The Design and Development of Novel Drugs and Vaccines

The Design and Development of Novel Drugs and Vaccines
Author: Tarun Kumar Bhatt,Surendra Nimesh
Publsiher: Academic Press
Total Pages: 308
Release: 2021-01-21
Genre: Business & Economics
ISBN: 9780128214756

Download The Design and Development of Novel Drugs and Vaccines Book in PDF, Epub and Kindle

The Design and Development of Novel Drugs and Vaccines: Principles and Protocols presents both in silico methods and experimental protocols for vaccine and drug design and development, critically reviewing the most current research and emphasizing approaches and technologies that accelerate and lower the cost of product development. Sections review the technologies and approaches used to identify, characterize and establish a protein as a new drug and vaccine target, cover several molecular methods for in vitro studies of the desired target, and present various physiological parameters for in vivo studies. The book includes preclinical trials and research, along with information on FDA approval. Covers both in silico methods and experimental protocols for vaccine and drug development in a single, accessible volume Offers a holistic accounting of how developments in bioinformatics and large experimental datasets can be used in the development of vaccines and drugs Shows researchers the entire gamut of current therapies, ranging from computational inputs to animal studies Reviews the most current, cutting-edge research available on vaccine and drug design and development

Nonclinical Development of Novel Biologics Biosimilars Vaccines and Specialty Biologics

Nonclinical Development of Novel Biologics  Biosimilars  Vaccines and Specialty Biologics
Author: Lisa Plitnick,Danuta Herzyk
Publsiher: Academic Press
Total Pages: 432
Release: 2013-06-27
Genre: Medical
ISBN: 9780123948236

Download Nonclinical Development of Novel Biologics Biosimilars Vaccines and Specialty Biologics Book in PDF, Epub and Kindle

Nonclinical Development of Novel Biologics, Biosimilars, Vaccines and Specialty Biologics is a complete reference devoted to the nonclinical safety assessment of novel biopharmaceuticals, biosimilars, vaccines, cell and gene therapies and blood products. This book compares and contrasts these types of biologics with one another and with small molecule drugs, while incorporating the most current and essential international regulatory documents. Each section discusses a different type of biologic, as well as early characterization strategies, principles of study design, preclinical pharmacokinetics and pharmacodynamics and preclinical assays. An edited book that is authored by leading experts in the field, this comprehensive reference provides critical insights to all researchers involved in early through late stage biologics. Provides in-depth coverage of the process of nonclinical safety assessment and comprehensive reviews of each type of biopharmaceutical Contains the most pertinent international regulatory guidance documents for nonclinical evaluation Covers early de-risking strategies and designs of safety assessment programs for novel biopharmaceuticals and vaccines, as well as follow-on biologics or "biosimilars" A multi-authored book with chapters written by qualified experts in their respective fields

Parasites Molecular Biology Drug and Vaccine Design

Parasites  Molecular Biology  Drug and Vaccine Design
Author: Nina Agabian,Anthony Cerami
Publsiher: Unknown
Total Pages: 504
Release: 1990
Genre: Antigènes parasitaires - Congrès
ISBN: UOM:39015017994354

Download Parasites Molecular Biology Drug and Vaccine Design Book in PDF, Epub and Kindle

This wide-ranging collection of edited papers examines the many mechanisms that allow parasites to survive and interact in a host environment. The research explains how a more knowledgeable understanding of host-parasite interactions aids in the development of unique strategies for vaccine design and applied research in clinical diagnostics and therapeutics. Divided into five parts, the text covers gene expression during parasite differentiation and development; the potential for molecular genetics in parasite systems; molecules of the parasite membrane; molecular modeling and parasite drug design; and vaccines.

Novel Approaches and Strategies for Biologics Vaccines and Cancer Therapies

Novel Approaches and Strategies for Biologics  Vaccines and Cancer Therapies
Author: Manmohan Singh,Maya Salnikova
Publsiher: Academic Press
Total Pages: 520
Release: 2014-12-30
Genre: Medical
ISBN: 9780124166615

Download Novel Approaches and Strategies for Biologics Vaccines and Cancer Therapies Book in PDF, Epub and Kindle

