The Science of Hormesis in Health and Longevity

The Science of Hormesis in Health and Longevity
Author: Suresh I. S. Rattan,Marios Kyriazi
Publsiher: Academic Press
Total Pages: 326
Release: 2018-10-23
Genre: Medical
ISBN: 9780128142547

Download The Science of Hormesis in Health and Longevity Book in PDF, Epub and Kindle

The Science of Hormesis in Health and Longevity provides a comprehensive review of mild stress-induced physiological hormesis and its role in the maintenance and promotion of health. Coverage includes the underlying mechanisms of hormesis, including details of stress-response signaling, an enriched environment, positive challenges and dose-response mechanisms, amongst others. Research from top experts is presented to provide suggestions for developing novel therapeutic strategies, along with lifestyle interventions to promote health and homoeostasis. Researchers in aging and physiology, gerontologists, clinicians and medical students will find this a valuable addition for their work. Provides a comprehensive, scholarly review of the current state of hormesis in physiology, health, disease and aging Includes multiple perspectives and in-depth analysis by top experts involved in cutting-edge research to provide developing, novel therapeutic strategies, as well as lifestyle interventions Offers a clear understanding of hormesis’ underlying mechanisms, including details of stress-response signaling, an enriched environment, positive challenges, dose-response mechanisms, and more

Explaining Health Across the Sciences

Explaining Health Across the Sciences
Author: Jonathan Sholl,Suresh I.S. Rattan
Publsiher: Springer Nature
Total Pages: 555
Release: 2020-08-28
Genre: Medical
ISBN: 9783030526634

Download Explaining Health Across the Sciences Book in PDF, Epub and Kindle

This edited volume aims to better understand the multifaceted phenomenon we call health. Going beyond simple views of health as the absence of disease or as complete well-being, this book unites scientists and philosophers. The contributions clarify the links between health and adaptation, robustness, resilience, or dynamic homeostasis, and discuss how to achieve health and healthy aging through practices such as hormesis. The book is divided into three parts and a conclusion: the first part explains health from within specific disciplines, the second part explores health from the perspective of a bodily part, system, function, or even the environment in which organisms live, and the final part looks at more clinical or practical perspectives. It thereby gathers, across 30 chapters, diverse perspectives from the broad fields of evolutionary and systems biology, immunology, and biogerontology, more specific areas such as odontology, cardiology, neurology, and public health, as well as philosophical reflections on mental health, sexuality, authenticity and medical theories. The overarching aim is to inform, inspire and encourage intellectuals from various disciplines to assess whether explanations in these disparate fields and across biological levels can be sufficiently systematized and unified to clarify the complexity of health. It will be particularly useful for medical graduates, philosophy graduates and research professionals in the life sciences and general medicine, as well as for upper-level graduate philosophy of science students.

Human Aging

Human Aging
Author: Calogero Caruso,Giuseppina Candore
Publsiher: Academic Press
Total Pages: 382
Release: 2021-05-11
Genre: Science
ISBN: 9780128227374

Download Human Aging Book in PDF, Epub and Kindle

Human Aging: From Cellular Mechanisms to Therapeutic Strategies offers an exhaustive picture of all the biological aspects of human aging by describing the key mechanisms associated with human aging and covering events that could disrupt the normal course of aging. Each chapter includes a summary of the salient points covered, along with futures prospects. The book provides readers with the information they need to gain or deepen the skills needed to evaluate the mechanisms of aging and age-related diseases and to monitor the effectiveness of therapies aimed at slowing aging. The book encourages PhD and Postdoc students, researchers, health professionals and others interested in the biology of aging to explore the fascinating and challenging questions about why and how we age as well as what can and cannot be done about it. Concentrates on different processes, e.g., oxidative stress, cellular senescence and Inflammaging Offers the ability to access cross-sectional knowledge more easily Written by expert researchers in biogerontology who are actively involved in various fields within aging research

