagnostic devices Emphasizes the development of smart nanodevices, especially the miniaturization aspect

Surface Enhanced Raman Spectroscopy Biosensing and Diagnostic Technique for Healthcare Applications

Surface Enhanced Raman Spectroscopy  Biosensing and Diagnostic Technique for Healthcare Applications
Author: Swati Jain
Publsiher: Bentham Science Publishers
Total Pages: 265
Release: 2021-12-28
Genre: Science
ISBN: 9789815039122

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Surface enhanced Raman spectroscopy (SERS) is a technique applied in multidisciplinary research. Its use has tremendously grown in the last 40 years owing to improved nanofabrication, biomolecules extraction and sensitive signal acquisition techniques. This book focuses on the underlying principles of SERS by emphasizing on basic concepts and background information about the subject. Chapters explain the physics of Raman spectroscopy while also indicating its relevance to designing protocols and methodologies for biosensing and imaging. The book gives updated and recent details on colloids and nanostructures, their fabrication, surface engineering and immobilization methods, all in context to SERS based biosensing. Key Features: - Covers basic knowledge and new research about surface enhanced Raman spectroscopy (SERS) - Provides a complete framework on SERS based biosensing with concise chapters - Focuses on different active molecules critical to SERS and associated developed nanoassemblies - Presents information about ongoing research on SERS imaging applications - Highlights bottlenecks of SERS technique in biosensing - Includes references for further reading This book serves as a reference book for researchers and academicians and will also provide a reasonable understanding on the topic of SERS to newcomers irrespective of their background in a simple manner. The book is of interest to all readers within the scientific community involved with Raman spectroscopy, including chemists, physicists, biologists, material scientists as well as biomedical engineers.

Nanomaterials in Diagnostic Tools and Devices

Nanomaterials in Diagnostic Tools and Devices
Author: Suvardhan Kanchi,D. Sharma
Publsiher: Elsevier
Total Pages: 618
Release: 2020-06-04
Genre: Technology & Engineering
ISBN: 9780128179246

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Nanomaterials in Diagnostic Tools and Devices provides a complete overview of the significance of nanomaterials in fabricating selective and performance enhanced nanodevices. It is an interdisciplinary reference that includes contributing subjects from nanomaterials, biosensors, materials science, biomedical instrumentation and medicinal chemistry. This book is authored by experts in the field of nanomaterial synthesis, modeling, and biosensor applications, and provides insight to readers working in various science fields on the latest advancements in smart and miniaturized nanodevices. These devices enable convenient real-time diagnosis of diseases at clinics rather than laboratories, and include implantable devices that cause less irritation and have improved functionality. Research in the field of nanomaterials is growing rapidly, creating a significant impact across different science disciplines and nanotechnology industries. This synthesis and modeling of nanomaterials has led to many technology breakthroughs and applications, especially in medical science. Provides a distinctive platform for the latest trends in the synthesis of smart nanomaterials for nanodevices in disease diagnostics Presents a broad range of advancements and applications of lateral-flow nanostrip for point-of-care applications Examines smart-phone based nanodevices for field-based diagnosis with accurate information Comprises more than 70 figures and illustrations that will help readers visualize and easily understand the role of nanodevices in the field of nanomedicine Serves as an ideal reference for those studying smart nanomaterials, biosensors, and nanodevices for real-time and in-situ clinical diagnosis and drug delivery

Surface Enhanced Vibrational Spectroscopy

Surface Enhanced Vibrational Spectroscopy
Author: Ricardo Aroca
Publsiher: John Wiley & Sons
Total Pages: 260
Release: 2006-05-01
Genre: Science
ISBN: 047003565X

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Surface Enhanced Vibrational Spectroscopy (SEVS) has reached maturity as an analytical technique, but until now there has been no single work that describes the theory and experiments of SEVS. This book combines the two important techniques of surface-enhanced Raman scattering (SERS) and surface-enhanced infrared (SEIR) into one text that serves as the definitive resource on SEVS. Discusses both the theory and the applications of SEVS and provides an up-to-date study of the state of the art Offers interpretations of SEVS spectra for practicing analysts Discusses interpretation of SEVS spectra, which can often be very different to the non-enhanced spectrum - aids the practicing analyst

Nanobiomaterials

Nanobiomaterials
Author: Xiumei Wang,Murugan Ramalingam,Xiangdong Kong,Lingyun Zhao
Publsiher: John Wiley & Sons
Total Pages: 238
Release: 2017-11-21
Genre: Technology & Engineering
ISBN: 9783527698639

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Written by an international team of editors and contributors from renowned universities and institutes, this book addresses the latest research in the field of nanobiomaterials, covering nanotechnologies for their fabrication, developments in biomedical applications, and the challenges of biosafety in clinic uses. Clearly structured, the volume defines the scope and classification of the field, resulting in a broad overview from fundamental principles to current technological advances, and from materials synthesis to biomedical applications along with future trends.