Novel Approaches and Strategies for Biologics, Vaccines and Cancer Therapies takes a look at the current strategies, successes and challenges involved with the development of novel formulations of biologics, vaccines and cancer therapy. This thorough reference on the latest trends in the development of diverse modalities will appeal to a broad community of scientists, students and clinicians. Written by leading authors across academia and industry, this book covers important topics such as unique drug delivery devices, non-parenteral delivery trends, novel approaches to the treatment of cancer, immunotherapy and more. It includes real-world cases and examples which highlight formulations with therapeutic proteins, monoclonal antibodies, peptides and biobetters, as well as cases on novel vaccines formulations including evolving pathogens, novel modalities of vaccines, universal vaccines. This book is a thorough and useful resource on the development of novel biologics, vaccines and cancer therapies. Provides strategies for the development of safe and efficacious novel formulations for various modalities of biologics, vaccines and for cancer therapy Highlights novel cases from current clinical trials as well as marketed products Reviews overall successes and challenges in the development of novel formulations, including new molecular targets for the treatment of diseases, design of target-specific therapies, regulatory considerations, individualized therapies

Practical Aspects of Vaccine Development

Practical Aspects of Vaccine Development
Author: Parag Kolhe,Satoshi Ohtake
Publsiher: Elsevier
Total Pages: 386
Release: 2021-09-24
Genre: Business & Economics
ISBN: 9780128143575

Download Practical Aspects of Vaccine Development Book in PDF, Epub and Kindle

Formulation, Development and Manufacturing of Vaccines: The Practical Aspects provides an industry perspective on vaccine product development and manufacture that covers their formulation development, manufacture and delivery/in-use considerations of vaccine production. With the increasing complexity of vaccine products in development, there is a need for a comprehensive review of the current state of the industry and its challenges. While formulation scientists working in biotherapeutic development may be familiar with proteins, vaccines present unique challenges, including the wide range of vaccine components that may comprise proteins, polysaccharides, protein-polysaccharide conjugates, adjuvants, etc. and the varying stability and behavior of solution- and suspension-based systems. This book is an essential resource for formulation scientists, researchers in vaccine development throughout medical and life sciences, and advanced students. Includes formulation considerations for various vaccine types, including proteins, polysaccharides, conjugates and live vaccines Considers process development for solution, suspension and lyophilized products Explores the future potential of vaccines, including multi-component vaccines and novel delivery mechanisms/devices

Immunotherapy A Novel Facet of Modern Therapeutics

Immunotherapy     A Novel Facet of Modern Therapeutics
Author: Sujata P. Sawarkar,Vandana S. Nikam,Shariq Syed
Publsiher: Springer Nature
Total Pages: 262
Release: 2020-12-16
Genre: Medical
ISBN: 9789811590382

Download Immunotherapy A Novel Facet of Modern Therapeutics Book in PDF, Epub and Kindle

This book illustrates the significance and relevance of immunotherapy in modern-day therapeutics. Focusing on the application of immunotherapy in oncology, neurodegenerative and autoimmune diseases, it discusses the drug delivery systems, and pre-clinical and clinical methodologies for immunotherapy-based drugs. It also comprehensively reviews various aspects of immunotherapy, such as regulatory affairs, quality control, safety, and pharmacovigilance. Further, the book discusses the in vitro validation of therapeutic strategies prior to patient application and management of immunotherapy-related side effects and presents case studies demonstrating the design and development (pre-clinical to clinical) of immunotherapy for various diseases. It also describes various design considerations and the scale-up synthesis of immunotherapeutics and screening methods. Lastly, it explores the important aspect of cost-effectiveness and rational immunotherapy strategies.

Improving and Accelerating Therapeutic Development for Nervous System Disorders

Improving and Accelerating Therapeutic Development for Nervous System Disorders
Author: Institute of Medicine,Board on Health Sciences Policy,Forum on Neuroscience and Nervous System Disorders
Publsiher: National Academies Press
Total Pages: 118
Release: 2014-02-06
Genre: Medical
ISBN: 9780309292498

Download Improving and Accelerating Therapeutic Development for Nervous System Disorders Book in PDF, Epub and Kindle

Improving and Accelerating Therapeutic Development for Nervous System Disorders is the summary of a workshop convened by the IOM Forum on Neuroscience and Nervous System Disorders to examine opportunities to accelerate early phases of drug development for nervous system drug discovery. Workshop participants discussed challenges in neuroscience research for enabling faster entry of potential treatments into first-in-human trials, explored how new and emerging tools and technologies may improve the efficiency of research, and considered mechanisms to facilitate a more effective and efficient development pipeline. There are several challenges to the current drug development pipeline for nervous system disorders. The fundamental etiology and pathophysiology of many nervous system disorders are unknown and the brain is inaccessible to study, making it difficult to develop accurate models. Patient heterogeneity is high, disease pathology can occur years to decades before becoming clinically apparent, and diagnostic and treatment biomarkers are lacking. In addition, the lack of validated targets, limitations related to the predictive validity of animal models - the extent to which the model predicts clinical efficacy - and regulatory barriers can also impede translation and drug development for nervous system disorders. Improving and Accelerating Therapeutic Development for Nervous System Disorders identifies avenues for moving directly from cellular models to human trials, minimizing the need for animal models to test efficacy, and discusses the potential benefits and risks of such an approach. This report is a timely discussion of opportunities to improve early drug development with a focus toward preclinical trials.