Mild Stress and Healthy Aging

Mild Stress and Healthy Aging
Author: Eric Le Bourg,Suresh I.S. Rattan
Publsiher: Springer Science & Business Media
Total Pages: 188
Release: 2008-01-24
Genre: Medical
ISBN: 9781402068690

Download Mild Stress and Healthy Aging Book in PDF, Epub and Kindle

Whereas chronic stress has well known harmful effects, recent research shows that intermittent exposure of cells and organisms to mild stress can improve various biological parameters. This book brings together some of the world leaders in this area of research who present a critical analysis of the ongoing research with respect to the effects and mechanisms of action of various types of mild stress. Novel approaches to improving health and longevity are introduced.

Lifespan

Lifespan
Author: David A. Sinclair,Matthew D. LaPlante
Publsiher: Atria Books
Total Pages: 432
Release: 2019-09-10
Genre: Science
ISBN: 9781501191978

Download Lifespan Book in PDF, Epub and Kindle

A NEW YORK TIMES BESTSELLER “Brilliant and enthralling.”​ —The Wall Street Journal A paradigm-shifting book from an acclaimed Harvard Medical School scientist and one of Time’s most influential people. It’s a seemingly undeniable truth that aging is inevitable. But what if everything we’ve been taught to believe about aging is wrong? What if we could choose our lifespan? In this groundbreaking book, Dr. David Sinclair, leading world authority on genetics and longevity, reveals a bold new theory for why we age. As he writes: “Aging is a disease, and that disease is treatable.” This eye-opening and provocative work takes us to the frontlines of research that is pushing the boundaries on our perceived scientific limitations, revealing incredible breakthroughs—many from Dr. David Sinclair’s own lab at Harvard—that demonstrate how we can slow down, or even reverse, aging. The key is activating newly discovered vitality genes, the descendants of an ancient genetic survival circuit that is both the cause of aging and the key to reversing it. Recent experiments in genetic reprogramming suggest that in the near future we may not just be able to feel younger, but actually become younger. Through a page-turning narrative, Dr. Sinclair invites you into the process of scientific discovery and reveals the emerging technologies and simple lifestyle changes—such as intermittent fasting, cold exposure, exercising with the right intensity, and eating less meat—that have been shown to help us live younger and healthier for longer. At once a roadmap for taking charge of our own health destiny and a bold new vision for the future of humankind, Lifespan will forever change the way we think about why we age and what we can do about it.

The Longevity Code

The Longevity Code
Author: Kris Verburgh
Publsiher: The Experiment
Total Pages: 320
Release: 2019-12-24
Genre: Health & Fitness
ISBN: 9781615194971

Download The Longevity Code Book in PDF, Epub and Kindle

Slow down the aging process and live well for longer Do you know exactly how and why you age? And what you can do— whatever your current age—to slow that process and have a longer, healthier life? In The Longevity Code, medical doctor Kris Verburgh illuminates the biological mechanisms that make our bodies susceptible to heart attacks, dementia, diabetes, and other aging-related diseases. With the facts laid out, he provides the tools we need to slow down the aging process. His scientifically backed Longevity Staircase outlines a simple yet innovative step-by-step method offering better health and a longer life span– especially the crucial role of proper nutrition and exercise. But diet and exercise might not be the only way to crack the “longevity code”: With each passing day, advances in biotechnology that were once the stuff of science fiction are emerging. Dr. Verburgh discusses how new types of vaccines, mitochondrial DNA, CRISPR proteins, and stem cells may help us slow and even reverse aging—now and in the future—and when paired with the right lifestyle, lead to longer, healthier lives than we’ve ever imagined.

