The Management of Scientific Integrity within Academic Medical Centers

The Management of Scientific Integrity within Academic Medical Centers
Author: Peter Snyder,Linda C. Mayes,William E. Smith
Publsiher: Academic Press
Total Pages: 224
Release: 2015-01-06
Genre: Science
ISBN: 9780124059290

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The Management of Scientific Integrity within Academic Medical Centers discusses the impact scientific misconduct has in eight complex case studies. Authors look at multifaceted mixtures of improper behavior, poor communication, cultural issues, adverse medical/health issues, interpersonal problems and misunderstandings to illustrate the challenge of identifying and managing what went wrong and how current policies have led to the establishment of quasi legal processes within academic institutions. The book reviews the current global regulations and concludes with a section authored by a US federal court judge who provides his perspective on the adequacy of current regulations and policies. Shows how complex most scientific integrity cases are, and how little is clear cut in the adjunction of each Discusses how timely and important scientific misconduct is, and its impact on science at large Reviews the current regulations and policies that guide how we manage scientific integrity Examines this complexity in 8 anonymous case studies Concludes with a section authored by an expertly qualified federal court judge

The Management of Scientific Integrity Within Academic Medical Centers

The Management of Scientific Integrity Within Academic Medical Centers
Author: Peter Snyder,Linda C. Mayes,William E. Smith
Publsiher: Academic Press
Total Pages: 224
Release: 2015-01-08
Genre: Medical
ISBN: 0124051987

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The Management of Scientific Integrity within Academic Medical Centers discusses the impact scientific misconduct has in eight complex case studies. Authors look at multifaceted mixtures of improper behavior, poor communication, cultural issues, adverse medical/health issues, interpersonal problems and misunderstandings to illustrate the challenge of identifying and managing what went wrong and how current policies have led to the establishment of quasi legal processes within academic institutions. The book reviews the current global regulations and concludes with a section authored by a US federal court judge who provides his perspective on the adequacy of current regulations and policies. Shows how complex most scientific integrity cases are, and how little is clear cut in the adjunction of each Discusses how timely and important scientific misconduct is, and its impact on science at large Reviews the current regulations and policies that guide how we manage scientific integrity Examines this complexity in 8 anonymous case studies Concludes with a section authored by an expertly qualified federal court judge

Research in the Biomedical Sciences

Research in the Biomedical Sciences
Author: Michael Williams,Michael Curtis,Kevin Mullane
Publsiher: Academic Press
Total Pages: 382
Release: 2017-10-20
Genre: Science
ISBN: 9780128047262

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Research in the Biomedical Sciences: Transparent and Reproducible documents the widespread concerns related to reproducibility in biomedical research and provides a best practices guide to effective and transparent hypothesis generation, experimental design, reagent standardization (including validation and authentication), statistical analysis, and data reporting. The book addresses issues in the perceived value of the existing peer review process and calls for the need for improved transparency in data reporting. It reflects new guidelines for publication that include manuscript checklists, replication/reproducibility initiatives, and the potential consequences for the biomedical research community and societal health and well-being if training, mentoring, and funding of new generations of researchers and incentives for publications are not improved. This book offers real world examples, insights, and solutions to provide a thought-provoking and timely resource for all those learning about, or engaged in, performing and supervising research across the biomedical sciences. Provides a “big picture perspective on the scope of reproducibility issues and covers initiatives that have potential as effective solutions Offers real-world research context for transparent, reproducible experimental design, execution and reporting of biomedical research with the potential to address aspects of the translational gap in drug discovery Highlights the importance of reproducibility and the necessary changes in biomedical and pharmaceutical research training and incentives to ensure sustainability

Scientific Integrity

Scientific Integrity
Author: Francis L. Macrina
Publsiher: John Wiley & Sons
Total Pages: 440
Release: 2014-07-01
Genre: Science
ISBN: 9781683673514

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This widely adopted textbook provides the essential content and skill-building tools for teaching the responsible conduct of scientific research. Scientific Integrity covers the breadth of concerns faced by scientists: protection of animal and human experimental subjects, scientific publication, intellectual property, conflict of interest, collaboration, record keeping, mentoring, and the social and ethical responsibilities of scientists. Learning activities and resources designed to elucidate the principles of Scientific Integrity include Dozens of highly relevant, interactive case studies for discussion in class or online Numerous print and online resources covering the newest research guidelines, regulations, mandates and policies Discussion questions, role-playing exercises, and survey tools to promote critical thought Documents including published rules of conduct, sample experimentation protocols, and patent applications The new edition of Scientific Integrity responds to significant recent changes—new mandates, policies, laws, and other developments—in the field of responsible conduct of research. Dr. Macrina plants the seeds of awareness of existing, changing, and emerging standards in scientific conduct and provides the tools to promote critical thinking in the use of that information. Scientific Integrity is the original turnkey text to guide the next generations of scientists as well as practicing researchers in the essential skills and approaches for the responsible conduct of science.