Drug Development for Malaria

Drug Development for Malaria
Author: Pravin Kendrekar
Publsiher: John Wiley & Sons
Total Pages: 404
Release: 2022-11-07
Genre: Medical
ISBN: 9783527348602

Download Drug Development for Malaria Book in PDF, Epub and Kindle

Drug Development for Malaria Provides readers with first-hand advice for the development of novel antimalarial drugs This book provides a systematic overview of antimalarial drug development and presents a wealth of data and insight from drug developers across three continents, including many from countries where the disease is endemic. Throughout, the contributions have been written with the drug developer in mind, highlighting challenges but also opportunities for the successful development of effective antimalarial drugs. Case studies and method-oriented chapters provide an abundance of practical first-hand advice on how to successfully develop an antimalarial drug. Key topics covered in the book include: The performance of current drugs and therapies, the influence of formulation and targeted delivery, and strategies to overcome drug resistance. Technologies and approaches for development of novel drugs, such as assays, computer-aided drug design, known and potential drug targets, and natural sources for novel antimalarial compounds Vaccination as an alternative to drug therapy For chemists and other professionals working in industries related to medicine and pharmaceuticals, this book provides a completely comprehensive overview of the current state of novel antimalarial drugs and how they can be developed in an efficient and cost-effective manner.

Novel Strategies in the Design and Production of Vaccines

Novel Strategies in the Design and Production of Vaccines
Author: Sara Cohen,Avigdor Shafferman
Publsiher: Springer Science & Business Media
Total Pages: 198
Release: 2013-06-29
Genre: Medical
ISBN: 9781489913821

Download Novel Strategies in the Design and Production of Vaccines Book in PDF, Epub and Kindle

Vaccination is one of the most efficient and cost effective methods of promoting human health and has been in clinical use for at least 200 years. Nevertheless, infectious diseases continue to constitute a constant threat to the well being of humanity. Common pathogens, once believed to be under control, acquire increased virulence and resistance to drugs, while exotic microorganisms emerged from hidden reservoirs to cause yet incurable diseases in humans. These changes, together with epidemic outbreaks related to political and socio-economic instabilities, increase the needs for the development of new, advanced vaccines. In this volume, devoted to the proceedings of the 39th OHOLO Conference, we present some of the recent strategies for the design and production of novel vaccines. The advent of recombinant DNA technology has stimulated the production of several subunit vaccines. In spite of the obvious advantages to this approach, the limited immuno genicity of many subunit candidates has hindered their development. Strategies to enhance the immunogenicity of subunit vaccines is therefore critical. Several approaches toward this goal, including design of novel adjuvants and delivery systems as well as design of advantageous carriers, are presented here. Among the carriers evaluated here are polypep tides (flagellin, HBV core antigen, J3-galactosidase), attenuated virions (Vaccinia, Sindbis), and nonpathogenic licensed bacteria (Salmonella).

Post Genomic Approaches in Drug and Vaccine Development

Post Genomic Approaches in Drug and Vaccine Development
Author: Kishore R. Sakharkar,Meena K. Sakharkar ,Ramesh Chandra
Publsiher: River Publishers
Total Pages: 450
Release: 2015-04-11
Genre: Medical
ISBN: 9788793102842

Download Post Genomic Approaches in Drug and Vaccine Development Book in PDF, Epub and Kindle

Over the past decade, genome sequencing projects and the associated efforts have facilitated the discovery of several novel disease targets and the approval of several innovative drugs. To further exploit this data for human health and disease, there is a need to understand the genome data itself in detail, discover novel targets, understand their role in physiological pathways and associated diseases, with the aim to translate these discoveries to clinical and preventive medicine. It is equally important to understand the labors and limitations in integrating clinical phenotypes with genomic, transcriptomic, proteomic and metabolomic approaches. This book focuses on some key advances in the field. Technical topics discussed in the book include: Drug discoveryTarget identification and prioritizationHypothesis driven multi-target drug designGenomics in vaccine developmentGene regulatory networks Vaccine design and developmentPrediction of drug side effects in silico