Cracking the Aging Code

Cracking the Aging Code
Author: Josh Mitteldorf,Dorion Sagan
Publsiher: Flatiron Books
Total Pages: 320
Release: 2016-06-14
Genre: Science
ISBN: 9781250061720

Download Cracking the Aging Code Book in PDF, Epub and Kindle

A revolutionary examination of why we age, what it means for our health, and how we just might be able to fight it. In Cracking the Aging Code, theoretical biologist Josh Mitteldorf and award-winning writer and ecological philosopher Dorion Sagan reveal that evolution and aging are even more complex and breathtaking than we originally thought. Using meticulous multidisciplinary science, as well as reviewing the history of our understanding about evolution, this book makes the case that aging is not something that “just happens,” nor is it the result of wear and tear or a genetic inevitability. Rather, aging has a fascinating evolutionary purpose: to stabilize populations and ecosystems, which are ever-threatened by cyclic swings that can lead to extinction. When a population grows too fast it can put itself at risk of a wholesale wipeout. Aging has evolved to help us adjust our growth in a sustainable fashion as well as prevent an ecological crisis from starvation, predation, pollution, or infection. This dynamic new understanding of aging is provocative, entertaining, and pioneering, and will challenge the way we understand aging, death, and just what makes us human.

Nutrition Food and Diet in Ageing and Longevity

Nutrition  Food and Diet in Ageing and Longevity
Author: Suresh I. S. Rattan,Gurcharan Kaur
Publsiher: Springer Nature
Total Pages: 642
Release: 2021-11-04
Genre: Family & Relationships
ISBN: 9783030830175

Download Nutrition Food and Diet in Ageing and Longevity Book in PDF, Epub and Kindle

This edited volume is a compilation of 30 articles discussing what constitutes food for health and longevity. The aim is to provide up-to-date information, insights, and future tendencies in the ongoing scientific research about nutritional components, food habits and dietary patterns in different cultures. The health-sustaining and health-promoting effects of food are certainly founded in its overall composition of macronutrients and micronutrients. However, the consumption of these nutrients is normally in the form of raw or prepared food from the animal and plant sources. The book is divided into four parts and a conclusion, and successfully convenes the well-established information and knowledge, along with the personal views of a diversified group of researchers and academicians on the multifaceted aspects of nutrition, food and diet. The first part reviews the scientific information about proteins, carbohydrates, fats and oils, micronutrients, pro- and pre-biotics, and hormetins, along with a discussion of the evolutionary principles and constraints about what is optimal food, if any. The second part discusses various kinds of foods and food supplements with respect to their claimed benefits for general health and prevention of some diseases. The third part brings in the cultural aspects, such as what are the principles of healthy eating according to the traditional Chinese and Indian systems, what is the importance of mealing times and daily rhythms, and how different cultures have developed different folk wisdoms for eating for health, longevity and immortality. In the part four, various approaches which are either already in practice or are still in the testing and research phases are discussed and evaluated critically, for example intermittent fasting and calorie restriction, food-based short peptides, senolytics, Ayurvedic compounds, optimal food for old people, and food for the prevention of obesity and other metabolic disorders. The overreaching aim of this book is to inform, inspire and encourage students, researchers, educators and medical health professionals thinking about food and food habits in a holistic context of our habits, cultures and patterns. Food cannot be reduced to a pill of nutritional components. Eating food is a complex human behavior culturally evolved over thousands of years. Perhaps the old adage “we are what we eat” needs to be modified to “we eat what we are”.

Successful Aging

Successful Aging
Author: Clemens Tesch-Romer,Hans-Werner Wahl,Suresh Rattan,Liat Ayalon
Publsiher: Oxford University Press
Total Pages: 128
Release: 2021-10-29
Genre: Medical
ISBN: 9780192651969

