Spontaneous Pathology of the Laboratory Non Human Primate

Spontaneous Pathology of the Laboratory Non Human Primate
Author: Alys E. Bradley,Jennifer Chilton
Publsiher: Academic Press
Total Pages: 575
Release: 2020-11-01
Genre: Science
ISBN: 9780128130896

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Spontaneous Pathology of the Laboratory Nonhuman Primate serves as a "go to" resource for all pathologists working on primates in safety assessment studies. In addition, it helps diagnostic veterinary pathologists rule out spontaneous non-clinical disease pathologies when assigning cause of death to species in zoological collections. Primate species included are rhesus, cynomolgus macaques and marmosets. Multi-authored chapters are arranged by organ system, thus providing the necessary information for continued research. Pathologists often face a lack of suitable reference materials or historical data to determine if pathologic changes they are observing in monkeys are spontaneous or a consequence of other treatments or factors. Contains color illustrations that depict the most common lesions to augment descriptions Covers descriptions that are compliant with the International Harmonization of Nomenclature and Diagnostic Criteria (INHAND) guidelines set forth by the Society of Toxicologic Pathology (STP) Provides pathologists with common terms that are compliant with the FDA’s Standard for Exchange of Nonclinical Data (SEND) guidelines

Nonhuman Primates

Nonhuman Primates
Author: Thomas C. Jones,Ulrich Mohr,Ronald D. Hunt
Publsiher: Springer Science & Business Media
Total Pages: 248
Release: 2012-12-06
Genre: Medical
ISBN: 9783642849244

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The International Life Sciences Institute (ILSI) was estab lished in 1978 to stimulate and support scientific research and educational programs related to nutrition, toxicology, and food safety, and to encourage cooperation in these programs among scientists in universities, industry, and government agencies to assist in the resolution of health and safety issues. To supplement and enhance these efforts, ILSI has made a major commitment to supporting programs to harmonize toxicologic testing, to advance a more uniform interpreta tion of bioassay results worldwide, to promote a common understanding of lesion classifications, and to encourage wide discussion of these topics among scientists. The M on ographs on the Pathology of Laboratory Animals are de signed to facilitate communication among those involved in the safety testing of foods, drugs, and chemicals. The complete set will cover all organ systems and is intended for use by pathologists, toxicologists, and others con cerned with evaluating toxicity and carcinogenicity stud ies. The international nature of the project - as reflected in the composition of the editorial board and the diversity of the authors and editors - strengthens our expectations that understanding and cooperation will be improved worldwide through the series. Alex Malaspina President International Life Sciences Institute Preface This book on nonhuman primate pathology is the 12th volume of a set of monographs prepared under the sponsorship of the International Life Sciences Institute (ILSI).

The Baboon in Biomedical Research

The Baboon in Biomedical Research
Author: John L. VandeBerg,Sarah Williams-Blangero,Suzette D. Tardif
Publsiher: Springer Science & Business Media
Total Pages: 392
Release: 2009-06-04
Genre: Science
ISBN: 0387759913

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Nonhuman primates have played critical roles in biomedical research, and they are among the few animals whose use in research continues to increase. The scienti?c value of nonhuman primates derives from their close phylogenetic proximity to man and their consequent anatomic, physiologic, and genetic similarities to man. Only nonhuman primates can provide adequate models for many complex physiological and disease processes of humans. The baboon is a relative newcomer to the repertoire of nonhuman primates used in biomedical research. However, in less than 50 years since its ?rst use in the U. S. , it has become one of the most popular laboratory primate species. It is larger than the other widely used monkey species, making it advantageous for many types of experiments and technological developments. It is extraordinarily hardy and highly fecund in captivity. It closely resembles humans in a variety of physiological and disease processes, such as cholesterol metabolism, early stages of atherosclerosis, and alcoholic liver disease. Its chromosomes closely resemble those of humans, and many genes of the two species lie in the same chromosomal order. Among all primates, baboons are the most widely used models for the genetics of susceptibility to complex diseases and they are the ?rst nonhuman primate for which a framework genetic linkage map was established. In addition, the baboon genome is currently being sequenced, and as a result the utility of this species for biomedical research will be dramatically increased.

