Toxicological Evaluation of Electronic Nicotine Delivery Products

Toxicological Evaluation of Electronic Nicotine Delivery Products
Author: Manuel Peitsch,Julia Hoeng
Publsiher: Academic Press
Total Pages: 620
Release: 2021-01-14
Genre: Medical
ISBN: 9780128209356

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Toxicological Evaluation of Electronic Nicotine Delivery Products (ENDP) discusses the scientific basis for the toxicological assessment and evaluation of ENDPs. The book covers aerosol chemistry, in vitro and in vivo studies as well as clinical studies. It provides the basis for the evaluation of short and long term-effects, along with relative risks. It also examines the potential role of ENDPs in tobacco harm reduction and how they may reduce the risk of disease in smokers who switch to them. This book is a comprehensive resource for toxicologists, health practitioners and public health professionals who want the scientific information necessary to assess the relative risk of ENDPs when compared with cigarette smoking and cessation. Delivers a comprehensive overview of current state of science Offers an integrated analysis of e-cigarettes and heated tobacco products Provides guidance for methodologies

Public Health Consequences of E Cigarettes

Public Health Consequences of E Cigarettes
Author: National Academies of Sciences, Engineering, and Medicine,Health and Medicine Division,Board on Population Health and Public Health Practice,Committee on the Review of the Health Effects of Electronic Nicotine Delivery Systems
Publsiher: National Academies Press
Total Pages: 774
Release: 2018-05-18
Genre: Medical
ISBN: 9780309468374

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Millions of Americans use e-cigarettes. Despite their popularity, little is known about their health effects. Some suggest that e-cigarettes likely confer lower risk compared to combustible tobacco cigarettes, because they do not expose users to toxicants produced through combustion. Proponents of e-cigarette use also tout the potential benefits of e-cigarettes as devices that could help combustible tobacco cigarette smokers to quit and thereby reduce tobacco-related health risks. Others are concerned about the exposure to potentially toxic substances contained in e-cigarette emissions, especially in individuals who have never used tobacco products such as youth and young adults. Given their relatively recent introduction, there has been little time for a scientific body of evidence to develop on the health effects of e-cigarettes. Public Health Consequences of E-Cigarettes reviews and critically assesses the state of the emerging evidence about e-cigarettes and health. This report makes recommendations for the improvement of this research and highlights gaps that are a priority for future research.

Comparative Risk Assessment of Electronic Nicotine Delivery Systems e cigarettes and Conventional Cigarettes

Comparative Risk Assessment of Electronic Nicotine Delivery Systems   e cigarettes   and Conventional Cigarettes
Author: Jinsong Chen
Publsiher: Unknown
Total Pages: 246
Release: 2016
Genre: Electronic Book
ISBN: OCLC:953389495

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Introduction: The use of electronic cigarettes (ECs) is controversial. Among the issues of concern is safety: some people think ECs are safer alternatives to conventional cigarettes (CCs), while others are concerned about the possible health effects of using ECs. Although many studies have identified hazards in EC emissions, there is only limited information about exposure levels and the likely health risks of using ECs. Methods: This study aimed to characterise the health risks of using ECs and compare them with the risks of using CCs by utilizing the U.S. EPA health risk assessment model. Hazards were identified and profiled (toxicological and exposure) using document review. The risk from exposure to hazards was thus identified and the overall health risks of using ECs and CCs were compared, and then benchmarked with international guideline levels for each hazard to evaluate whether the detected hazards might pose a significant health risk to users or not, given comparable exposures. Results: Exposures to toxicants of concern identified in EC emissions (acetaldehyde, acrolein, formaldehyde, diethylene glycol, propylene glycol, cadmium, nickel, NNK, and NNN) are almost all far lower than in CC emissions, indicating EC use under standard use conditions is likely to be far safer than smoking. As most hazards’ exposure levels in EC emissions are lower than the defined guideline levels, ECs are also likely to be of low risk to health. Conclusions & Recommendations: The health risks of using ECs are lower than CCs. In a few studies of some ECs, some toxicant levels exceeded levels regarded as safe by international standards. However, studies of ECs lack standardisation in the assessment methods for EC product performance, usage patterns and exposure. Future studies should adhere to a standard methodology to enable ready comparisons. Regulation of EC manufacture and sales is needed to prevent the sale of low quality ECs. Lastly, health professionals and the general public need more information on ECs as safer alternatives to cigarette smoking.