Download Successful Aging Book in PDF, Epub and Kindle

The ambition of ageing science to discover the golden fleece of longevity and health is closely connected to the concept of 'successful ageing'. Still, for a large portion of the population, frailty and cognitive impairment is the reality of ageing, and it is by no means certain if health promotion, prevention and other interventions will reduce the probability of its occurrence. This book argues that a narrow understanding of 'successful ageing' as good health, full functioning, and active participation in society excludes a large portion of ageing individuals from the quest for a good life in old age. The challenge is that the term 'successful ageing' comes with ambitions but also with ambivalence. On the one hand, it counteracts the deficit view of ageing and facilitates visionary thinking on what might be possible in the future. On the other hand, its implicitly ageist and derogative features have negative consequences to older people and society at large. So, what is successful ageing? We provide answers at three levels: First, we synthesise the various models used to define successful ageing into a heuristic scheme able to unravel the normative complexity and differences inherent in existing models. Second, we anchor successful ageing models in a tripartite way at micro (individual), meso, and macro analytic levels of human development. Third, we argue that the usefulness of successful ageing in guiding policy will only profit from the concept, if it follows a pluralistic and holistic view without hastily deciding for one model only.

Hormesis

Hormesis
Author: Mark P. Mattson,Edward J. Calabrese
Publsiher: Springer Science & Business Media
Total Pages: 213
Release: 2009-12-01
Genre: Medical
ISBN: 1607614952

Download Hormesis Book in PDF, Epub and Kindle

Hormesis is a poorly understood phenomenon affecting all forms of life on earth. This groundbreaking book summarizes and analyzes the various positives of hormesis in an attempt to reveal hormesis as a fundamental principle of biomedical sciences as a whole.

Inflammation Advancing Age and Nutrition

Inflammation  Advancing Age and Nutrition
Author: Irfan Rahman,Debasis Bagchi
Publsiher: Academic Press
Total Pages: 394
Release: 2013-09-03
Genre: Technology & Engineering
ISBN: 9780123978073

Download Inflammation Advancing Age and Nutrition Book in PDF, Epub and Kindle

The book provides a comprehensive overview to understanding the integrated impact of the concepts of cellular and molecular aspects, models, environmental factors, and lifestyle involved in premature aging. Additionally, it examines how functional food, dietary nutraceuticals or pharmacological compounds can reverse inflammation and premature aging based on personalized medicine. This book is a valuable resource for health professionals, scientists and researchers, nutritionists, health practitioners, students and for all those who wish to broaden their knowledge in the allied field. Includes models of aging, including worm, mouse and human Explores the relationship of inflammation with diseases, including ocular health, Alzheimer's and Parkinson's disease, and muscle health Encompasses a variety of lifestyle impacts, including diet, exercise and nutrition Includes suggested nutritional interventions

Spring Chicken

Spring Chicken
Author: Bill Gifford
Publsiher: Grand Central Publishing
Total Pages: 368
Release: 2015-02-17
Genre: Self-Help
ISBN: 9781455527458

Download Spring Chicken Book in PDF, Epub and Kindle

From acclaimed journalist Bill Gifford comes a roaring journey into the world of anti-aging science in search of answers to a universal obsession: what can be done about getting old? SPRING CHICKEN: Stay Young Forever (or Die Trying) SPRING CHICKEN is a full-throttle, high-energy ride through the latest research, popular mythology, and ancient wisdom on mankind's oldest obsession: How can we live longer? And better? In his funny, self-deprecating voice, veteran reporter Bill Gifford takes readers on a fascinating journey through the science of aging, from the obvious signs like wrinkles and baldness right down into the innermost workings of cells. We visit cutting-edge labs where scientists are working to "hack" the aging process, like purging "senescent" cells from mice to reverse the effects of aging. He'll reveal why some people live past 100 without even trying, what has happened with resveratrol, the "red wine pill" that made headlines a few years ago, how your fat tissue is trying to kill you, and how it's possible to unlock longevity-promoting pathways that are programmed into our very genes. Gifford separates the wheat from the chaff as he exposes hoaxes and scams foisted upon an aging society, and arms readers with the best possible advice on what to do, what not to do, and what life-changing treatments may be right around the corner. An intoxicating mixture of deep reporting, fascinating science, and prescriptive takeaway, SPRING CHICKEN will reveal the extraordinary breakthroughs that may yet bring us eternal youth, while exposing dangerous deceptions that prey on the innocent and ignorant.