Integrity in Scientific Research

Integrity in Scientific Research
Author: National Research Council,Institute of Medicine,Division on Earth and Life Studies,Board on Health Sciences Policy,Committee on Assessing Integrity in Research Environments
Publsiher: National Academies Press
Total Pages: 216
Release: 2002-11-02
Genre: Science
ISBN: 9780309084796

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"Many people say that it is the intellect which makes a great scientist. They are wrong: it is character." -- Albert Einstein Integrity in Scientific Research attempts to define and describe those elements that encourage individuals involved with scientific research to act with integrity. Recognizing the inconsistency of human behavior, it stresses the important role that research institutions play in providing an integrity--rich environment, citing the need for institutions to provide staff with training and education, policies and procedures, and tools and support systems. It identifies practices that characterize integrity in such areas as peer review and research on human subjects and weighs the strengths and limitations of self--evaluation efforts by these institutions. In addition, it details an approach to promoting integrity during the education of researchers, including how to develop an effective curriculum. Providing a framework for research and educational institutions, this important book will be essential for anyone concerned about ethics in the scientific community.

Departments of Labor Health and Human Services Education and Related Agencies Appropriations for 2002

Departments of Labor  Health and Human Services  Education  and Related Agencies Appropriations for 2002
Author: United States. Congress. House. Committee on Appropriations. Subcommittee on the Departments of Labor, Health and Human Services, Education, and Related Agencies
Publsiher: Unknown
Total Pages: 135
Release: 2001
Genre: United States
ISBN: STANFORD:36105050221741

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Public Health Reports

Public Health Reports
Author: Anonim
Publsiher: Unknown
Total Pages: 135
Release: 1990
Genre: Public health
ISBN: UOM:39015018789183

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Fostering Integrity in Research

Fostering Integrity in Research
Author: National Academies of Sciences, Engineering, and Medicine,Policy and Global Affairs,Committee on Science, Engineering, Medicine, and Public Policy,Committee on Responsible Science
Publsiher: National Academies Press
Total Pages: 326
Release: 2018-01-13
Genre: Science
ISBN: 9780309391252

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The integrity of knowledge that emerges from research is based on individual and collective adherence to core values of objectivity, honesty, openness, fairness, accountability, and stewardship. Integrity in science means that the organizations in which research is conducted encourage those involved to exemplify these values in every step of the research process. Understanding the dynamics that support â€" or distort â€" practices that uphold the integrity of research by all participants ensures that the research enterprise advances knowledge. The 1992 report Responsible Science: Ensuring the Integrity of the Research Process evaluated issues related to scientific responsibility and the conduct of research. It provided a valuable service in describing and analyzing a very complicated set of issues, and has served as a crucial basis for thinking about research integrity for more than two decades. However, as experience has accumulated with various forms of research misconduct, detrimental research practices, and other forms of misconduct, as subsequent empirical research has revealed more about the nature of scientific misconduct, and because technological and social changes have altered the environment in which science is conducted, it is clear that the framework established more than two decades ago needs to be updated. Responsible Science served as a valuable benchmark to set the context for this most recent analysis and to help guide the committee's thought process. Fostering Integrity in Research identifies best practices in research and recommends practical options for discouraging and addressing research misconduct and detrimental research practices.

Health Services Reports

Health Services Reports
Author: Anonim
Publsiher: Unknown
Total Pages: 135
Release: 1990
Genre: Audio-visual materials
ISBN: UIUC:30112023557173

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The Ethical Dimensions of the Biological and Health Sciences

The Ethical Dimensions of the Biological and Health Sciences
Author: Ruth Ellen Bulger,Elizabeth Heitman,Stanley Joel Reiser
Publsiher: Cambridge University Press
Total Pages: 386
Release: 2002-07-11
Genre: Medical
ISBN: 0521810531

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This is the second edition of a highly successful and well-received textbook on the responsible conduct of biomedical and health science research. It is aimed at faculty and graduate students in health science and biomedical science programs. In addition, those on National Institute of Health research grants, administrators at universities, and academic health centers will find it a useful resource. The major changes include new chapters providing overviews of each topic, several new published articles added to the readings, revised case studies as well as further readings and web addresses.