Biomedical Index to PHS supported Research

Biomedical Index to PHS supported Research
Author: Anonim
Publsiher: Unknown
Total Pages: 135
Release: 1991
Genre: Medicine
ISBN: UOM:39015020571777

Download Biomedical Index to PHS supported Research Book in PDF, Epub and Kindle

Vaccine Design

Vaccine Design
Author: Rino Rappuoli,Fabio Bagnoli
Publsiher: Caister Academic Press
Total Pages: 380
Release: 2011
Genre: Medical
ISBN: 1904455743

Download Vaccine Design Book in PDF, Epub and Kindle

In this book, expert international authors critically review the current cutting-edge research in vaccine design and development. Particular emphasis is given to new approaches and technologies.

Nutrition and Disease

Nutrition and Disease
Author: Kenneth Lundstrom
Publsiher: Cambridge Scholars Publishing
Total Pages: 180
Release: 2020-02-24
Genre: Medical
ISBN: 9781527547537

Download Nutrition and Disease Book in PDF, Epub and Kindle

Nutrition is an essential part of life. It affects our health and can be applied in the prevention and treatment of disease. Substantial interventions in dietary intake and lifestyle changes have been demonstrated to cause significant decrease in disease risk in in the general population and also in patients suffering from various diseases. Traditional plant-based diets and medicines have received much attention as an alternative to modern science-based drugs, while recent technology development in bioinformatics, genomics, and proteomics has provided a better understanding of plant-based drugs, improved quality assurance and allowed the acceleration of clinical trials to bridge the gap with Western medicine. Moreover, research in nutrigenomics and epigenomics has further enhanced the knowledge of the association between nutrition and disease. The book deals with the concerns of the future well-being of our planet, the health of the global human population related to the worldwide obesity epidemic, the issues related to sustainable food production, and the need for a switch to a healthier, more plant-based diet.

Design and Development of New Nanocarriers

Design and Development of New Nanocarriers
Author: Alexandru Mihai Grumezescu
Publsiher: William Andrew
Total Pages: 766
Release: 2017-12-12
Genre: Science
ISBN: 9780128136287

Download Design and Development of New Nanocarriers Book in PDF, Epub and Kindle

Design and Development of New Nanocarriers focuses on the design and development of new nanocarriers used in pharmaceutical applications that have emerged in recent years. In particular, the pharmaceutical uses of microfluidic techniques, supramolecular design of nanocapsules, smart hydrogels, polymeric micelles, exosomes and metal nanoparticles are discussed in detail. Written by a diverse group of international researchers, this book is a valuable reference resource for those working in both biomaterials science and the pharmaceutical industry. Shows how nanomanufacturing techniques can help to create more effective, cheaper pharmaceutical products Explores how nanofabrication techniques developed in the lab have been translated to commercial applications in recent years Explains safety and regulatory aspects of the use of nanomanufacturing processes in the pharmaceutical industry

Gene therapy

Gene therapy
Author: Surendra Nimesh
Publsiher: Elsevier
Total Pages: 380
Release: 2013-10-31
Genre: Science
ISBN: 9781908818645

Download Gene therapy Book in PDF, Epub and Kindle

Gene therapy is emerging as a new class of therapeutics for the treatment of inherited and acquired diseases. However, poor cellular uptake and instability of DNA in the physiological milieu limits its therapeutic potential, hence a vector which can protect and efficiently transport DNA to the target cells must be developed. Nanotechnology-based non-viral vectors have been proposed as potential candidates. Various polymeric nanoparticles have been shown to be suitable, with high cellular uptake efficiencies and reduced cytotoxicity. These delivery vectors form condensed complexes with DNA which result in shielding against enzymatic degradation and enhanced cellular targeting. Advantages including easy manipulatibility, high stability, low cost and high payload, mean that nanoparticles from various polymers have been exploited. Gene therapy gives a systematic account of the many aspects of nanotechnology mediated gene therapy, from the preparation of nanoparticles to physicochemical characterization, and follows with applications in in vitro and in vivo models. This book emphasizes the various aspects of nanotechnology-based gene therapy, with initial chapters detailing the tools and techniques available for preparation and in vitro and in vivo characterization of nanoparticles. Later chapters provide exhaustive details on polymeric systems employed for gene therapy. Provides an overview of nanotechnology applications in gene therapy, from preparation of nanoparticles to in vitro and in vivo studies Details the tools and techniques available for preparation, characterization and in vitro and in vivo study of nanoparticles Details the limitations of nanoparticle-mediated gene therapy and proposes ways in which they may be overcome