The Detection of Biomarkers

The Detection of Biomarkers
Author: Sibel A. Ozkan,Nurgul K. Bakirhan,Fariba Mollaraosouli
Publsiher: Academic Press
Total Pages: 614
Release: 2021-12-05
Genre: Medical
ISBN: 9780128230756

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Reliable, precise and accurate detection and analysis of biomarkers remains a significant challenge for clinical researchers. Methods for the detection of biomarkers are rather complex, requiring pre-treatment steps before analysis can take place. Moreover, comparing various biomarker assays and tracing research progress in this area systematically is a challenge for researchers. The Detection of Biomarkers presents developments in biomarker detection, including methods tools and strategies, biosensor design, materials, and applications. The book presents methods, materials and procedures that are simple, precise, sensitive, selective, fast and economical, and therefore highly practical for use in clinical research scenarios. This volume situates biomarker detection in its research context and sets out future prospects for the area. Its 20 chapters offer a comprehensive coverage of biomarkers, including progress on nanotechnology, biosensor types, synthesis, immobilization, and applications in various fields. The book also demonstrates, for students, how to synthesize and immobilize biosensors for biomarker assay. It offers researchers real alternative and innovative ways to think about the field of biomarker detection, increasing the reliability, precision and accuracy of biomarker detection. Locates biomarker detection in its research context, setting out present and future prospects Allows clinical researchers to compare various biomarker assays systematically Presents new methods, materials and procedures that are simple, precise, sensitive, selective, fast and economical Gives innovative biomarker assays that are viable alternatives to current complex methods Helps clinical researchers who need reliable, precise and accurate biomarker detection methods

Surface Enhanced Raman Scattering

Surface Enhanced Raman Scattering
Author: Katrin Kneipp,Martin Moskovits,Harald Kneipp
Publsiher: Springer Science & Business Media
Total Pages: 466
Release: 2006-06-21
Genre: Science
ISBN: 9783540335672

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Almost 30 years after the first reports on surface-enhanced Raman signals, the phenomenon of surface-enhanced Raman scattering (SERS) is now well established. SERS gained particular interest after single-molecule Raman spectroscopy had been demonstrated. This book summarizes and discusses present theoretical approaches that explain the phenomenon of SERS and reports on new and exciting experiments and applications of the fascinating spectroscopic effect.

Silver Micro Nanoparticles

Silver Micro Nanoparticles
Author: Samir Kumar,Prabhat Kumar,Chandra Shakher Pathak
Publsiher: BoD – Books on Demand
Total Pages: 266
Release: 2021-09-15
Genre: Technology & Engineering
ISBN: 9781839686597

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This book describes the different methodologies for producing and synthesizing silver nanoparticles (AgNPs) of various shapes and sizes. It also provides an in-depth understanding of the new methods for characterizing and modifying the properties of AgNPs as well as their properties and applications in various fields. This book is a useful resource for a wide range of readers, including scientists, engineers, doctoral and postdoctoral fellows, and scientific professionals working in specialized fields such as medicine, nanotechnology, spectroscopy, analytical chemistry diagnostics, and plasmonics.

Nanotechnology in Cancer Management

Nanotechnology in Cancer Management
Author: Kamil Reza Khondakar,Ajeet Kaushik
Publsiher: Elsevier
Total Pages: 252
Release: 2021-05-18
Genre: Technology & Engineering
ISBN: 9780128181553

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Nanotechnology in Cancer Management: Precise Diagnostics toward Personalized Health Care provides a well-focused and comprehensive overview of technologies involved in early stage cancer diagnostics via the detection of various cancer biomarkers, both in-vitro and in-vivo. The book briefly describes the advancement in cancer biomarker research relating to cancer diagnostics, covering fundamental aspects of various techniques, especially transduction methodologies, such as electrochemical, optical, magnetic, etc. In addition, it describes approaches on how to make options cost-effective, scalable for clinical application, and user-friendly. Advancements in technology related to device miniaturization, performance improvement and point-of-care applications round out discussions. Final sections cover future challenges, the prospects of various techniques, and how the introduction of nanotechnology in cancer management in a personalized manner is useful. Includes smart sensing materials such as smart electro-active nanomaterials, sensitive transducers development, nano-enabled advanced imaging, miniaturized analytical system, and device integration and interfacing for point-of-care applications Describes each component involved in the development of an efficient cancer diagnostics system Focuses on fundamental and applied concepts of the technologies, along with the related mechanisms proposed for diagnostics of cancer Enhances fundamental understandings of the concepts and development of nanotechnology based analytical tools and novel techniques for early stage cancer diagnostics and management