Cumulated Index Medicus

Cumulated Index Medicus
Author: Anonim
Publsiher: Unknown
Total Pages: 135
Release: 1991
Genre: Medicine
ISBN: UIUC:30112023522938

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Personalized Nutrition

Personalized Nutrition
Author: Artemis P. Simopoulos,John A. Milner
Publsiher: Karger Medical and Scientific Publishers
Total Pages: 180
Release: 2010
Genre: Medical
ISBN: 9783805594271

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Awareness of the influence of our genetic variation to dietary response (nutrigenetics) and how nutrients may affect gene expression (nutrigenomics) is prompting a revolution in the field of nutrition. Nutrigenetics/Nutrigenomics provide powerful approaches to unravel the complex relationships among nutritional molecules, genetic variants and the biological system. This publication contains selected papers from the '3rd Congress of the International Society of Nutrigenetics/Nutrigenomics' held in Bethesda, Md., in October 2009. The contributions address frontiers in nutrigenetics, nutrigenomics, epigenetics, transcriptomics as well as non-coding RNAs and posttranslational gene regulations in various diseases and conditions. In addition to scientific studies, the challenges and opportunities facing governments, academia and the industry are included. Everyone interested in the future of personalized medicine and nutrition or agriculture, as well as researchers in academia, government and industry will find this publication of the utmost interest for their work.

Ethical Issues in Neurology

Ethical Issues in Neurology
Author: James L. Bernat
Publsiher: Lippincott Williams & Wilkins
Total Pages: 524
Release: 2008
Genre: Medical
ISBN: 0781790603

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Written by an eminent authority from the American Academy of Neurology's Committee on Ethics, Law, and Humanities, this book is an excellent text for all clinicians interested in ethical decision-making. The book features outstanding presentations on dying and palliative care, physician-assisted suicide and voluntary active euthanasia, medical futility, and the relationship between ethics and the law. New chapters in this edition discuss how clinicians resolve ethical dilemmas in practice and explore ethical issues in neuroscience research. Other highlights include updated material on palliative sedation, advance directives, ICU withdrawal of life-sustaining therapy, gene therapy, the very-low-birth-weight premature infant, the developmentally disabled patient, informed consent, organizational ethics, brain death controversies, and fMRI and PET studies relating to persistent vegetative state.

Industrialization of Drug Discovery

Industrialization of Drug Discovery
Author: Jeffrey S. Handen, Ph.D.
Publsiher: CRC Press
Total Pages: 328
Release: 2005-05-26
Genre: Science
ISBN: 9781420028072

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The drug discovery and development process is getting longer, more expensive, and no better. The industry suffers from the same clinical attrition and safety-related market withdrawal rates today as it did 20 years ago. Industrialization of Drug Discovery: From Target Selection Through Lead Optimization scrutinizes these problems in detail, contrasting the promise of technology and industrialization with the challenges of using the tools available to their best advantage. The book explores early successes, examines the current state of the art, and provides a strategic analysis of the issues currently facing drug discovery. Introducing the historical background and current status of the industry, the book delineates the basic tenets underlying modern drug discovery, how they have evolved, and their use in various approaches and strategies. It examines, in detail, the regulations, requirements, guidelines, and draft documents that guide so many FDA actions. The editor devotes the remainder of the discussion to industrialization, compound and knowledge management functions, the drug screening process, collaboration, and finally, ethical issues. Drawing on real-life, from-the-trenches examples, the book elucidates a new approach to drug discovery and development. This modern-day, back-to-basics approach includes three steps: understand the science, unravel the story, and then intelligently apply the technology, bringing to bear the entire armamentarium of industrialization techniques, not just automation, to the discovery process. Using these steps, you can meet the goals of more specific targets, more selective compounds, and decreased cycle times. In effect, you can look for a bigger needle in a smaller haystack. Daniel E. Levy, editor of the Drug Discovery Series, is the founder of DEL BioPharma, a consulting service for drug discovery programs. He also maintains a blog that explores organic chemistry.

Cancer Symptom Science

Cancer Symptom Science
Author: Charles S. Cleeland,Michael J. Fisch,Adrian J. Dunn
Publsiher: Cambridge University Press
Total Pages: 135
Release: 2010-11-18
Genre: Medical
ISBN: 9781139493406

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Cancer Symptom Science is the first interdisciplinary compilation of research on the mechanisms underlying the expression of cancer-related symptoms. It presents innovations in clinical, animal and in vitro research, research methods in brain imaging, and statistical-descriptive approaches to understanding the mechanistic basis of symptom expression. This volume also provides perspectives from patients, government and industry. By collecting and synthesizing the developing threads of new approaches to understanding cancer-related symptoms, the book promotes a pioneering framework for merging behavioral and biological disciplines to clarify mechanisms of symptom evolution, incorporating new technologies, testing novel agents for symptom control, and improving patient functioning and quality of life both during and after cancer treatment. With an expert editorial team led by Charles S. Cleeland, an internationally-recognized leader in cancer pain assessment and treatment, this is essential reading for surgical, clinical and medical oncologists, academic researchers, and pharmaceutical companies developing new agents to control symptom expression.