Primates

Primates
Author: Kurt Benirschke
Publsiher: Springer Science & Business Media
Total Pages: 1044
Release: 2012-12-06
Genre: Science
ISBN: 9781461249184

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This conference represents the first time in my life when I felt it was a misfor tune, rather than a major cause of my happiness, that I do conservation work in New Guinea. Yes, it is true that New Guinea is a fascinating microcosm, it has fascinating birds and people, and it has large expanses of undisturbed rainforest. In the course of my work there, helping the Indonesian government and World Wildlife Fund set up a comprehensive national park system, I have been able to study animals in areas without any human population. But New Guinea has one serious drawback: it has no primates, except for humans. Thus, I come to this conference on primate conservation as an underprivileged and emotionally deprived observer, rather than as an involved participant. Nevertheless, it is easy for anyone to become interested in primate conserva tion. The public cares about primates. More specifically, to state things more realistically, many people care some of the time about some primates. Primates are rivaled only by birds, pandas, and the big cats in their public appeal. For some other groups of animals, the best we can say is that few people care about them, infrequently. For most groups of animals, no one cares about them, ever.

Nonhuman Primates I

Nonhuman Primates I
Author: Thomas C. Jones,Ulrich Mohr,Ronald D. Hunt
Publsiher: Springer Science & Business Media
Total Pages: 221
Release: 2012-12-06
Genre: Medical
ISBN: 9783642849060

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The International Life Sciences Institute (ILSI) was estab lished in 1978 to stimulate and support scientific research and educational programs related to nutrition, toxicology, and food safety, and to encourage cooperation in these programs among scientists in universities, industry, and government agencies to assist in the resolution of health and safety issues. To supplement and enhance these efforts, ILSI has made a major commitment to supporting programs to harmonize toxicologic testing, to advance a more uniform interpreta tion of bioassay results worldwide, to promote a common understanding of lesion classifications, and to encourage wide discussion of these topics among scientists. The Mo nographs on the Pathology of Laboratory Animals are de signed to facilitate communication among those involved in the safety testing of foods, drugs, and chemicals. The complete set will cover all organ systems and is intended for use by pathologists, toxicologists, and others con cerned with evaluating toxicity and carcinogenicity stu dies. The international nature of the project - as reflected in the composition of the editorial board and the diversity of the authors and editors -strengthens our expectations that understanding and cooperation will be improved worldwide through the series. Alex Malaspina President International Life Sciences Institute Preface This book, on Nonhuman Primates, is the eleventh volume of a set pre pared under the sponsorship of the International Life Sciences Institute (ILSI).

Pathology of the Kidney

Pathology of the Kidney
Author: Robert H. Heptinstall
Publsiher: Unknown
Total Pages: 656
Release: 1983
Genre: Kidneys
ISBN: NWU:35558000547576

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The Nonhuman Primate in Nonclinical Drug Development and Safety Assessment

The Nonhuman Primate in Nonclinical Drug Development and Safety Assessment
Author: Joerg Bluemel,Sven Korte,Emanuel Schenck,Gerhard Weinbauer
Publsiher: Academic Press
Total Pages: 716
Release: 2015-03-13
Genre: Medical
ISBN: 9780124171466

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The Nonhuman Primate in Drug Development and Safety Assessment is a valuable reference dedicated to compiling the latest research on nonhuman primate models in nonclinical safety assessment, regulatory toxicity testing and translational science. By covering important topics such as study planning and conduct, inter-species genetic drift, pathophysiology, animal welfare legislation, safety assessment of biologics and small molecules, immunotoxicology and much more, this book provides scientific and technical insights to help you safely and successfully use nonhuman primates in pharmaceutical toxicity testing. A comprehensive yet practical guide, this book is intended for new researchers or practicing toxicologists, toxicologic pathologists and pharmaceutical scientists working with nonhuman primates, as well as graduate students preparing for careers in this area. Covers important topics such as species selection, study design, experimental methodologies, animal welfare and the 3Rs (Replace, Refine and Reduce), social housing, regulatory guidelines, comparative physiology, reproductive biology, genetic polymorphisms and more Includes practical examples on techniques and methods to guide your daily practice Offers a companion website with high-quality color illustrations, reference values for safety assessment and additional practical information such as study design considerations, techniques and procedures and dosing and sampling volumes

Spontaneous Pathology of the Laboratory Rabbit

Spontaneous Pathology of the Laboratory Rabbit
Author: Alys Bradley
Publsiher: Academic Press
Total Pages: 575
Release: 2023-04-15
Genre: Science
ISBN: 0128225289

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Spontaneous Pathology of the Laboratory Rabbit serves as a "go to” text for all pathologists working on laboratory rabbits in safety assessment studies. The book helps diagnostic veterinary pathologists rule out spontaneous non-clinical disease pathology when assigning cause of death to these animals which are also kept as domestic pets. The book provides a comprehensive text on the spontaneous pathology seen in common laboratory rabbit strains. This is the first book collating information on all organ systems in these strains. Consist of multi-author chapters arranged by organ systems Presents color illustrations that depict the most common lesions to augment the descriptions Provides pathologists with common terms that are compliant with the FDA's Standard for Exchange of Nonclinical Data (SEND) guidelines Gives references for recommended tissue trimming planes