Hormesis in Health and Disease

Hormesis in Health and Disease
Author: Suresh I. S. Rattan,Éric Le Bourg
Publsiher: CRC Press
Total Pages: 382
Release: 2014-05-16
Genre: Medical
ISBN: 9781482205466

Download Hormesis in Health and Disease Book in PDF, Epub and Kindle

Some mild stresses have positive effects on survival and aging as shown in animal models. There is also a large body of research that demonstrates these hormetic effects on aging, health, and resistance to severe stresses and diseases in human beings. However, the data are dispersed in the literature and are not always interpreted as hormetic effects. Hormesis in Health and Disease reviews the evidence for hormesis in humans as achieved through a variety of stresses or stimuli, and discusses mechanisms of hormesis and its ethical and legal issues. Divided into four sections, this book presents the current state of research, including questions, debates, doubts, and controversies in hormesis. Section I covers the history and terminology of hormesis, describing its main features and providing necessary background information. Section II shows that hormetic effects can be caused by various stresses—including physical exercise, nutritional components, fasting, micronutrients, irradiation, heat, ischemia, and mental challenge—and can be observed both in organs and at the organism level. Section III reviews possible mechanisms of hormesis that have been elucidated at this point. Section IV discusses the wider consequences hormesis may have for everyone. This book demonstrates that health beneficial hormetic effects do exist in human beings. It offers information to inspire key players to initiate new strategies to elucidate the strengths and limits of the dual nature of stress.

Encyclopedia of Biomedical Gerontology

Encyclopedia of Biomedical Gerontology
Author: Anonim
Publsiher: Academic Press
Total Pages: 1640
Release: 2019-11-20
Genre: Medical
ISBN: 9780128160763

Download Encyclopedia of Biomedical Gerontology Book in PDF, Epub and Kindle

Encyclopedia of Biomedical Gerontology presents a wide range of topics, ranging from what happens in the body during aging, the reasons and mechanisms relating to those age-related changes, and their clinical, psychological and social modulators and determinants. The book covers the biological and medical aspects of gerontology within the general framework of the biological basis of assessing age, biological mechanisms of aging, age-related changes in biological systems, human age-related diseases, the biomedical practicality and impracticality of interventions, and finally, the ethics of intervention. Provides a ‘one-stop’ resource to information written by world-leading scholars in the field of biomedical gerontology Fills a critical gap of information in a field that has seen significant progress in the last 10 years

Age Later

Age Later
Author: Nir Barzilai, M.D.
Publsiher: St. Martin's Press
Total Pages: 320
Release: 2020-06-16
Genre: Health & Fitness
ISBN: 9781250230867

Download Age Later Book in PDF, Epub and Kindle

How do some people avoid the slowing down, deteriorating, and weakening that plagues many of their peers decades earlier? Are they just lucky? Or do they know something the rest of us don’t? Is it possible to grow older without getting sicker? What if you could look and feel fifty through your eighties and nineties? Founder of the Institute for Aging Research at the Albert Einstein College of Medicine and one of the leading pioneers of longevity research, Dr. Nir Barzilai’s life’s work is tackling the challenges of aging to delay and prevent the onset of all age-related diseases including “the big four”: diabetes, cancer, heart disease, and Alzheimer’s. One of Dr. Barzilai’s most fascinating studies features volunteers that include 750 SuperAgers—individuals who maintain active lives well into their nineties and even beyond—and, more importantly, who reached that ripe old age never having experienced cardiovascular disease, cancer, diabetes, or cognitive decline. In Age Later, Dr. Barzilai reveals the secrets his team has unlocked about SuperAgers and the scientific discoveries that show we can mimic some of their natural resistance to the aging process. This eye-opening and inspirational book will help you think of aging not as a certainty, but as a phenomenon—like many other diseases and misfortunes—that can be targeted, improved, and even cured.