Reproductive and Developmental Toxicology

Reproductive and Developmental Toxicology
Author: Ramesh C. Gupta
Publsiher: Academic Press
Total Pages: 1556
Release: 2022-03-31
Genre: Medical
ISBN: 9780323915601

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Reproductive and Developmental Toxicology, Third Edition is a comprehensive and authoritative resource, providing the latest literature on this complex subject by focusing on three core components - parent, placenta and fetus - and the continuous changes that occur in each. Enriched with relevant references describing every aspect of reproductive toxicology, this revised and updated resource addresses the totality of the subject, discussing a broad range of topics including nanoparticles and radiation, gases and solvents, smoking, alcohol and drugs of abuse, and metals, among others. In addition, it is the only resource to include reproductive and developmental toxicity in domestic animals, fish and wildlife With a special focus on placental toxicity, this book is the only available reference to connect the three key risk stages. Completely revised and updated to include the most recent developments in the field, this book is an essential resource for advanced students and researchers in toxicology, as well as biologists, pharmacologists and teratologists from academia, industry and regulatory agencies. Provides a complete, up-to-date, integrated source of information on the key risk stages during reproduction and development Offers diverse and unique in vitro and in vivo toxicity models for reproductive and developmental toxicity testing in a user-friendly format that assists in comparative analysis Includes new chapters on developments in systems toxicology and predictive modeling of male developmental toxicity, adverse outcome pathways in reproductive and developmental toxicology, ovarian and endometrial toxicity, developmental neurotoxicity of air pollution, and more

Toxicological Risk Assessment and Multi System Health Impacts from Exposure

Toxicological Risk Assessment and Multi System Health Impacts from Exposure
Author: Aristidis M. Tsatsakis
Publsiher: Elsevier
Total Pages: 684
Release: 2021-08-01
Genre: Medical
ISBN: 9780323853583

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Toxicological Risk Assessment and Multisystem Health Impacts From Exposure highlights the emerging problems of human and environmental health attributable to cumulative and multiple sources of long-term exposure to environmental toxicants. The book describes the cellular, biological, immunological, endocrinologic, genetic, and epigenetic effects of long-term exposure. It examines how the combined exposure to nanomaterials, metals, pharmaceuticals, multifrequency radiation, dietary mycotoxins, and pesticides accelerates ecotoxicity in humans, animals, plants, and the larger environment. The book goes on to also offer insights into mixture risk assessments, protocols for evaluating the risks, and how this information can serve the regulatory agencies in setting safer exposure limits. The book is a go-to resource for scientists and professionals in the field tackling the current and emerging trends in modern toxicology and risk assessment. • Bridges basic research with clinical, epidemiological, regulatory, and translational research, conveying both an introductory understanding and the latest developments in the field • Evaluates real-life human health risk assessment for long-term exposures to xenobiotic mixtures and the role they play in contributing to chronic disease • Discusses advances in predictive (in silico) toxicology tools and the benefits of using omics technologies in toxicology research

The Chemical Components of Tobacco and Tobacco Smoke

The Chemical Components of Tobacco and Tobacco Smoke
Author: Alan Rodgman,Thomas A. Perfetti
Publsiher: CRC Press
Total Pages: 2332
Release: 2016-04-19
Genre: Medical
ISBN: 9781466515529

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Authored by two longtime researchers in tobacco science, The Chemical Components of Tobacco and Tobacco Smoke, Second Edition chronicles the progress made from late 2008 through 2011 by scientists in the field of tobacco science. The book examines the isolation and characterization of each component. It explores developments in pertinent analytical

Electronic Cigarettes and Vape Devices

Electronic Cigarettes and Vape Devices
Author: Susan Chu Walley,Karen Wilson
Publsiher: Springer Nature
Total Pages: 144
Release: 2021-08-12
Genre: Medical
ISBN: 9783030786724

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Electronic cigarettes (E-cigarettes), also known as vape devices or by trade names such as JUUL, are handheld devices that aerosolize liquid commonly containing nicotine, humectants and flavorings. Used by 1 in 5 high school students in 2020, they are the most common tobacco product used by youth. E-cigarette use has been associated with a variety of health issues such as nicotine addiction, e-cigarette or vaping associated lung illness (EVALI), seizures, and increased risk of cardiovascular disease. This first-of-its-kind book begins with an introduction and background on the historical context of tobacco products. The next chapters provide an overview of the e-cigarette landscape and reviews the e-cigarette devices and solutions and the evolution of these products. This is followed by reviews of the health effects of e-cigarettes on users and non-users and includes recommendations for prevention and treatment of youth e-cigarette use. The last few chapters address the public health impact of e-cigarettes with a review of the evidence of e-cigarettes in smoking cessation. The book closes with policy and advocacy approaches and a resource page. E-cigarette and vape device use pose a public health crisis. This book contains succinct practical information and is a key reference for pediatricians as well as clinicians of all specialities. It also serves as a resource for health professionals, including tobacco dependence treatment providers and public health experts.

Cellular In Vitro Testing

Cellular In Vitro Testing
Author: John Haycock,Arti Ahluwalia,J. Malcolm Wilkinson
Publsiher: CRC Press
Total Pages: 192
Release: 2014-08-27
Genre: Medical
ISBN: 9789814364980

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Growing cells in 2D under static conditions has long been the gold standard of cell culture, despite this method not being representative of the complex in vivo environment. The use of animal models also has clear ethical and scientific limitations, and increasingly the 3Rs (replacement, refinement, reduction) in relation to animal models are being integrated into the modern-day scientific practice. Focusing on new 3D in vitro methods now available to researchers, this book brings together examples of leading-edge work being conducted internationally for improving in vitro cell culture methods, in particular the use of systems for enabling cell culture under laminar flow and the use of 3D scaffolds for providing cells with a structure which replicates the function of the extracellular matrix and encouraging interactions more akin to an in vivo environment.

E Cigarette Use Among Youth and Young Adults a Report of the Surgeon General

E Cigarette Use Among Youth and Young Adults  a Report of the Surgeon General
Author: Centers for Disease Control and Prevention,National Center National Center for Chronic Disease Prevention and Health Promotion,U.S. Department of Health and Human Services
Publsiher: Unknown
Total Pages: 293
Release: 2019-07-26
Genre: Electronic Book
ISBN: 1082814911

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Tobacco use among youth and young adults in any form, including e-cigarettes, is not safe. In recent years, e-cigarette use by youth and young adults has increased at an alarming rate. E-cigarettes are now the most commonly used tobacco product among youth in the United States. This timely report highlights the rapidly changing patterns of e-cigarette use among youth and young adults, assesses what we know about the health effects of using these products, and describes strategies that tobacco companies use to recruit our nation's youth and young adults to try and continue using e-cigarettes. The report also outlines interventions that can be adopted to minimize the harm these products cause to our nation's youth.E-cigarettes are tobacco products that deliver nicotine. Nicotine is a highly addictive substance, and many of today's youth who are using e-cigarettes could become tomorrow's cigarette smokers. Nicotine exposure can also harm brain development in ways that may affect the health and mental health of our kids.E-cigarette use among youth and young adults is associated with the use of other tobacco products, including conventional cigarettes. Because most tobacco use is established during adolescence, actions to prevent our nation's young people from the potential of a lifetime of nicotine addiction are critical.E-cigarette companies appear to be using many of the advertising tactics the tobacco industry used to persuade a new generation of young people to use their products. Companies are promoting their products through television and radio advertisements that use celebrities, sexual content, and claims of independence to glamorize these addictive products and make them appealing to young people.

Preventing Tobacco Use Among Youth and Young Adults

Preventing Tobacco Use Among Youth and Young Adults
Author: United States. Public Health Service. Office of the Surgeon General
Publsiher: U.S. Government Printing Office
Total Pages: 928
Release: 2012
Genre: Health & Fitness
ISBN: UCBK:C095488540

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NOTE: NO FURTHER DISCOUNT FOR THIS PRINT PRODUCT -- OVERSTOCK SALE -- Significantly reduced list price This Surgeon General s Report details the causes and the consequences of tobacco use among youth and young adults by focusing on the social, environmental, advertising, and marketing influences that encourage youth and young adults to initiate and sustain tobacco use. This is the first time tobacco data on young adults as a discrete population have been explored in detail. The report also highlights successful strategies to prevent young people from using tobacco. This three volume set includes the following items: A booklet containing highlights from the 2012 Surgeon General s report on tobacco use among youth and teens ages 12 through 17 and young adults ages 18 through 26. This booklet provides an overview of tobacco use within this targeted age group. The second booklet is an Executive Summary with two messages. One message from for Kathleen Sebelius, Secretary of Health and Human Services and a second message from Howard Koh, Assistant Secretary of Health and contains a brief introduction to the set and summary and conclusions for each chapter contained in the final volume. The final volume contains over 800 pages of documentation, interwoven with text and data addressing the adverse health consequences of tobacco use by children and young adults. It includes research on a variety of topics, including nicotine addiction, trends in cigarette smoking among young adults, trends in smokeless tobacco use and cigar smoking over time, genetic factors in tobacco use among youth, and mass media influence on smoking to this age group to name a few. This third volume is rich with table data research findings to support the Surgeon General s concerns with America s use and tobacco. If you would like to find similiar products, please check out our Alcoholism, Smoking, and Substance Abuse resources collection at this link: https: //bookstore.gpo.gov/catalog/health-benefits/alcoholism-smoking-substance-abuse "

Handbook on the Toxicology of Metals

Handbook on the Toxicology of Metals
Author: Gunnar F. Nordberg,Max Costa
Publsiher: Academic Press
Total Pages: 796
Release: 2021-12-10
Genre: Medical
ISBN: 9780128232934

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Handbook on the Toxicology of Metals, Fifth Edition, Volume I: General Considerations is the first volume of a two-volume work that gives an overview and reviews topics of general importance including reviews of various health effects of trace metals. The book emphasizes toxic effects in humans, along with discussions on the toxic effects of animals and biological systems in vitro when relevant. The book has been systematically updated with the latest studies and advances in technology and contains several new chapters. As a multidisciplinary resource that integrates both human and environmental toxicology, the book is a comprehensive and valuable reference for toxicologists, physicians, pharmacologists, and environmental scientists in the fields of environmental, occupational and public health. Contains peer-reviewed chapters that deal with the effects of metallic elements and their compounds on biological systems Includes information on sources, transport and the transformation of metals in the environment Covers the ecological effects of metals to provide a basis for better understanding of the potential for adverse effects on human health Provides critical information on the properties, use, biological monitoring, dose-response relationships, diagnosis, treatment and prevention of metallic elements and compounds

Characteristics and Composition of Aerosol Generated by Electronic Cigarettes What is the Impact on Human Health

Characteristics and Composition of Aerosol Generated by Electronic Cigarettes  What is the Impact on Human Health
Author: Dominic L. Palazzolo
Publsiher: Frontiers Media SA
Total Pages: 135
Release: 2021-09-29
Genre: Science
ISBN: 9782889713882

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WHO Study Group on Tobacco Product Regulation Report on the scientific basis of tobacco product regulation

WHO Study Group on Tobacco Product Regulation  Report on the scientific basis of tobacco product regulation
Author: Anonim
Publsiher: World Health Organization
Total Pages: 135
Release: 2021-05-04
Genre: Law
ISBN: 9789240022720

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This eighth report of the Study Group addresses electronic nicotine delivery system (ENDS), electronic non-nicotine delivery system (ENNDS) and heated tobacco product (HTPs); however, it does not cover all aspects of these products, because many of the papers were written to meet the request of COP8, which was to review understanding on novel and emerging tobacco products (FCTC/COP8). Continued research is necessary on these products; the Study Group will cover other products of interest (including traditional products, such as waterpipes, cigarettes and smokeless tobacco) in its next report, guided by countries’ regulatory requirements and pertinent issues in tobacco product regulation. This will ensure continued, timely technical support to all countries and address all products, recognizing that their availability depends on the jurisdiction.

Case Studies in Medical Toxicology

Case Studies in Medical Toxicology
Author: Leslie R. Dye,Christine Murphy,Diane P. Calello,Michael D. Levine,Aaron Skolnik
Publsiher: Springer
Total Pages: 256
Release: 2017-12-22
Genre: Medical
ISBN: 9783319564494

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The ACMT National Case Conference (NCC) is a monthly discussion of novel or interesting cases in medical toxicology. Participation is through online webinar, and the conferences are recorded to allow for review at any time. The cases in this book are taken from recordings of NCC with edits and revisions by contributors and editors to demonstrate educational points. The majority of the case information is from the original recording and represents actual patient presentations. However, some of the details have been changed and fictional information added to enhance the educational value. This volume covers a broad range of toxicological topics, and specialty guidance is offered at the end of every case to aid non-toxicologists. The dilemmas are applicable to both academic and clinical medicine. A list of relevant questions is also provided for each case. Subjects include common toxicological problems, rare presentations of common problems, common problems with controversial treatments or difficult diagnoses, and rare problems. Case Studies in Medical Toxicology from the American College of Medical Toxicology is a detailed reference text on specific toxicological issues and also serves as a practical review for those taking board exams. As a result, this volume is an important and necessary resource for medical students, residents, and fellows, as well as primary-care physicians, intensivists, and toxicologistsCase Studies in Medical Toxicology from the American College of Medical Toxicology is a detailed reference text on specific toxicological issues and also serves as a practical review for those taking board exams. As a result, this volume is an important and necessary resource for medical students, residents, and fellows, as well as primary-care physicians, intensivists, and toxicologists. All proceeds from this book will be donated to the Medical Toxicology Foundation.

The Behavioral Aspects of Smoking

The Behavioral Aspects of Smoking
Author: Norman A. Krasnegor
Publsiher: Unknown
Total Pages: 192
Release: 1979
Genre: Cigarette habit
ISBN: UCR:31210023566753

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